Magnetically responsive, sorafenib loaded alginate microspheres for hepatocellular carcinoma treatment

Alpdemir, Şükran; Vural, Tayfun; Kara, Göknur; Bayram, Cem; Haberal, Erdem; Denkbaş, Emir Baki

doi:10.1049/iet-nbt.2020.0139

Cited by 12 publications

(7 citation statements)

References 25 publications

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“…Moreover, the presence of amenable functional groups for better reactivity for further functionalization was added advantage, which was utilized to conjugate optical probe to use it as a multimodal imaging nanoprobe. Till date, very few reports are available on alginate functionalized magnetic nanoparticles 30 – 32 and none extended the same to the development of multimodal nanoprobe for diagnosis and therapy, and has proven the concept in in vivo models.…”

Section: Resultsmentioning

confidence: 99%

Near infrared-emitting multimodal nanosystem for in vitro magnetic hyperthermia of hepatocellular carcinoma and dual imaging of in vivo liver fibrosis

Nazeer

Saraswathy

Nimi

et al. 2023

Sci Rep

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Prolonged usage of traditional nanomaterials in the biological field has posed several short- and long-term toxicity issues. Over the past few years, smart nanomaterials (SNs) with controlled physical, chemical, and biological features have been synthesized in an effort to allay these challenges. The current study seeks to develop theranostic SNs based on iron oxide to enable simultaneous magnetic hyperthermia and magnetic resonance imaging (MRI), for chronic liver damage like liver fibrosis which is a major risk factor for hepatocellular carcinoma. To accomplish this, superparamagnetic iron oxide nanoparticles (SPIONs) were prepared, coated with a biocompatible and naturally occurring polysaccharide, alginate. The resultant material, ASPIONs were evaluated in terms of physicochemical, magnetic and biological properties. A hydrodynamic diameter of 40 nm and a transverse proton relaxation rate of 117.84 mM−1 s−1 pronounces the use of ASPIONs as an efficient MRI contrast agent. In the presence of alternating current of 300 A, ASPIONs could elevate the temperature to 45 °C or more, with the possibility of hyperthermia based therapeutic approach. Magnetic therapeutic and imaging potential of ASPIONs were further evaluated respectively in vitro and in vivo in HepG2 carcinoma cells and animal models of liver fibrosis, respectively. Finally, to introduce dual imaging capability along with magnetic properties, ASPIONs were conjugated with near infrared (NIR) dye Atto 700 and evaluated its optical imaging efficiency in animal model of liver fibrosis. Histological analysis further confirmed the liver targeting efficacy of the developed SNs for Magnetic theranostics and optical imaging as well as proved its short-term safety, in vivo.

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Section: Resultsmentioning

confidence: 99%

Near infrared-emitting multimodal nanosystem for in vitro magnetic hyperthermia of hepatocellular carcinoma and dual imaging of in vivo liver fibrosis

Nazeer

Saraswathy

Nimi

et al. 2023

Sci Rep

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“…Since the release profile was studied at pH 7.4, which is the normal pH of serum, not of the tumor environment, this could raise the question of the safety of the system, since SOR could be released in serum before reaching the tumor. The formulation exhibited cytotoxicity towards HepG2 cells; however, no comparison to SOR alone was performed [ 179 ].…”

Section: Chemotherapy Delivery Using Magnetic Nanoparticlesmentioning

confidence: 99%

Recent Advances in the Development of Drug Delivery Applications of Magnetic Nanomaterials

et al. 2023

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With the predicted rise in the incidence of cancer, there is an ever-growing need for new cancer treatment strategies. Recently, magnetic nanoparticles have stood out as promising nanostructures for imaging and drug delivery systems as they possess unique properties. Moreover, magnetic nanomaterials functionalized with other compounds can lead to multicomponent nanoparticles with innovative structures and synergetic performance. The incorporation of chemotherapeutic drugs or RNA in magnetic drug delivery systems represents a promising alternative that can increase efficiency and reduce the side effects of anticancer therapy. This review presents a critical overview of the recent literature concerning the advancements in the field of magnetic nanoparticles used in drug delivery, with a focus on their classification, characteristics, synthesis and functionalization methods, limitations, and examples of magnetic drug delivery systems incorporating chemotherapeutics or RNA.

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“…Other studies also studied the effect that polysaccharide microparticles with iron oxide nanoparticles had on different types of cells. Alpdemir et al [21] found that alginate microparticles with SPIONs also had no negative effects on HEPG2 liver cancer and L929 fibroblast cell lines. However, in their study, they dispersed SPIONs in a precrosslinked alginate solution with an initial concentration of 5 mg/mL of the SPIONs in the alginate solution.…”

Section: Cytotoxicity Assaysmentioning

confidence: 99%

“…These membranes were able to increase the surrounding temperature upon the application of an AMF and exhibited no significant cytotoxicity. Regarding the encapsulation/adsorption of mNPs into polymeric microparticles, Alpdemir et al [21] developed alginate microparticles with mNPs for sorafenib release in cancer treatments. The mNPs conferred hyperthermic capabilities to the polymeric microparticles, leading to an increase in temperature of 4 • C. Xue et al [22] encapsulated mNPs within alginate-chitosan microspheres for doxorubicin (DOX) release in breast cancer treatments, where the application of a remote AMF affected the DOX release, enabling the regulation of release profiles.…”

Section: Introductionmentioning

confidence: 99%

Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications

Carrelo,

Escoval,

Vieira

et al. 2023

Gels

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Cancer is a disease that continues to greatly impact our society. Developing new and more personalized treatment options is crucial to decreasing the cancer burden. In this study, we combined magnetic polysaccharide microparticles with a Pluronic thermoresponsive hydrogel to develop a multifunctional, injectable drug delivery system (DDS) for magnetic hyperthermia applications. Gellan gum and alginate microparticles were loaded with superparamagnetic iron oxide nanoparticles (SPIONs) with and without coating. The magnetic microparticles’ registered temperature increases up to 4 °C upon the application of an alternating magnetic field. These magnetic microparticles were mixed with drug-loaded microparticles, and, subsequently, this mixture was embedded within a Pluronic thermoresponsive hydrogel that is capable of being in the gel state at 37 °C. The proposed DDS was capable of slowly releasing methylene blue, used as a model drug, for up to 9 days. The developed hydrogel/microparticle system had a smaller rate of drug release compared with microparticles alone. This system proved to be a potential thermoresponsive DDS suitable for magnetic hyperthermia applications, thus enabling a synergistic treatment for cancer.

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Magnetically responsive, sorafenib loaded alginate microspheres for hepatocellular carcinoma treatment

Cited by 12 publications

References 25 publications

Near infrared-emitting multimodal nanosystem for in vitro magnetic hyperthermia of hepatocellular carcinoma and dual imaging of in vivo liver fibrosis

Near infrared-emitting multimodal nanosystem for in vitro magnetic hyperthermia of hepatocellular carcinoma and dual imaging of in vivo liver fibrosis

Recent Advances in the Development of Drug Delivery Applications of Magnetic Nanomaterials

Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications

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