Magnetization Transfer Ratio in Early Period of Parkinson Disease

Anık, Yonca; İşeri, Pervin; Demırcı, Ali; Komşuoğlu, Sezer; İnan, Nagihan

doi:10.1016/j.acra.2006.11.005

Cited by 45 publications

(38 citation statements)

References 12 publications

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“…This hypothesis is supported by monkey studies showing that SNr output indirectly targets the dorsolateral prefrontal cortex and that neurons in the SNr demonstrate activity corresponding to the activity observed in the dorsolateral prefrontal cortex during spatial memory tasks (Middleton & Strick, 2000). There is evidence that the SNr begins to degenerate early in PD (Anik, Iseri, Demirci, Komsuoglu, & Inan, 2007). Our volumetric measurements include a portion of the SNr along with the SNc, which may help to explain why they are more related to SDR than to motor performance.…”

Section: Discussionsupporting

confidence: 65%

Motor asymmetry and substantia nigra volume are related to spatial delayed response performance in Parkinson disease

Foster

Black

Antenor-Dorsey

et al. 2008

Brain and Cognition

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Studies suggest motor deficit asymmetry may help predict the pattern of cognitive impairment in individuals with Parkinson disease (PD). We tested this hypothesis using a highly validated and sensitive spatial memory task, spatial delayed response (SDR), and clinical and neuroimaging measures of PD asymmetry. We predicted SDR performance would be more impaired by PDrelated changes in the right side of the brain than in the left. PD (n = 35) and control (n = 28) participants performed the SDR task. PD participants either had worse motor deficits on the right (RPD) or left (LPD) side of the body. Some participants also had magnetic resonance imaging for measurement of their substantia nigra (SN) volumes. The LPD group performed worse on the SDR task than the RPD and control groups. Right SN volume accounted for a unique and significant portion of the variance in SDR error, with smaller volume predicting poorer performance. In conclusion, left motor dysfunction and smaller right SN volume are associated with poorer spatial memory.

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Section: Discussionsupporting

confidence: 65%

Motor asymmetry and substantia nigra volume are related to spatial delayed response performance in Parkinson disease

Foster

Black

Antenor-Dorsey

et al. 2008

Brain and Cognition

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“…It is noteworthy that the amount of myelin varies substantially in areas with high iron concentration as indicated by myelin stains (Schaltenbrand et al, 1977;Deistung et al, 2013), magnetisation transfer (MT; reflecting loss of macromolecular content) (Anik et al, 2007) and proton-induced X-ray emission (PIXE) maps (Stüber et al, 2014). In this scenario the presence of myelin may also locally attenuate susceptibility values, thus, it is plausible that in such regions, QSM may underestimate the true impact of iron accumulation.…”

Section: Discussionmentioning

confidence: 99%

High-resolution characterisation of the aging brain using simultaneous quantitative susceptibility mapping (QSM) and R2* measurements at 7 T

et al. 2016

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Quantitative susceptibility mapping (QSM) has recently emerged as a novel magnetic resonance imaging (MRI) method to detect non-haem iron deposition, calcifications, demyelination and vascular lesions in the brain. It has been suggested that QSM is more sensitive than the more conventional quantifiable MRI measure, namely the transverse relaxation rate, R2*. Here, we conducted the first high-resolution, whole-brain, simultaneously acquired, comparative study of the two techniques using 7 Tesla MRI. We asked which of the two techniques would be more sensitive to explore global differences in tissue composition in elderly adults relative to young subjects. Both QSM and R2* revealed strong agerelated differences in subcortical regions, hippocampus and cortical grey matter, particularly in superior frontal regions, motor/premotor cortices, insula and cerebellar regions. Within the basal ganglia system-but also hippocampus and cerebellar dentate nucleus-, QSM was largely in agreement with R2* with the exception of the globus pallidus. QSM, however, provided superior anatomical contrast and revealed age-related differences in the thalamus and in white matter, which were otherwise largely undetected by R2* measurements. In contrast, in occipital cortex, age-related differences were much greater with R2* compared to QSM. The present study, therefore, demonstrated that in vivo QSM using ultra-high field MRI provides a novel means to characterize age-related differences in the human brain, but also combining QSM and R2* using multigradient recalled echo imaging can potentially provide a more complete picture of mineralization, demyelination and/or vascular alterations in aging and disease.

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“…More recently, significant reduction of MTR was found in the substantia nigra, red nucleus, and pons in PD patients in the first year of diagnosis, indicating that MTR analysis may be a useful technique in the assessment of damage in patients with early PD. 155 Reduced MTR values have also been found in the pons, middle cerebellar peduncle, putamen and WM of the precentral gyrus in patients with multiple system atrophy. 156 In this latter group of patients, 155 MTR values of the corticospinal tract were significantly lower in those with corresponding pyramidal signs compared with those without; similarly, MTR values of the basal ganglia were significantly lower in patients with corresponding parkinsonism than in those without it.…”

Section: Parkinson's Disease (Pd) and Allied Conditionsmentioning

confidence: 99%

Magnetization Transfer Magnetic Resonance Imaging of the Brain, Spinal Cord, and Optic Nerve

Filippi

Rocca

2007

Neurotherapeutics

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Summary:Magnetic resonance imaging is highly sensitive in revealing CNS abnormalities associated with several neurological conditions, but lacks specificity for their pathological substrates. In addition, MRI does not allow evaluation of the presence and extent of damage in regions that appear normal on conventional MRI sequences and that postmortem studies have shown to be affected by pathology. Quantitative MR-based techniques with increased pathological specificity to the heterogeneous substrates of CNS pathology have the potential to overcome such limitations. Among these techniques, one of the most extensively used for the assessment of CNS disorders is magnetization transfer MRI (MT-MRI). The application of this technique for the assessment of damage in macroscopic lesions, in normal-appearing white and gray matter, and in the spinal cord and optic nerve of patients with several neurological conditions is providing important in vivo information-dramatically improving our understanding of the factors associated with the appearance of clinical symptoms and the accumulation of irreversible disability. MT-MRI also has the potential to contribute to the diagnostic evaluation of several neurological conditions and to improve our ability to monitor treatment efficacy in experimental trials.

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Magnetization Transfer Ratio in Early Period of Parkinson Disease

Cited by 45 publications

References 12 publications

Motor asymmetry and substantia nigra volume are related to spatial delayed response performance in Parkinson disease

Motor asymmetry and substantia nigra volume are related to spatial delayed response performance in Parkinson disease

High-resolution characterisation of the aging brain using simultaneous quantitative susceptibility mapping (QSM) and R2* measurements at 7 T

Magnetization Transfer Magnetic Resonance Imaging of the Brain, Spinal Cord, and Optic Nerve

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