Making Room in the Parking Lot for More Cars - How Changes to Autologous Collection Targets for Patients with Multiple Myeloma Optimized Resource Utilization in the Apheresis Collection Center and Cell Storage Facility at Dana-Farber Cancer Institute

Abstract

The primary cause of death was relapse in both groups, whereas 5 (23.8%) and 11 (12.8%) patients died of TRM in TBI and non-TBI groups (p>0.1). The OS at 1 and 3 years were slightly higher in non-TBI group (Figure 1a). When analyzed according to the TBI doses, median OS is similar between two groups (Figure 1b). Discussion: Irradiation is known to inhibit lymphocyte activity and consequently to reduce the incidence of GVHD in experimental models for allo-HSCT. In our study, acute and chronic GVHD incidence was similar in both groups but lower survival rate was seen in TBI group (p>0.1). Larger and prospective studies are warranted.