Magnetoliposomes: opportunities and challenges

Monnier, Christophe; Burnand, David; Rothen‐Rutishauser, Barbara; Lattuada, Marco; Petri‐Fink, Alke

doi:10.1515/ejnm-2014-0042

Cited by 61 publications

(40 citation statements)

References 34 publications

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“…MLs were formed by 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) embedded with two types of NPs: citrate-coated Fe 3 O 4 NPs and oleic acid-coated g-Fe 2 O 3 NPs. A consistent number of reports (recently summarized in a comprehensive review 34 ) have demonstrated that the citrate coating allows for the encapsulation of magnetic NPs within the liposome lumen, while the oleic acid coating takes to their embedding at the level of the lipid bilayer. MLs were dispersed in bovine serum at different protein concentrations (10% and 55% v/v related to in vitro and in vivo protein concentrations in the biological environment) and the release was evaluated after exposure to a 5.7 kHz alternating magnetic field.…”

Section: Cobalt Ferrite (Cofe 2 O 4 )mentioning

confidence: 92%

Magnetic field responsive drug release from magnetoliposomes in biological fluids

et al. 2016

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The final fate of nano-scaled drug delivery systems into the body is highly affected by their interaction with proteins in biological fluids (serum, plasma, etc.). Nanocarriers dispersed in biological fluids bear a protein ''corona'' that covers their surface. Thus, it is extremely important to evaluate the drug release efficiency also in the biological environment where protein-nanocarrier complexes are formed. The purpose of this work is to determine how drug release from lipid vesicle carriers is influenced by the interaction with serum proteins, highlighting the importance to test the effectiveness of such systems in the biological milieu. In particular, this paper describes the magnetically triggered release behaviour of magnetoliposomes (MLs) dispersed both in aqueous physiological buffer and in bovine serum at two different concentrations (10% and 55% v/v) upon exposure to a low-frequency alternating magnetic field (LF-AMF). We studied the release from MLs loaded with two types of magnetic nanoparticles (MNPs): citrate coated Fe 3 O 4 and oleic acid coated g-Fe 2 O 3 . The permeability in the above-mentioned fluids was evaluated in terms of the fluorescence self-quenching of carboxyfluorescein (CF) entrapped inside the liposome aqueous pool. The results showed a strong reduction of the release in biological fluids, in particular at high serum concentration. We related this decrease to the formation of protein-liposome complexes that, under LF-AMF exposure, are subjected to destabilization and tend to form aggregates.Our results clearly highlight the importance of testing the release efficiency of self-assembled drug delivery systems in biological fluids, in order to understand their behaviour in the presence of proteins and biomolecules.

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Section: Cobalt Ferrite (Cofe 2 O 4 )mentioning

confidence: 92%

Magnetic field responsive drug release from magnetoliposomes in biological fluids

et al. 2016

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“…showed that the monoolein cubic phase with MNPs subjected to AMF for 10 minutes indicate Pn3m to HII phase transition. [40] Other works [28,30,32,41,42] rely on the so-called magnetothermal effect observed in an alternating magnetic field. This effect reveals itself as temperature rises, transferring heat to the immediate vicinity when the magnetic nanoparticles are exposed to the alternating magnetic field of sufficiently high frequency (typically from several kHz to hundreds of kHz) due to the Néel and Brownian relaxation [43].…”

Section: Low-frequency Alternatingmentioning

confidence: 99%

“…[24] Magnetic nanoparticles and ions are currently of great interest in research related to medical applications [25] and are used as contrast agents for theranostics in medical imaging applications [26]. Few reported studies examined the effect of the addition of nanoparticles to liquid crystalline hexagonal phase [27], liposomes [28,29] and cubosomes [30][31][32] creating a magnetic responsive system.…”

Section: Introductionmentioning

confidence: 99%

Hybrid delivery systems for methotrexate-lipidic liquid crystalline cubic phases and cubosomes with magnetic nanoparticles

M¹,

Krysiński²,

Bilewicz³

2019

Preprint

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The release profiles of methotrexate, an anticancer drug, from the monoolein liquid crystalline cubic phases were studied. The cubic phases were used either in the form of a lipidic film deposited onto a glassy carbon electrode surface or in the dispersed form of magnetocubosomes, which are considered a prospective hybrid drug delivery system. Commonly, cubosomes or liposomes are employed, but not in the case of toxic methotrexate, known to block receptors responsible for folate transport into the cells. The release profiles of the drug from the lipidic films were monitored electrochemically and described using the Higuchi model. They were also modified via changes in temperature; the release was faster, although deviating from the model when the temperature was increased. Magnetocubosomes - cubic phase nanoparticles containing hydrophobic magnetic nanoparticles placed in an alternating magnetic field of low frequency and amplitude, stimulated drug release from the suspension, which was monitored spectroscopically. These new biocompatible hybrid materials are very promising, allowing to control the release of the drug at the appropriate sites, but do require further investigations into their in vitro cytotoxicity and in vivo biodistribution.

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“…However, mesoporous silica materials are gradually receiving interest due to their unique properties, such as well-established drug delivery properties (Vallet-Regi et al, 2007) and versatility for creating high-performing hybrid materials. Besides mesoporous silica, other multifunctional devices based on various nano-platforms were discovered (Soenen et al, 2011;Monnier et al, 2014;Chauhan et al, 2018;Hameed et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Silica Nanoparticles for Bio-Applications

Niculescu

2020

Front. Mater.

152

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Mesoporous materials with high specific surface, pores volume and unique pore size were recently intensively studied as bio-materials, such as carriers for controlled bio-active principles delivery. Mesoporous silica materials exhibit greater capacity for drugs loading and insure a controlled bio-active compound release if they are functionalized, in comparison with amorphous colloidal silica. Mesoporous silica nanomaterials have lately earned increasing interest also due to their substantial capability to be used in tumors treatment and imaging. Recently, functionalized mesoporous silica materials known a rapid development in imagistic and curative applications. This review summarizes the recent advancement in the obtaining and biological properties of mesoporous silica nanomaterials, emphasizing the synthesis methods and drug delivery application. Commonly used synthetic strategies are discussed, followed by a systematic review of applicability in optical and MRI imaging.

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Magnetoliposomes: opportunities and challenges

Cited by 61 publications

References 34 publications

Magnetic field responsive drug release from magnetoliposomes in biological fluids

Magnetic field responsive drug release from magnetoliposomes in biological fluids

Hybrid delivery systems for methotrexate-lipidic liquid crystalline cubic phases and cubosomes with magnetic nanoparticles

Mesoporous Silica Nanoparticles for Bio-Applications

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