Magnetised Thermo Responsive Lipid Vehicles for Targeted and Controlled Lung Drug Delivery

Upadhyay, Dhrumil; Scalia, Santo; Vogel, Robert; Wheate, Nial J.; Salama, Rania; Young, Paul M.; Traini, Daniela; Chrzanowski, Wojciech

doi:10.1007/s11095-012-0774-9

Cited by 52 publications

(32 citation statements)

References 40 publications

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“…(7,8) In particular, a growing community of researchers has been investigating the potential for targeted aerosol delivery to specific lung regions using SPIONs in combination with target-directed magnetic gradient fields. (9,10) SPIONs can also serve as theranostic agents, i.e., as both diagnostic and therapeutic agents, where their inherent magnetic properties can provide image contrast in magnetic resonance imaging and thermal ablation in magnetic fluid hyperthermia therapy. (11) Moreover, as SPIONs can be chemically modified or engineered for simultaneous biomedical functions, their application as aerosolized chemotherapeutics may be used to increase drug dosage to the lungs while reducing systemic side effects.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Characterization of Nebulized Superparamagnetic Iron Oxide Nanoparticles (SPIONs)

Graczyk

Bryan

Lewinski

et al. 2015

Journal of Aerosol Medicine and Pulmonary Drug Delivery

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Background: Aerosol-mediated delivery of nano-based therapeutics to the lung has emerged as a promising alternative for treatment and prevention of lung diseases. Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted significant attention for such applications due to their biocompatibility and magnetic properties. However, information is lacking about the characteristics of nebulized SPIONs for use as a therapeutic aerosol. To address this need, we conducted a physicochemical characterization of nebulized Rienso, a SPION-based formulation for intravenous treatment of anemia. Methods: Four different concentrations of SPION suspensions were nebulized with a one-jet nebulizer. Particle size was measured in suspension by transmission electron microscopy (TEM), photon correlation spectroscopy (PCS), and nanoparticle tracking analysis (NTA), and in the aerosol by a scanning mobility particle sizer (SMPS). Results: The average particle size in suspension as measured by TEM, PCS, and NTA was 9 -2 nm, 27 -7 nm, and 56 -10 nm, respectively. The particle size in suspension remained the same before and after the nebulization process. However, after aerosol collection in an impinger, the suspended particle size increased to 159 -46 nm as measured by NTA. The aerosol particle concentration increased linearly with increasing suspension concentration, and the aerodynamic diameter remained relatively stable at around 75 nm as measured by SMPS. Conclusions: We demonstrated that the total number and particle size in the aerosol were modulated as a function of the initial concentration in the nebulizer. The data obtained mark the first known independent characterization of nebulized Rienso and, as such, provide critical information on the behavior of Rienso nanoparticles in an aerosol. The data obtained in this study add new knowledge to the existing body of literature on potential applications of SPION suspensions as inhaled aerosol therapeutics.

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Section: Introductionmentioning

confidence: 99%

Physicochemical Characterization of Nebulized Superparamagnetic Iron Oxide Nanoparticles (SPIONs)

Graczyk

Bryan

Lewinski

et al. 2015

Journal of Aerosol Medicine and Pulmonary Drug Delivery

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“…Upadhyay et al [69] investigated the potential of nanoformulation with SPION and a drug within a lipid matrix as a potentially targetable and thermosensitive inhalable drug delivery system. The therapeutic nanoparticle was characterised by TRPS.…”

Section: Trps In Drug Delivery and Drug Development Applicationsmentioning

confidence: 99%

Tunable Resistive Pulse Sensing: Potential Applications in Nanomedicine

Sivakumaran

Platt

2016

Nanomedicine (Lond.)

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An accurate characterisation of nanomaterials used in clinical diagnosis and therapeutics is of paramount importance to realise the full potential of nanotechnology in medicine and to avoid unexpected and potentially harmful toxic effects due to these materials. A number of technical modalities are currently in use to study the physical, chemical and biological properties of nanomaterials but they all have advantages and disadvantages. In this review, we discuss the potential of a relative newcomer, Tunable Resistive Pulse Sensing (TRPS), for the characterisation of nanomaterials and its applications in nanodiagnostics.

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“…Although Dames et al determined dry powder formulations of SPIONs will not undergo magnetic direction, Upadhyay et al formulated drug and SPION containing lipid microparticles for dry powder inhaler based lung delivery [90]. Cascade impactor measurements showed that 30% of the inhaler-generated aerosol consisted of particles with a diameter < 2.5 µm, which would deposit deeper into the lungs.…”

Section: Respiratory Medicine Applications Of Spionsmentioning

confidence: 99%

Human inhalation exposure to iron oxide particles

2013

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Abstract:In the past decade, many studies have been conducted to determine the health effects induced by exposure to engineered nanomaterials (NMs). Specifically for exposure via inhalation, numerous in vitro and animal in vivo inhalation toxicity studies on several types of NMs have been published. However, these results are not easily extrapolated to judge the effects of inhaling NMs in humans, and few published studies on the human response to inhalation of NMs exist. Given the emergence of more industries utilizing iron oxide nanoparticles as well as more nanomedicine applications of superparamagnetic iron oxide nanoparticles (SPIONs), this review presents an overview of the inhalation studies that have been conducted in humans on iron oxides. Both occupational exposure studies on complex iron oxide dusts and fumes, as well as human clinical studies on aerosolized, micron-size iron oxide particles are discussed. Iron oxide particles have not been described to elicit acute inhalation response nor promote lung disease after chronic exposure. The few human clinical studies comparing inhalation of fine and ultrafine metal oxide particles report no acute changes in the health parameters measured. Taken together existing evidence suggests that controlled human exposure to iron oxide nanoparticles, such as SPIONs, could be conducted safely.

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Magnetised Thermo Responsive Lipid Vehicles for Targeted and Controlled Lung Drug Delivery

Cited by 52 publications

References 40 publications

Physicochemical Characterization of Nebulized Superparamagnetic Iron Oxide Nanoparticles (SPIONs)

Physicochemical Characterization of Nebulized Superparamagnetic Iron Oxide Nanoparticles (SPIONs)

Tunable Resistive Pulse Sensing: Potential Applications in Nanomedicine

Human inhalation exposure to iron oxide particles

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