Major Histocompatibility Complex Class-I-Interacting Natural Killer Cell Receptors of Nonhuman Primates

Walter, Lutz

doi:10.1159/000323932

Cited by 9 publications

(4 citation statements)

References 76 publications

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“…Recent studies have suggested that adopted transfer of NK cells may be a promising therapeutic approach for cancer patients ( 4 – 7 ). The phenotypic and functional characteristics of NK cells have been documented in various species, including mice, rat, pigs, cows, and humans ( 8 – 11 ). Although the total population of human and mouse NK cells is phenotypically and functionally heterogeneous ( 12 , 13 ), expression of specific surface molecules, such as CD56 and CD16 on human cells, and NK1.1 and NKp46 on mouse NK cells, allows the identification of NK cells.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Phenotypic and Functional Characteristics Between Canine Non-B, Non-T Natural Killer Lymphocytes and CD3+CD5dimCD21− Cytotoxic Large Granular Lymphocytes

et al. 2018

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Natural killer (NK) cells play a pivotal role in the immune response against infections and malignant transformation, and adopted transfer of NK cells is thought to be a promising therapeutic approach for cancer patients. Previous reports describing the phenotypic features of canine NK cells have produced inconsistent results. Canine NK cells are still defined as non-B and non-T (CD3−CD21−) large granular lymphocytes. However, a few reports have demonstrated that canine NK cells share the phenotypic characteristics of T lymphocytes, and that CD3+CD5dimCD21− lymphocytes are putative canine NK cells. Based on our previous reports, we hypothesized that phenotypic modulation could occur between these two populations during activation. In this study, we investigated the phenotypic and functional differences between CD3+CD5dimCD21− (cytotoxic large granular lymphocytes) and CD3−CD5−CD21− NK lymphocytes before and after culture of peripheral blood mononuclear cells isolated from normal dogs. The results of this study show that CD3+CD5dimCD21− lymphocytes can be differentiated into non-B, non-T NK (CD3−CD5−CD21−TCRαβ−TCRγδ−GranzymeB+) lymphocytes through phenotypic modulation in response to cytokine stimulation. In vitro studies of purified CD3+CD5dimCD21− cells showed that CD3−CD5−CD21− cells are derived from CD3+CD5dimCD21− cells through phenotypic modulation. CD3+CD5dimCD21− cells share more NK cell functional characteristics compared with CD3−CD5−CD21− cells, including the expression of T-box transcription factors (Eomes, T-bet), the production of granzyme B and interferon-γ, and the expression of NK cell-related molecular receptors such as NKG2D and NKp30. In conclusion, the results of this study suggest that CD3+CD5dimCD21− and CD3−CD5−CD21− cells both contain a subset of putative NK cells, and the difference between the two populations may be due to the degree of maturation.

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Section: Introductionmentioning

confidence: 99%

Comparison of Phenotypic and Functional Characteristics Between Canine Non-B, Non-T Natural Killer Lymphocytes and CD3+CD5dimCD21− Cytotoxic Large Granular Lymphocytes

et al. 2018

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“…Killer cell immunoglobulin-like receptors (KIR) are crucial regulators of NK cell activity and exhibit considerable allelic polymorphism and copy-number variations in humans and higher primates ( 5 , 6 ). Epidemiological studies of human immunodeficiency virus 1 (HIV-1) infection indicate that a combination of HLA-Bw4-80I with either KIR3DL1 or KIR3DS1 is associated with delayed progression to AIDS ( 3 , 7 – 9 ).…”

Section: Introductionmentioning

confidence: 99%

Progression to AIDS in SIV-Infected Rhesus Macaques is Associated with Distinct KIR and MHC class I Polymorphisms and NK Cell Dysfunction

