Malaria in Assam: A challenge

Pardal, Maninder Pal Singh; Bhalwar, Rajvir; Mehta, Vijay; Mahendraker, Ajay; Mehta, A. K.

doi:10.4103/0970-0218.51225

Cited by 9 publications

(3 citation statements)

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“…Currently changing trends with increase in the incidence and mortality related to P. falciparum malaria are observed. [ 1 ] P. falciparum malaria affects all age groups with multiple systemic complications which vary in different age groups. Hepatopathy is one of the complications of P. falciparum malaria.…”

Section: Introductionmentioning

confidence: 99%

Malarial hepatopathy and its outcome in India

2012

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Background:Jaundice in Plasmodium falciparum malaria is multifactorial and its incidence varies in different regions. It is important to assess the incidence and factors associated with malarial hepatopathy as well as its complications to understand the pattern of disease presentation in order to undertake appropriate interventional measures. There is a paucity of data with regard to malarial hepatopathy and its outcome at the global level.Aim:The study was conducted to assess the pattern, spectrum of biochemical parameters and complications of hepatopathy related to P. falciparum malaria.Materials and Methods:A descriptive study was conducted in a tertiary care hospital attached to a government medical institution in Assam, India. Demographic details of the hundred patients with P. falciparum malaria, their clinical and biochemical parameters, complications and outcome were collected using a prestructured proforma. Data was compared using proportion and Chi Square test.Results:The proportion of those with malarial hepatopathy was 38% and the incidence was more in males and younger age group. The degree of hyperbilirubinemia, complications that include renal failure, shock, acute respiratory distress syndrome, hypoglycemia and mortality were significantly more among patients with hepatopathy (P<0.05).Conclusion:Malarial hepatopathy is associated with a higher incidence of complications like renal failure, shock, acute respiratory distress syndrome and hypoglycemia. Further studies are required to elucidate the factors associated with malarial hepatopathy and to prevent the complications and mortality.

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Section: Introductionmentioning

confidence: 99%

Malarial hepatopathy and its outcome in India

2012

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“…[ 6 ] The deaths occurred mostly in the rainy season (April-September) and among all age groups of both sexes. [ 7 ]…”

Section: Methodsmentioning

confidence: 99%

Role of serum lactate and malarial retinopathy in prognosis and outcome of falciparum and vivax cerebral Malaria: A prospective cohort study in adult assamese tribes

Chaudhari

Uttarwar

Tambe

et al. 2016

J Global Infect Dis

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Introduction:There is no comprehensive data or studies relating to clinical presentation and prognosis of cerebral malaria (CM) in the tribal settlements of Assam. High rates of transmission and deaths from complicated malaria guided us to conduct a prospective observational cohort study to evaluate the factors associated with poor outcome and prognosis in patients of CM.Materials and Methods:We admitted 112 patients to the Bandarpara and Damodarpur Tribal Health Centers (THCs) between 2011 and 2013 with a strict diagnosis of CM. We assessed the role of clinical, fundoscopy and laboratory findings (mainly lactic acid) in the immediate outcome in terms of death and recovery, duration of hospitalization, neurocognitive impairment, cranial nerve palsies and focal neurological deficit.Results:The case fatality rate of CM was 33.03% and the prevalence of residual neurological sequelae at discharge was 16.07%. These are significantly higher than the previous studies. The mortality rate and neurological complications rate in patients with retinal whitening was 38.46% and 23.07%, with vessel changes was 25% and 18.75%, with retinal hemorrhage was 55.55% and 11.11% and with hyperlactatemia was 53.85% and 18.46%, respectively. Three patients of papilledema alone died.Conclusion:Our study suggests a strong correlation between hyperlactatemia, retinal changes (whitening, vessel changes and hemorrhage) and depth and duration of coma with longer duration of hospitalization, increased mortality, neurological sequelae and death. Plasmodium vivax mono-infection as a cause of CM has been confirmed. Prognostic evaluation of CM is useful for judicious allocation of resources in the THC.

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“…1 and 2; Table 1-6). Palat et al, 2013), (Patil and Kumar, 2011), (Pardal et al, 2009), (Anirudh et al, 2013), (Singh et al, 2009), (Singh et al, 2015).…”

Section: Plasmodiummentioning

confidence: 99%