Malabsorption syndrome after gastroenteritis in children, optimization of therapy

Abstract

The period of convalescence after gastroenteritis in children in modern circumstances is often complicated by the development of post-infectious malabsorption syndrome, in the pathogenesis of which the development of bacterial overgrowth syndrome (BOS) is important. At present, the issue of treatment of BOS in children has not been finally resolved. The use of modern enterosorbents can be considered a good alternative to antibacterial therapy of BOS. Purpose - to evaluate the effectiveness of the inclusion of highly dispersed silicon dioxide in the complex therapy of malabsorption syndrome after gastroenteritis in children. Materials and methods. 30 children aged from 3 to 12 years with malabsorption syndrome after gastroenteritis during the last 6 months were under observation. Patients on the background of standard treatment were prescribed highly dispersed silicon dioxide for 3-5 days. In dynamics, subjective complaints of patients and/or their parents were assessed, clinical symptoms and results of coprological and bacteriological examination of feces were evaluated. Results. While including highly dispersed silicon dioxide into the treatment, in the vast majority of patients (according to individual indicators, 75-85%), a rapid normalization of the frequency and consistency of stools, a decrease in the frequency and severity of flatulence, improvement of digestion and assimilation of nutrients according to the indicators of a coprological study, which had a positive effect on the general condition, were noted. The results of the bacteriological examination of feces in dynamics showed a significant decrease in the frequency of detection and the number of opportunistic bacteria, fungal flora and tendency to increase the number of representatives of the indigenous microflora. Conclusions. The results of the work make it possible to recommend the inclusion of enterosorption with the usage of highly dispersed silicon dioxide in the complex of restorative therapy in children with malabsorption syndrome after gastroenteritis. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the institution mentioned in the work. The informed consent of the children’s parents was obtained for the conducting the studies. No conflict of interests was declared by the authors.