Magneto-thermally responsive hydrogels for bladder cancer treatment: Therapeutic efficacy and in vivo biodistribution

Jaiswal, Manish K.; Pradhan, Lina; Vasavada, Shaleen; De, Mrinmoy; Sarma, Haladhar Dev; Prakash, Anand; Bahadur, D.; Dravid, Vinayak P.

doi:10.1016/j.colsurfb.2015.09.058

Cited by 19 publications

(18 citation statements)

References 37 publications

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“…Metastatic bladder cancer has been treated with chemotherapeutic drugs, but no higher than 15% of the patients show long-term disease-free survival (Dinney et al, 2004 ; Zhou et al, 2013 ). The most popular anticancer drugs, such as doxorubicin (DOX) and paclitaxel, have high toxicity and low specificity, leading to serious toxic side effects (Jaiswal et al, 2015 ; Zhang et al, 2015b ; Zhu et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Polydopamine and peptide decorated doxorubicin-loaded mesoporous silica nanoparticles as a targeted drug delivery system for bladder cancer therapy

Wei

Gao

Wang³

et al. 2017

Drug Delivery

137

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We reported a simple polydopamine (PDA)-based surface modification method to prepare novel targeted doxorubicin-loaded mesoporous silica nanoparticles and peptide CSNRDARRC conjugation (DOX-loaded MSNs@PDA-PEP) for enhancing the therapeutic effects on bladder cancer. Drug-loaded NPs were characterized in terms of size, size distribution, zeta potential, transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) surface area and drug loading content. In vitro drug release indicated that DOX-loaded MSNs@PDA and MSNs@PDA-PEP had similar release kinetic profiles of DOX. The PDA coating well controlled DOX release and was highly sensitive to pH value. Confocal laser scanning microscopy (CLSM) showed that drug-loaded MSNs could be internalized by human bladder cancer cell line HT-1376, and DOX-loaded MSNs@PDA-PEP had the highest cellular uptake efficiency due to ligand-receptor recognition. The antitumor effects of DOX-loaded nanoparticles were evaluated by the MTT assay in vitro and by a xenograft tumor model in vivo, demonstrating that targeted nanocarriers DOX-loaded MSNs@PDA-PEP were significantly superior to free DOX and DOX-loaded MSNs@PDA. The novel DOX-loaded MSNs@PDA-PEP, which specifically recognized HT-1376 cells, can be used as a potential targeted drug delivery system for bladder cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Polydopamine and peptide decorated doxorubicin-loaded mesoporous silica nanoparticles as a targeted drug delivery system for bladder cancer therapy

Wei

Gao

Wang³

et al. 2017

Drug Delivery

137

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“…Jaiswal et al [ 38 ] developed a magnetogel based on poly( N -isopropylacrylamide) and Fe 3 O 4 nanoparticles functionalized with polyethylene glycol (PEG), which was loaded with doxorubicin and incubated with bladder cancer T-24 cell lines, to evaluate the effect of an external radiofrequency field and applied in swiss mice model via tail vein to monitor magnetogel accumulation. The authors reported that one-hour application of a 375 Oe radiofrequency field resulted in 40% cells under apoptotic condition 24 h after treatment, compared to only 13% without radiofrequency field exposure, attaining a 95% cell death due to synergy between the heat generated by the RF field and doxorubicin release [ 38 ]. In addition, the magnetogel was found to preferentially accumulate in lungs 1 h after administration, with the heart showing a similar trend and liver showing no contrast enhancement for 7 days ( Figure 9 ) [ 38 ].…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

“…The authors reported that one-hour application of a 375 Oe radiofrequency field resulted in 40% cells under apoptotic condition 24 h after treatment, compared to only 13% without radiofrequency field exposure, attaining a 95% cell death due to synergy between the heat generated by the RF field and doxorubicin release [ 38 ]. In addition, the magnetogel was found to preferentially accumulate in lungs 1 h after administration, with the heart showing a similar trend and liver showing no contrast enhancement for 7 days ( Figure 9 ) [ 38 ].…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

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Magnetogels: Prospects and Main Challenges in Biomedical Applications

et al. 2018

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Drug delivery nanosystems have been thriving in recent years as a promising application in therapeutics, seeking to solve the lack of specificity of conventional chemotherapy targeting and add further features such as enhanced magnetic resonance imaging, biosensing and hyperthermia. The combination of magnetic nanoparticles and hydrogels introduces a new generation of nanosystems, the magnetogels, which combine the advantages of both nanomaterials, apart from showing interesting properties unobtainable when both systems are separated. The presence of magnetic nanoparticles allows the control and targeting of the nanosystem to a specific location by an externally applied magnetic field gradient. Moreover, the application of an alternating magnetic field (AMF) not only allows therapy through hyperthermia, but also enhances drug delivery and chemotherapeutic desired effects, which combined with the hydrogel specificity, confer a high therapeutic efficiency. Therefore, the present review summarizes the magnetogels properties and critically discusses their current and recent biomedical applications, apart from an outlook on future goals and perspectives.

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“…Hydrogels are already used for different applications in biomedicine, e.g., as contact lenses, wound dressings, hygiene products, drug delivery systems, and for the tissue engineering . For tissue engineering applications, hydrogels can be produced by using synthetic polymers such as polyethylene glycol, polyvinyl alcohol, poly( N ‐isopropylacrylamide), poly(hydroxyethyl methacrylate), or polypropylene fumarate . However, the in vivo application of scaffolds made of synthetic polymers, e.g., poly(glycolic acid), can be limited due to their toxic degradation products .…”

Section: Introductionmentioning

confidence: 99%

Generation of Large‐Scale DNA Hydrogels with Excellent Blood and Cell Compatibility

Stoll¹,

Steinle²,

Stang³

et al. 2016

Macromolecular Bioscience

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Hemocompatibility and cytocompatibility of biomaterials codetermine the success of tissue engineering applications. DNA, the natural component of our cells, is an auspicious biomaterial for the generation of designable scaffolds with tailorable characteristics. In this study, a combination of rolling circle amplification and multiprimed chain amplification is used to generate hydrogels at centimeter scale consisting solely of DNA. Using an in vitro rotation model and fresh human blood, the reaction of the hemostatic system on DNA hydrogels is analyzed. The measurements of hemolysis, platelets activation, and the activation of the complement, coagulation, and neutrophils using enzyme-linked immunosorbent assays demonstrate excellent hemocompatibility. In addition, the cytocompatibility of the DNA hydrogels is tested by indirect contact (agar diffusion tests) and material extract experiments with L929 murine fibroblasts according to the ISO 10993-5 specifications and no negative impact on the cell viability is detected. These results indicate the promising potential of DNA hydrogels as biomaterials for versatile applications in the field of regenerative medicine.

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Magneto-thermally responsive hydrogels for bladder cancer treatment: Therapeutic efficacy and in vivo biodistribution

Cited by 19 publications

References 37 publications

Polydopamine and peptide decorated doxorubicin-loaded mesoporous silica nanoparticles as a targeted drug delivery system for bladder cancer therapy

Polydopamine and peptide decorated doxorubicin-loaded mesoporous silica nanoparticles as a targeted drug delivery system for bladder cancer therapy

Magnetogels: Prospects and Main Challenges in Biomedical Applications

Generation of Large‐Scale DNA Hydrogels with Excellent Blood and Cell Compatibility

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