et al. 2014

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Killer cell immunoglobulin-like receptors (KIR) regulate the activity of natural killer (NK) cells and have been shown to be associated with susceptibility to a number of human infectious diseases. Here, we analyzed NK cell function and genetic associations in a cohort of 52 rhesus macaques experimentally infected with SIVmac and subsequently stratified into high viral load (HVL) and low viral load (LVL) plasma viral loads at set point. This stratification coincided with fast (HVL) and slow (LVL) disease progression indicated by the disease course and critical clinical parameters including CD4+ T cell counts. HVL animals revealed sustained proliferation of NK cells but distinct loss of peripheral blood NK cell numbers and lytic function. Genetic analyses revealed that KIR genes 3DL05, 3DS05, and 3DL10 as well as 3DSW08, 3DLW03, and 3DSW09 are correlated, most likely due to underlying haplotypes. SIV-infection outcome associated with presence of transcripts for two inhibitory KIR genes (KIR3DL02, KIR3DL10) and three activating KIR genes (KIR3DSW08, KIR3DS02, KIR3DS05). Presence of KIR3DL02 and KIR3DSW08 was associated with LVL outcome, whereas presence of KIR3DS02 was associated with HVL outcome. Furthermore, we identified epistasis between KIR and MHC class I alleles as the transcript presence of the correlated genes KIR3DL05, KIR3DS05, and KIR3DL10 increased HVL risk when Mamu-B*012 transcripts were also present or when Mamu-A1*001 transcripts were absent. These genetic associations were mirrored by changes in the numbers, the level of proliferation, and lytic capabilities of NK cells as well as overall survival time and gastro-intestinal tissue viral load.

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“…Larger consortia that compile large -omics datasets for marmosets are being built [96,97]. For instance, functional genomics data from marmoset brain tissues have been collected and incorporated into the NIH Brain initiative [98]. This is of particular relevance as the common marmoset has been identified as an important model organism for neuroscience research that can bridge the gap between mice and humans [96,99].…”

Section: Callithrix Functional Genomics and Epigenomicsmentioning

confidence: 99%

An Introduction to the Callithrix Genus and Overview of Recent Advances in Marmoset Research

Malukiewicz¹,

Boere²,

Oliveira³

et al. 2020

Preprint

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We provide here a current overview of marmoset (Callithrix) evolution, hybridization, species biology, basic/biomedical research, and conservation initiatives. Composed of two subgroups, the aurita group (C. aurita and C. flaviceps) and the jacchus group (C. geoffroyi, C. jacchus, C. kuhlii and C. penicillata), this relatively young primate radiation is endemic to the Brazilian Cerrado, Caatinga, and Atlantic Forest biomes. Significant impacts on Callithrix within these biomes resulting from anthropogenic activity include: (1) population declines, particularly for the aurita group; (2) widespread geographic displacement, biological invasions, and range expansions of C. jacchus and C. penicillata; (3) anthropogenic hybridization; and (4) epizootic Yellow Fever and Zika viral outbreaks. A number of Brazilian legal and conservation initiatives are now in place to protect the threatened aurita group and increase research into them. Due to their small size and fast life history, marmosets are prized biomedical models. As a result, there are increasingly sophisticated genomic Callithrix resources available and burgeoning marmoset functional, immuno-, and epi- genomic research. In both the laboratory and the wild, marmosets have given us insight into cognition, social group dynamics, human disease, and pregnancy. Callithrix jacchus and C. penicillata are emerging Neotropical primate models for arbovirus disease, including Dengue and Zika. Wild marmoset populations are helping us understand sylvatic transmission and human spillover of Zika and Yellow Fever viruses. All of these factors are positioning marmosets as preeminent models to facilitate understanding of facets of evolution, hybridization, conservation, human disease, and emerging infectious diseases.

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Major Histocompatibility Complex Class-I-Interacting Natural Killer Cell Receptors of Nonhuman Primates

Cited by 9 publications

References 76 publications

Comparison of Phenotypic and Functional Characteristics Between Canine Non-B, Non-T Natural Killer Lymphocytes and CD3+CD5dimCD21− Cytotoxic Large Granular Lymphocytes

Comparison of Phenotypic and Functional Characteristics Between Canine Non-B, Non-T Natural Killer Lymphocytes and CD3+CD5dimCD21− Cytotoxic Large Granular Lymphocytes

Progression to AIDS in SIV-Infected Rhesus Macaques is Associated with Distinct KIR and MHC class I Polymorphisms and NK Cell Dysfunction

An Introduction to the Callithrix Genus and Overview of Recent Advances in Marmoset Research

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