Malassezia-Can it be ignored?

Thayikkannu, Ambujavalli Balakrishnan; Kindo, Anupma Jyoti; Veeraraghavan, Mahalakshmi

doi:10.4103/0019-5154.160475

Cited by 34 publications

(19 citation statements)

References 64 publications

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“…The current study revealed that the age group (15-22) years was frequently exposed to Malassezia infection, followed by (23-30) years age group.The age group (39-42) years was the minimally exposed to infection compared with other groups. This result come in accordance with that reported in India and Iraq by [17], [23], [24], [25], [26], [27], [28]. M. furfur was the predominant species recovered from PV cases while M. pachydermatis was the least once.…”

Section: Discussionsupporting

confidence: 92%

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Phenotypic Identification and Molecular Characterization of Malassezia Spp. Isolated from Pityriasis Versicolor Patients with Special Emphasis to Risk Factors in Diyala Province, Iraq

Awad¹,

Al-Ezzy²,

Jameel³

2019

Open Access Maced J Med Sci

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AIM: The main objective is isolation and molecular characterisation of Malassezia spp. from pityriasis versicolor (PV) patients with special emphasis to risk factors in Diyala province, Iraq. METHODS: Fifty patients (32 males and 18 females) presented with PV, the age ranged (15-45) years were included. Direct wet mount using KOH 10%, culture of skin scraping and PCR were used for confirmatory diagnosis. RESULTS: Malassezia spp. was isolated from (54%) of skin scraping; M. furfur (32%); M. pachydermatis (8%) and M. globosa (14%). The age group (15-22) years were frequently exposed to Malassezia infection. A significant inverse correlation was reported between age and exposure to Malassezia spp. Infection. Males were frequently exposed to Malassezia infection, (40%). A significant correlation was reported between gender and exposure to Malassezia spp. Infection. Females were at risk of getting Malassezia infection (2.619) time than males. Patient resident in the urban area frequently exposed to Malassezia infection, (34%). Patients resident in the rural area appears to be at risk of getting Malassezia infection (1.093) time than those in an urban area. Patient with good economic status was frequently exposed to Malassezia infection, (36%). Patients with middle economic status appear to be at risk of getting Malassezia infection (0.42) time than those with good economic status. Patients with primary education were frequently exposed to Malassezia infection, (22%). A significant correlation was reported between education level and exposure to Malassezia spp. Infection. No significant correlation was reported between economic status; type of job; source of water; contact with dogs and birds and Malassezia spp. Infection. CONCLUSION: M. furfur, M. pachydermatis and M. globosa represent the most common Malassezia spp. causing PV. Using of PCR is very critical to confirm the diagnosis of Malassezia spp. Malassezia infection inversely correlated with age and positively correlated with females gender and education. The residency in a rural area and middle economic status increase the possibility of infection. Infection was not affected by the source of water; job and contact with dogs and birds.

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Section: Discussionsupporting

confidence: 92%

“…An inverse significant correlation was reported between age and exposure to Malassezia spp . Infection, which agrees with Al-ammari from Iraq and Thayikkannu et al, from India [20], [25].…”

Section: Discussionsupporting

confidence: 84%

Phenotypic Identification and Molecular Characterization of Malassezia Spp. Isolated from Pityriasis Versicolor Patients with Special Emphasis to Risk Factors in Diyala Province, Iraq

Awad¹,

Al-Ezzy²,

Jameel³

2019

Open Access Maced J Med Sci

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“…9 However, Malassezia infections can manifest as superficial localized or can cause systemic infections in immune-compromised hosts. 10 Research suggests that immune response and inflammation show the presence of host susceptibility factors, allowing the transition of M furfur to its pathogenic form. 11…”

Section: Immunosuppresive Diseases and Pityriasis Capitismentioning

confidence: 99%

Pityriasis capitis: Causes, pathophysiology, current modalities, and future approach

Sheth

Dande

2020

J of Cosmetic Dermatology

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Background: Pityriasis capitis commonly known as dandruff is one of the most common and widely seen dermatological disease that affects majority of the world population. It is more than superficial flaking, as it leads to significant structural changes in the stratum corneum and inflammatory biomarkers. Various intrinsic and extrinsic factors, such as Malassezia yeast, host epidermal conditions, sebaceous secretion, and abnormal immune responses, are found to contribute to the pathogenesis. Regardless of wide research, detail understanding, and treatment modalities, it still remains to be a cause of concern due to its recurring nature. Aims: The objective of this study is to enhance the understanding of its wide causes, pathophysiology, current treatment, and future approach. Methods: The article also aims at evaluating various promising anti-dandruff agents that can be further researched to become the leads in anti-dandruff therapy. Results & Conclusion: The article summarizes the current knowledge on dandruff and present new facts and evidences in order to spread awareness, create potential for new herbal treatment options, and effectively control the most commercially exploited scalp disorder.

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“… 30 Therefore, individual sensitivity to the irritating FFA determines the consequent inflammatory response and may define susceptibility for seborrheic dermatitis. 31 …”

Section: Sebum Alterations In Various Skin Diseasesmentioning

confidence: 99%

Sebaceous-immunobiology is orchestrated by sebum lipids

Lovászi

Szegedi

Zouboulis

et al. 2017

Dermato-Endocrinology

111

121

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The major role of sebaceous glands in mammals is to produce sebum, which coats the epidermis and the hair providing waterproofing, thermoregulation and photoprotection. However, as the need for these functions decreased along the evolutionary changes in humans, a relevant question has been raised: are sebaceous glands and sebum the remnants of our mammalian heritage or do they have overtaken a far more complex role in human skin biology? Trying to provide answers to this question, this review introduces the evolving field of sebaceous immunobiology and puts into the focus the pathways that sebum lipids use to influence the immune milieu of the skin. By introducing possible modifiers of sebaceous lipogenesis and discussing the – human-specific – alterations in composition and amount of sebum, the attribute of sebum as a sensitive tool, which is capable of translating multiple signalling pathways into the dermal micro environment is presented. Further their interaction with macrophages and keratinocytes involves sebum lipid fractions into disease pathogenesis, which could lead – on the other side – to the development of novel sebum-based therapeutic strategies.

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Malassezia-Can it be ignored?

Cited by 34 publications

References 64 publications

Phenotypic Identification and Molecular Characterization of Malassezia Spp. Isolated from Pityriasis Versicolor Patients with Special Emphasis to Risk Factors in Diyala Province, Iraq

Phenotypic Identification and Molecular Characterization of Malassezia Spp. Isolated from Pityriasis Versicolor Patients with Special Emphasis to Risk Factors in Diyala Province, Iraq

Pityriasis capitis: Causes, pathophysiology, current modalities, and future approach

Sebaceous-immunobiology is orchestrated by sebum lipids

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