Magnetically Controlled Strategies for Enhanced Tissue Vascularization

Abstract

Tissue vascularization plays a critical role in the regeneration and repair of damaged tissues. However, in certain instances of tissue injury, the pace and effectiveness of vascularization can be limited. Innovative strategies leveraging magnetic fields and magnetic nanoparticles (MNPs) are devised to enhance the efficacy of tissue vascularization. This review explores the potential of magnetic field‐assisted strategies in augmenting tissue vascularization and repair. Direct application of static or dynamic magnetic fields, alone or in combination with MNPs, offers a means to modulate cellular behaviors and gene expression, thereby promoting angiogenesis and tissue regeneration. Techniques such as cell labeling, gene delivery using MNPs, and magnetic targeting have shown promise in efficiently repairing various ischemic tissue injuries by enhancing tissue vascularization. These strategies have broad applications in bone and skin tissue regeneration, limb ischemia treatment, myocardial injury treatment, and diabetic wound therapy. By summarizing recent advancements in magnetically controlled strategies, this review aims to shed light on their future prospects in tissue regeneration and clinical treatment.