Major Undesirable Side-Effects Resulting From Prednisolone and Prednisone

Bollet, Alfred Jay; Black, Roger L.; Bunim, Joseph J.

doi:10.1001/jama.1955.02960060017005

Cited by 136 publications

(45 citation statements)

References 8 publications

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“…An intestinal stricture that is largely infl ammatory often responds quickly to high-dose steroid therapy or therapy with potent anti-tumor necrosis factor a agents. This may relieve the intestinal obstruction but exposes the patient to the numerous potential side effects of medical therapy, including the deleterious effects of steroids on the growth and development of children (3)(4)(5)(6)(7). An intestinal stricture that is primarily fi brotic in nature will not respond to current medical treatment; however, it requires surgical resection ( 8 ).…”

Section: Animal Modelmentioning

confidence: 99%

Magnetization Transfer Helps Detect Intestinal Fibrosis in an Animal Model of Crohn Disease

Adler¹,

Swanson²,

et al. 2011

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Section: Animal Modelmentioning

confidence: 99%

Magnetization Transfer Helps Detect Intestinal Fibrosis in an Animal Model of Crohn Disease

Adler¹,

Swanson²,

et al. 2011

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“…Although several therapies are available for the treatment of asthma, none appear to be as effective as corticosteroids (8). However, the use of corticosteroids may promote undesirable side effects, and many patients are refractory to this treatment (9,10). Because the incidence of allergic asthma is increasing in the Western world (11) and current therapies are not totally effective (12), the development of novel treatments for the disease is necessary.…”

mentioning

confidence: 99%

Airway Epithelial Indoleamine 2,3-Dioxygenase Inhibits CD4⁺T Cells duringAspergillus fumigatusAntigen Exposure

Paveglio¹,

Allard²,

Hodgkins³

et al. 2011

Am J Respir Cell Mol Biol

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Indoleamine 2,3-dioxygenase (IDO) suppresses the functions of CD4 1 T cells through its ability to metabolize the essential amino acid tryptophan. Although the activity of IDO is required for the immunosuppression of allergic airway disease by the Toll-LikeReceptor 9 (TLR9) agonist, oligonucleotides comprised of cytosine and guanine nucleotides linked by phosphodiester bonds (CpG) DNA, it is unclear whether IDO expression by resident lung epithelial cells is sufficient to elicit these effects. Therefore, we created a transgenic mouse inducibly overexpressing IDO within nonciliated airway epithelial cells. Upon inhalation of formalin-fixed Aspergillus fumigatus hyphal antigens, the overexpression of IDO from airway epithelial cells of these mice reduced the number of CD4 1 T cells within the inflamed lung and impaired the capacity of antigen-specific splenic CD4 1 effector T cells to secrete the cytokines IL-4, IL-5, IL-13, and IFN-g. Despite these effects, allergic airway disease pathology was largely unaffected in mice expressing IDO in airway epithelium. In support of the concept that dendritic cells are the major cell type contributing to the IDO-inducing effects of CpG DNA, mice expressing TLR9 only in the airway epithelium did not augment IDO expression subsequent to the administration of CpG DNA. Furthermore, the systemic depletion of CD11c 1 cells rendered mice incapable of CpG DNA-induced IDO expression. Our results demonstrate that an overexpression of IDO within the airway epithelium represents a novel mechanism by which the number of CD4 1 T cells recruited to the lung and their capacity to produce cytokines can be diminished in a model of allergic airway disease, and these results also highlight the critical role of dendritic cells in the antiasthmatic effects of IDO induction by CpG DNA.

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“…The side effects of prolonged use of systemic corticosteroids are numerous, well-established, and may be serious [42]. Short courses of corticosteroids, which usually are prescribed for CH, typically are well tolerated and the reviewed trial reports are consistent with this conclusion.…”

Section: The Safety and Tolerability Of Corticosteroids In Cluster Hementioning

confidence: 62%

Corticosteroid treatment in cluster headache: Evidence, rationale, and practice

Shapiro

2005

Current Science Inc

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The use of corticosteroids in the treatment of cluster headache (CH) is commonplace and has been a mainstay of clinical practice for this indication for 50 years. The published evidence supporting this practice is weak, with no methodologically rigorous or large-scale controlled trials executed. Nonetheless, the clinical experiences of practitioners and the conclusion of investigators provide a clear signal of benefit from corticosteroid use in CH. The pathophysiologic explanation for this beneficial effect is unknown, but corticosteroid influences on inflammatory, hypothalamic-pituitary-adrenal, histaminergic, and opioid systems have been proposed. Best-practice parameters are unclear, but the professional consensus is that corticosteroids generally are effective for arresting CH attacks, only if administered in relatively high doses, and that safety concerns warrant courses of 4 weeks or less. Concomitant use of other prophylactic agents for CH in addition to corticosteroids usually is advisable because attacks often recur when the corticosteroid dose is tapered.

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Major Undesirable Side-Effects Resulting From Prednisolone and Prednisone

Cited by 136 publications

References 8 publications

Magnetization Transfer Helps Detect Intestinal Fibrosis in an Animal Model of Crohn Disease

Magnetization Transfer Helps Detect Intestinal Fibrosis in an Animal Model of Crohn Disease

Airway Epithelial Indoleamine 2,3-Dioxygenase Inhibits CD4⁺T Cells duringAspergillus fumigatusAntigen Exposure

Corticosteroid treatment in cluster headache: Evidence, rationale, and practice

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Major Undesirable Side-Effects Resulting From Prednisolone and Prednisone

Cited by 136 publications

References 8 publications

Magnetization Transfer Helps Detect Intestinal Fibrosis in an Animal Model of Crohn Disease

Magnetization Transfer Helps Detect Intestinal Fibrosis in an Animal Model of Crohn Disease

Airway Epithelial Indoleamine 2,3-Dioxygenase Inhibits CD4+T Cells duringAspergillus fumigatusAntigen Exposure

Corticosteroid treatment in cluster headache: Evidence, rationale, and practice

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Airway Epithelial Indoleamine 2,3-Dioxygenase Inhibits CD4⁺T Cells duringAspergillus fumigatusAntigen Exposure