Magnetic tracking of gastrointestinal motility

Brinck, Christian Emil; Mark, Esben Bolvig; Klinge, Mette Winther; Ejerskov, Cecilie; Sutter, Nanna; Schlageter, Vincent; Drewes, Asbjørn Mohr; Krogh, Klaus

doi:10.1088/1361-6579/abcd1e

Cited by 10 publications

(15 citation statements)

References 70 publications

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“…Propagation of luminal content within the GI tract is expressed by the change in orientation of the capsules and capsule movement velocity. The characteristic contraction frequency in each GI segment is determined by angular rotations of the capsule providing information about anatomical landmarks [ 111 , 112 ]. The 3D-Transit system can track three capsules simultaneously without interference, and the measures of transit times are found to be valid, reproducible, and comparable to transit times measured with radio-opaque markers [ 110 ].…”

Section: Emerging Methods For Assessment Of Gastroenteropathymentioning

confidence: 99%

“…Normative data on healthy subjects are available and comparable to normative data on transit times from the wireless motility capsule [ 100 , 113 , 114 ]. The main drawbacks of using this pan-enteric, diagnostic tool is the time-consuming and challenging data analysis, no CE-marking, and no availability outside research settings [ 112 ].…”

Section: Emerging Methods For Assessment Of Gastroenteropathymentioning

confidence: 99%

“…3D-Transit has been applied to assess transit times and contraction patterns in various GI disorders and among these in patients with gastroenteropathy related to AD [ 112 ]. Patients with type 1 DM are shown to have prolonged gastric emptying time, colonic transit time, and whole gut transit time mainly due to an increased number of retrograde movements within the right colon [ 115 ].…”

Section: Emerging Methods For Assessment Of Gastroenteropathymentioning

confidence: 99%

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Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives

Kornum

Terkelsen

Bertoli

et al. 2021

JCM

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The autonomic nervous system delicately regulates the function of several target organs, including the gastrointestinal tract. Thus, nerve lesions or other nerve pathologies may cause autonomic dysfunction (AD). Some of the most common causes of AD are diabetes mellitus and α-synucleinopathies such as Parkinson’s disease. Widespread dysmotility throughout the gastrointestinal tract is a common finding in AD, but no commercially available method exists for direct verification of enteric dysfunction. Thus, assessing segmental enteric physiological function is recommended to aid diagnostics and guide treatment. Several established assessment methods exist, but disadvantages such as lack of standardization, exposure to radiation, advanced data interpretation, or high cost, limit their utility. Emerging methods, including high-resolution colonic manometry, 3D-transit, advanced imaging methods, analysis of gut biopsies, and microbiota, may all assist in the evaluation of gastroenteropathy related to AD. This review provides an overview of established and emerging assessment methods of physiological function within the gut and assessment methods of autonomic neuropathy outside the gut, especially in regards to clinical performance, strengths, and limitations for each method.

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Section: Emerging Methods For Assessment Of Gastroenteropathymentioning

confidence: 99%

Section: Emerging Methods For Assessment Of Gastroenteropathymentioning

confidence: 99%

Section: Emerging Methods For Assessment Of Gastroenteropathymentioning

confidence: 99%

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Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives

Kornum

Terkelsen

Bertoli

et al. 2021

JCM

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“…The use of electromagnetic capsules, like the electromagnetic Motilis 3D-Transit system, to measure colonic transit has been reviewed elsewhere [177]. The advantage of this method is the spatiotemporal resolution that allows assessment of regional colonic transit times which is not possible with other ambulatory methods, such as the wireless motility capsule.…”

Section: Use Of (Electro)magnetic Capsules To Measure Colonic Transitmentioning

confidence: 99%

In vivo models to evaluate ingestible devices: Present status and current trends

Stamatopoulos

O’Farrell

Simmons

et al. 2021

Advanced Drug Delivery Reviews

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Link to publication on Research at Birmingham portal General rightsUnless a licence is specified above, all rights (including copyright and moral rights) in this document are retained by the authors and/or the copyright holders. The express permission of the copyright holder must be obtained for any use of this material other than for purposes permitted by law.• Users may freely distribute the URL that is used to identify this publication.• Users may download and/or print one copy of the publication from the University of Birmingham research portal for the purpose of private study or non-commercial research.• User may use extracts from the document in line with the concept of 'fair dealing' under the Copyright, Designs and Patents Act 1988 (?) • Users may not further distribute the material nor use it for the purposes of commercial gain.Where a licence is displayed above, please note the terms and conditions of the licence govern your use of this document.When citing, please reference the published version. Take down policyWhile the University of Birmingham exercises care and attention in making items available there are rare occasions when an item has been uploaded in error or has been deemed to be commercially or otherwise sensitive.

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“…Gastrointestinal (GI) motility is usually described in terms of regional transit or changes of intraluminal pressure. Motility processes have been widely investigated with technologies including manometry, 1,2 radiopaque markers, 3 and ingestible wireless capsule devices 4–8 9–15 .…”

Section: Introductionmentioning

confidence: 99%

Contractility patterns and gastrointestinal movements monitored by a combined magnetic tracking and motility testing unit

Liao

Mark

Nedergaard

et al. 2021

Neurogastroenterology Motil

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Background: Ingestible wireless capsules, including the 3D-transit magnetic capsule and the wireless motility capsule (WMC), describe gastrointestinal (GI) motility from changes in position or pressure. This study aimed to combine information on contractile events in terms of position (assessed with the 3D-transit) and change in pressure (assessed with the WMC) throughout the entire GI tract. Methods:The 3D-transit capsule and WMC were combined into a single-wireless unit system. Three-dimensional space-time coordinates, pressure, and pH data from a pilot case were analyzed as the combined unit passed the GI tract. Two single and three continuous contraction patterns were defined according to pressure changes and quantified through the GI tract. Key results:The combined unit was well tolerated and provided information on contractions throughout the gut. Single contraction patterns with no significant progressive movement of the unit were most prevalent in the stomach and the rectosigmoid colon. During the continuous contraction patterns, the unit moved in an antegrade or retrograde direction. Longer distance and higher velocity were seen during antegrade than during retrograde movements. The motility indices (as measured with WMC) in combined ascending, transverse and descending colon showed a positive linear association (r = 0.7) to the capsule movements (as measured with 3D-transit). Conclusions & inferences:The combined system provides synchronous information about movements and gut contractions. These measurements can be used to extract more information from existing recordings and may enhance our understanding of GI motility in health and disease.

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Magnetic tracking of gastrointestinal motility

Cited by 10 publications

References 70 publications

Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives

Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives

In vivo models to evaluate ingestible devices: Present status and current trends

Contractility patterns and gastrointestinal movements monitored by a combined magnetic tracking and motility testing unit

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