Magnifying i-scan Imaging for Endoscopic Diagnosis of Helicobacter pylori Infection: A Prospective Study

Abstract

<jats:title>Abstract</jats:title><jats:p> Background DEFINA (EPK 3000) plus (with i-scan) is a digital chromoendoscopy. It uses surface/tone/contrast enhancement for detection, demarcation, and characterization of lesions. The aim of this study was to compare the usefulness of i-scan and conventional magnification white light endoscopy (M-WLE) for diagnosing Helicobacter pylori (Hp) infection in stomach.</jats:p><jats:p> Patients and Methods Subjects undergoing evaluation for functional dyspepsia were prospectively enrolled at Ramaiah Medical College and Hospitals, Bangalore from November 2018 to February 2019. In total, 68 participants underwent gastroscopy with standard M-WLE followed by i-scan. Two biopsies from greater curve at 3 cm from the angulus were collected for histology. Successful diagnosis of Hp using imaging modality with M-WLE and i-scan were compared with histology.</jats:p><jats:p> Results A total of 68 (36 men and 32 women) patients with a mean age of 47 ± 13 years (range 18–75 years) were enrolled in our study. The prevalence of Hp on the biopsies was 41%; 64% of the patients used proton pump inhibitors, 20% were current smokers; 25% of the patients were consuming alcohol. The sensitivity: 96.4%; specificity: 95%; accuracy: 95.5% of i-scan in diagnosis of Hp gastritis is better than the sensitivity: 50%; specificity: 50%; accuracy: 50% with M-WLE.</jats:p><jats:p> Conclusion In conclusion, the diagnostic ability of i-scan (95%) for predicting Hp status is acceptable as compared with M-WLE (50%) for accurate diagnosis. The results suggest that i-scan improves endoscopic diagnostic accuracy of Hp infection compared with M-WLE.</jats:p>

Expanding Role of Image-Enhanced Gastrointestinal Endoscopy in Clinical Practice

“…This issue of the journal contains two original research articles and one case report on clinical applications of IEE. [4][5][6] They highlight the potential of IEE in identifying lesions in different parts of the GI tract.…”

“…4,7 Taken together, these findings have shown a good accuracy in predicting H pylori infection. 10 The study by Balekudru et al 5 investigates the utility of IEE (i-scan) in detecting features associated with H pylori infection . In this prospective study, 68 patients with functional dyspepsia underwent magnification white light endoscopy (M-WLE), followed by i-scan.…”