Magnetocardiography in Unshielded Setting: Heart Electrical Image Based on 2-D and 3-D Data in Comparison with Perfusion Image Based on PET Results – Clinical Cases

Chaikovsky, Illya; Примин, М. А.; Nedayvoda, I. V.; Budnyk, Mykola

doi:10.5772/30122

Cited by 4 publications

(5 citation statements)

References 5 publications

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“…Among them, the CMI nine-channel prototype was the first to get an FDA approval for the measurement of human cardiac MF and was used for the first MCG multicenter clinical trial in the United States and in Europe as well as installed in a cardiology department in China. Most of the current lines of research aimed to electively investigate the predictive accuracy of MCG for the detection of myocardial ischemia ( 71 , 72 , 74 , 76 – 78 , 211 – 216 ) also during effort test ( 217 ) and the emergency triage of patients with chest pain ( 87 , 88 ). Interesting data were also obtained in patients with non-ischemic arrhythmogenic cardiomyopathy ( 96 , 138 , 218 , 219 ), confirmed also by more recent multichannel MCG studies in MSRs ( 220 , 221 ).…”

Section: Unshielded Mcg: the Pastmentioning

confidence: 99%

“…On the other hand, most clinicians were skeptical and considered unnecessary the sophisticated and expensive MCG technology, given the ready availability of more affordable, and overall well-established diagnostic tools (although mostly invasive) for cardiac clinical electrophysiology. Only a small group of “MCG believers” envisioning the yet unleashed innovative diagnostic power of this technology (if made available to the patient's bedside) devoted their main research focus to the development and validation of less expensive and more scalable multichannel MCG mapping systems, reliably operated in unshielded hospital environments ( 66 – 78 ). This pioneering vision of MCG mapping as a unique novel method for non-invasive 3D electroanatomical imaging (EAI) and localization of cardiac electrophysiological mechanisms with its potential to guide “aimed” myocardial biopsy and interventional transcatheter treatment of arrhythmogenic substrates prompted the development of a novel and easy-to-use unshielded MCG multichannel prototype reliable even in catheterization laboratories where noisy radiological and interventional equipment were necessary ( 79 ).…”

Section: Introductionmentioning

confidence: 99%

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Clinical magnetocardiography: the unshielded bet—past, present, and future

Brisinda,

Fenici,

Fenici

2023

Front. Cardiovasc. Med.

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Magnetocardiography (MCG), which is nowadays 60 years old, has not yet been fully accepted as a clinical tool. Nevertheless, a large body of research and several clinical trials have demonstrated its reliability in providing additional diagnostic electrophysiological information if compared with conventional non-invasive electrocardiographic methods. Since the beginning, one major objective difficulty has been the need to clean the weak cardiac magnetic signals from the much higher environmental noise, especially that of urban and hospital environments. The obvious solution to record the magnetocardiogram in highly performant magnetically shielded rooms has provided the ideal setup for decades of research demonstrating the diagnostic potential of this technology. However, only a few clinical institutions have had the resources to install and run routinely such highly expensive and technically demanding systems. Therefore, increasing attempts have been made to develop cheaper alternatives to improve the magnetic signal-to-noise ratio allowing MCG in unshielded hospital environments. In this article, the most relevant milestones in the MCG's journey are reviewed, addressing the possible reasons beyond the currently long-lasting difficulty to reach a clinical breakthrough and leveraging the authors’ personal experience since the early 1980s attempting to finally bring MCG to the patient's bedside for many years thus far. Their nearly four decades of foundational experimental and clinical research between shielded and unshielded solutions are summarized and referenced, following the original vision that MCG had to be intended as an unrivaled method for contactless assessment of the cardiac electrophysiology and as an advanced method for non-invasive electroanatomical imaging, through multimodal integration with other non-fluoroscopic imaging techniques. Whereas all the above accounts for the past, with the available innovative sensors and more affordable active shielding technologies, the present demonstrates that several novel systems have been developed and tested in multicenter clinical trials adopting both shielded and unshielded MCG built-in hospital environments. The future of MCG will mostly be dependent on the results from the ongoing progress in novel sensor technology, which is relatively soon foreseen to provide multiple alternatives for the construction of more compact, affordable, portable, and even wearable devices for unshielded MCG inside hospital environments and perhaps also for ambulatory patients.

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Section: Unshielded Mcg: the Pastmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical magnetocardiography: the unshielded bet—past, present, and future

Brisinda,

Fenici,

Fenici

2023

Front. Cardiovasc. Med.

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“…На такій стадії ці хвороби неможливо діагностувати іншими засобами. Розроблено електрокардіографічно-фотометричний програмно-апаратний комплекс, який вирізняється портативністю, поєднує глибину аналізу з наочністю представлення результатів, включає алгоритми діагностики 4-го покоління та повністю автоматизує діагностичний висновок [19].…”

Section: статті та оглядиunclassified

Mathematical modeling: from MESM to exaflops

Сергиенко¹,

Химич²

2019

Visn. Nac. Akad. Nauk Ukr.

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“…The analysis of the MCG could be described at successive levels of computerized MCG signal processing [1]. The most advanced level of analysis is based on so-called inverse solution, i.e.…”

Section: Introductionmentioning

confidence: 99%

Value of Topology Approach to Diagnose of CAD Based on Magnetocardiographic Current Distribution Maps in Difficult-to-Diagnose Patients

Chaikovsky¹,

Stadnyuk²,

Verba³

et al. 2016

WJCD

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Objective: The purpose of this work is to examine the usefulness of the topological approach for analysis of current density maps during ST-T interval in detection of coronary artery disease (CAD) in patients with proved CAD but normal results of routine tests. Materials and Methods: The patient group included 123 patients. Coronary angiography was done due to chest pain. The control group consisted of 124 healthy volunteers. The MCG test was done by 4-channels MCG system installed at unshielded setting. An integral topological index Kideal, consisting of 4 parameters, has been counted. Results and Conclusions: It is shown that K ideal was higher in patient group compared to control one. Sensitivity was 87%, and specificity was 64%. The topological analysis of MCG current density maps is a valuable tool in noninvasive detection of CAD in difficult-to-diagnose patients with uninformative results of routine tests.

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Magnetocardiography in Unshielded Setting: Heart Electrical Image Based on 2-D and 3-D Data in Comparison with Perfusion Image Based on PET Results – Clinical Cases

Cited by 4 publications

References 5 publications

Clinical magnetocardiography: the unshielded bet—past, present, and future

Clinical magnetocardiography: the unshielded bet—past, present, and future

Mathematical modeling: from MESM to exaflops

Value of Topology Approach to Diagnose of CAD Based on Magnetocardiographic Current Distribution Maps in Difficult-to-Diagnose Patients

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