Male Genital Tract

Ulbright, Thomas M.

doi:10.1002/0470025077.chap45

Cited by 1 publication

(1 citation statement)

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“…Many prostate cancers diagnosed at an early stage are indolent but a proportion progress rapidly to become life threatening. However it is difficult to predict the progression potential of early stage cancers 3. Despite numerous investigations into the molecular mechanism of development of the disease,4 the nature and significance of genetic changes associated with prostate cancer development and progression are largely unknown.…”

Section: Introductionmentioning

confidence: 99%

The identification of chromosomal translocation, t(4;6)(q22;q15), in prostate cancer

Shan

Ambroisine

Clark

et al. 2010

Prostate Cancer Prostatic Dis

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Our previous work identified a chromosomal translocation t(4;6) in prostate cancer cell lines and primary tumors. Using probes located on 4q22 and 6q15, the breakpoints identified in LNCaP cells, we performed fluorescence in situ hybridization analysis to detect this translocation in a large series of clinical localized prostate cancer samples treated conservatively. We found that t(4;6)(q22;q15) occurred in 78 of 667 cases (11.7%). The t(4;6)(q22;q15) was not independently associated with patient outcome. However, it occurs more frequently in high clinical T stage, high tumor volume specimens and in those with high baseline PSA (P ¼ 0.001, 0.001 and 0.01, respectively). The t(4;6)(q22;q15) occurred more frequently in samples with two or more TMPRSS2:ERG fusion genes caused by internal deletion than in samples without these genomic alterations, but this correlation is not statistically significant (P ¼ 0.0628). The potential role of this translocation in the development of human prostate cancer is discussed.

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Section: Introductionmentioning

confidence: 99%