Main bronchus occlusion for treatment of congenital diaphragmatic hernia in fetal lambs

Biard, Jean–Marc; Schwarz, Uwe; Davey, Mary‐Ann; Danzer, Enrico; Johnson, Mark P.; Flake, Alan W.; Adzick, Scott; Hedrick, Holly L.

doi:10.1016/j.jpedsurg.2007.09.071

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…As has been previously reported, left lungs were more impacted, and hence less functional, than right lungs in the left CDH setting. 40,41 Similarly, the metabolic dormancy was, as expected, more pronounced in the left than the right lungs in the rabbit left CDH model (Figs. 5 and 6).…”

Section: Discussionsupporting

confidence: 79%

Heterogeneous Response in Rabbit Fetal Diaphragmatic Hernia Lungs After Tracheal Occlusion

Dobrinskikh

Al-Juboori

Oria

et al. 2020

Journal of Surgical Research

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Section: Discussionsupporting

confidence: 79%

Heterogeneous Response in Rabbit Fetal Diaphragmatic Hernia Lungs After Tracheal Occlusion

Dobrinskikh

Al-Juboori

Oria

et al. 2020

Journal of Surgical Research

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“…Biard et al conducted experiments on sheep, in which 1 bronchus was selectively closed on the side where the diaphragmatic hernia appeared. Nevertheless, experimental results do not confirm the efficacy of the method mentioned above in restoration of the lungs’ normal expanding potential [14]. …”

Section: Congenital Diaphragmatic Herniamentioning

confidence: 99%

In utero surgery – current state of the art – part II

Wójcicki

Drozdowski²

2011

Med Sci Monit

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SummaryBackgroundFetal surgery, also referred to as in utero, prenatal or intrauterine surgery, consists of treatment of congenital malformations during the fetal period. The idea of treating malformations diagnosed in the course of intrauterine life dates back to 1963, when Lilly performed the first blood transfusion in a fetus. Since then it has been introduced as a treatment option in a series of lethal malformations. Efforts are being made to treat nonlethal malformations by means of fetal surgery.Material/MethodsA comprehensive search of the literature using MEDLINE and PubMed between 1925 and February 2009 was performed. Search terms for MEDLINE and PubMed were: fetal surgery, foetal surgery, in utero surgery, prenatal surgery, and in utero treatment. In addition, information was obtained at Web sites of the International Medicine and Surgery Society and the University of California Fetal Treatment Centre.ResultsAuthors’ attention focused on the survey of indications to intrauterine operations. We outline potential directions of its development, quoting the groundwork of the most experienced researchers and clinicians. Moreover, owing to the authors’ interest in plastic surgery, some remarks on the role of intrauterine medicine and surgery in this branch of medicine are made.ConclusionsIn utero surgery may be regarded as an efficient tool of preventive medicine. It offers some advantages that no other branch of medicine may offer. However, its implementation is more troublesome than in the past, therefore only selected cases may benefit from its advantages. Nevertheless, current tendencies are to include, after thorough evaluation of benefit-risk ratio, some new indications for fetal surgery.

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“…Fetal PLUG is a video assisted fetal endoscopy, which avoids the need for hysterotomy. 10,13 Prognosis Despite many advances in the treatment of CDH including ECMO, gentle ventilation, nitric oxide, and fetal therapy the overall survival for CDH still remains approximately 65%. Infants with severe CDH require ECMO, with survival rate ranging from 50% to 65%.…”

Section: Antenatal Managementmentioning

confidence: 99%

Perinatal management of common neonatal thoracic lesions

Kumar

2008

Indian J Pediatr

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Esophageal atresia, congenital diaphragmatic hernia, bronchopulmonary malformations and cystic lung diseases are the common neonatal thoracic surgical lesions encountered in practice. The availability of antenatal ultrasonography has lead to these lesions being detected before birth. Antenatal diagnosis can be made with a fair degree of accuracy in tertiary fetal medicine centres. Antenatal intervention is limited in a very few centres in the western world and not being done in India at present. The outcome of these babies with antenatal diagnosis of thoracic lesions has changed in the last decade. Earlier intervention is now possible in cystic lung disease before infectious complication has set in. All these lesions are managed exclusively in well developed neonatal surgery units with excellent outcome in the western world. The present study reviews the antenatal detection, clinical presentation, interventional/surgical procedures [antenatally and postnatally] and outcome of these common neonatal thoracic surgical lesions.

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Main bronchus occlusion for treatment of congenital diaphragmatic hernia in fetal lambs

Cited by 4 publications

References 37 publications

Heterogeneous Response in Rabbit Fetal Diaphragmatic Hernia Lungs After Tracheal Occlusion

Heterogeneous Response in Rabbit Fetal Diaphragmatic Hernia Lungs After Tracheal Occlusion

In utero surgery – current state of the art – part II

Perinatal management of common neonatal thoracic lesions

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