Magnetic Resonance Spectroscopy in Bipolar Disorder

Vecera, Courtney M.; Chong, Audrey C.; Ruiz, Ana; Rong, Carola; Jones, Gregory; Machado‐Vieira, Rodrigo; Soares, Jair C.

doi:10.1016/b978-0-12-821398-8.00030-8

Cited by 4 publications

(3 citation statements)

References 79 publications

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“…Despite the promising results of the study, as we focused on According to a suggestive origin of injury in patients with COVID-19-related anosmia, pharmacologic, or nonpharmacologic therapies to increase NAA levels using electroconvulsive therapy, cognitive behavioral therapy, and physical exercise or short-course pharmacological therapies with lithium, valproate, or antipsychotics could be tried in these patients as they can lead to a widespread increase in brain NAA levels. 24,25 CONCLUSIONS MRS is an exciting and novel approach for evaluating prolonged olfactory dysfunction after COVID-19-related anosmia. However, it is still not entirely clear that abnormalities in the CNS are the cause or the effect of olfactory loss due to COVID-19 infection.…”

Section: Discussionmentioning

confidence: 99%

“…According to a suggestive origin of injury in patients with COVID‐19‐related anosmia, pharmacologic, or nonpharmacologic therapies to increase NAA levels using electroconvulsive therapy, cognitive behavioral therapy, and physical exercise or short‐course pharmacological therapies with lithium, valproate, or antipsychotics could be tried in these patients as they can lead to a widespread increase in brain NAA levels 24,25 …”

Section: Discussionmentioning

confidence: 99%

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Magnetic resonance spectroscopy findings of brain olfactory areas in patients with COVID‐19‐related anosmia: A preliminary comparative study

Nemati,

Haghani Dogahe,

Saberi

et al. 2023

World j. otorhinolaryngol.-head neck surg.

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Objectives2019 novel coronavirus disease (COVID‐19) infection is commonly associated with olfactory dysfunctions, but the basic pathogenesis of these complications remains controversial. This study seeks to evaluate the value of magnetic resonance spectroscopy (MRS) in determining the molecular neurometabolite alterations within the main brain olfactory areas in patients with COVID‐19‐related anosmia.MethodsIn a cross‐sectional study, seven patients with persistent COVID‐19‐related anosmia (mean age: 29.57 years) and seven healthy volunteers (mean age: 27.28 years) underwent MRS in which N‐acetyl‐aspartate (NAA), choline (Cho), creatine (Cr), and their ratios were measured in the anterior cingulate cortex, dorsolateral prefrontal cortex, orbitofrontal cortex (OFC), insular cortex, and ventromedial prefrontal cortex. Data were analyzed using TARQUIN software (version 4.3.10), and the results were compared with an independent sample t‐test and nonparametric Mann–Whitney test based on the normality of the MRS data distribution.ResultsThe mean duration of anosmia before imaging was 8.5 months in COVID‐19‐related anosmia group. MRS analysis elucidated a significant association between MRS findings within OFC and COVID‐19‐related anosmia (Pdisease < 0.01), and NAA was among the most important neurometabolites (Pinteraction = 0.006). Reduced levels of NAA (P < 0.001), Cr (P < 0.001) and NAA/Cho ratio (P = 0.007) within OFC characterize COVID‐19‐related anosmia.ConclusionsThis study emphasizes that MRS can be illuminating in COVID‐19‐related anosmia and indicates a possible association between central nervous system impairment and persistent COVID‐19‐related anosmia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Magnetic resonance spectroscopy findings of brain olfactory areas in patients with COVID‐19‐related anosmia: A preliminary comparative study

Nemati,

Haghani Dogahe,

Saberi

et al. 2023

World j. otorhinolaryngol.-head neck surg.

View full text Add to dashboard Cite

show abstract

“…According to a suggestive origin of injury in patients with COVID-19 related anosmia, pharmacologic or nonpharmacologic therapies in order to increase NAA levels using electroconvulsive therapy, cognitive behavioral therapy, and physical exercise or short-course pharmacological therapies with lithium, valproate, or antipsychotics could be tried in these patients as they can lead to a widespread increase in brain NAA levels 24,25 .…”

Section: Limitations and Comments Of The Studymentioning

confidence: 99%

Untitled Document

Dogahe

Nemati

Saberi

et al. 2022

Preprint

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Objectives: COVID-19 infection is commonly associated with olfactory dysfunctions, but the basic pathogenesis of these complications remains controversial. This study seeks to evaluate the value of magnetic resonance spectroscopy (MRS) in determining the molecular neurometabolite alterations within the main brain olfactory areas in patients with COVID-19 related anosmia. Methods: In a cross-sectional study, seven patients with persistent COVID19 related anosmia (mean age: 29.57 years) and seven healthy volunteers (mean age: 27.28 years) underwent MRS in which N-acetyl-aspartate (NAA), choline (Cho), creatine (Cr) and their ratios were measured in the anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex (OFC), insular cortex (IC) and ventromedial prefrontal cortex (VMPFC). Data were analyzed using TARQUIN software (version 4.3.10), and the results were compared with an independent sample T test and non-parametric Mann-Whitney test based on the normality of the MRS data distribution. Results: The mean duration of anosmia before imaging was 8.5 months. MRS analysis elucidated a significant association between MRS findings within OFC and COVID-19 related anosmia (Pdisease<0.01), and NAA was among the most important neurometabolites (Pinteraction=0.006). Reduced levels of NAA (P<0.001), Cr (P<0.001) and NAA/Cho ratio (p=0.007) within OFC characterize COVID-19 related anosmia. Conclusions: This study emphasizes that MRS can be illuminating in COVID-19 related anosmia and indicates a possible association between central nervous system impairment and persistent COVID-19 related anosmia.

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