Male Pattern Baldness: classification and Incidence

Norwood, O’Tar T.

doi:10.1097/00007611-197511000-00009

Cited by 744 publications

(542 citation statements)

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“…Note that the BONN Study included only early-onset MPB cases (o40 years of age) and screened elderly controls while the RS (mainly elderly individuals: mean age 67.79 years, min 51.54, max 96.73) and ERF (mainly middle-aged: mean age 49.05 years, min 18.07, max 79.03) are population-based studies without sample selection based on MPB status. The difference in MPB prevalence observed between RS (53.3%) and ERF (44.4%) is fairly consistent with a~10% increase per decade of MPB 1 (Supplementary Table S2). …”

Section: Resultssupporting

confidence: 70%

“…18 MPB status was assessed by trained physicians according to the Norwood-Hamilton grading scale 1,19 with grades 1-12. Cases were defined as grade IV-VIII and otherwise controls.…”

Section: Rotterdam Studymentioning

confidence: 99%

“…The population shows minimal immigration and high inbreeding. Cases were defined as Norwood-Hamilton grading scale 1,19 IV-VIII at any age or grade II-III between 50 and 60 years of age or grade I before 50 years of age, and controls otherwise. The current study included 567 male ERF subjects.…”

Section: Erasmus Rucphen Family Studymentioning

confidence: 99%

“…1,3 Affected men were aged o30 years with HN grades IV-VII, or o40 years with HN grades V-VII, and were thus representative of the most severely affected 10% for the respective age classes (N = 581). The control sample comprises 270 men aged ⩾ 60 years with no signs of AGA (20% least affected individuals in the population) and 146 male controls (HN ⩽ V) that were recruited as part of the Heinz Nixdorf Recall cohort (risk factors, evaluation of coronary calcium and lifestyle) at the University of Essen.…”

Section: Bonn Studymentioning

confidence: 99%

“…1,2 MPB is a chronic problem commonly seen by dermatologists, 3 with severe psychosocial consequences 4 and limited effective therapeutic options. 5 The effectiveness of most treatments (eg, minoxidil or finasteride) relies on how early they are applied.…”

Section: Introductionmentioning

confidence: 99%

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Prediction of male-pattern baldness from genotypes

et al. 2015

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The global demand for products that effectively prevent the development of male-pattern baldness (MPB) has drastically increased. However, there is currently no established genetic model for the estimation of MPB risk. We conducted a prediction analysis using single-nucleotide polymorphisms (SNPs) identified from previous GWASs of MPB in a total of 2725 German and Dutch males. A logistic regression model considering the genotypes of 25 SNPs from 12 genomic loci demonstrates that early-onset MPB risk is predictable at an accuracy level of 0.74 when 14 SNPs were included in the model, and measured using the area under the receiver-operating characteristic curves (AUC). Considering age as an additional predictor, the model can predict normal MPB status in middle-aged and elderly individuals at a slightly lower accuracy (AUC 0.69-0.71) when 6-11 SNPs were used. A variance partitioning analysis suggests that 55.8% of early-onset MPB genetic liability can be explained by common autosomal SNPs and 23.3% by X-chromosome SNPs. For normal MPB status in elderly individuals, the proportion of explainable variance is lower (42.4% for autosomal and 9.8% for X-chromosome SNPs). The gap between GWAS findings and the variance partitioning results could be explained by a large body of common DNA variants with small effects that will likely be identified in GWAS of increased sample sizes. Although the accuracy obtained here has not reached a clinically desired level, our model was highly informative for up to 19% of Europeans, thus may assist decision making on early MPB intervention actions and in forensic investigations.

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Section: Resultssupporting

confidence: 70%

“…18 MPB status was assessed by trained physicians according to the Norwood-Hamilton grading scale 1,19 with grades 1-12. Cases were defined as grade IV-VIII and otherwise controls.…”

Section: Rotterdam Studymentioning

confidence: 99%

Section: Erasmus Rucphen Family Studymentioning

confidence: 99%

Section: Bonn Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prediction of male-pattern baldness from genotypes

et al. 2015

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Association of Androgenetic Alopecia With Smoking and Its Prevalence Among Asian Men

Chen²

2007

Arch Dermatol

107

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Male Pattern Baldness and Coronary Heart Disease

Lotufo¹,

Chae²,

Ajani³

et al. 2000

Arch Intern Med

133

110

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Objective: To examine the association between male pattern baldness and the risk of coronary heart disease (CHD) events.Design, Setting, and Participants: Retrospective cohort study among 22 071 US male physicians aged 40 to 84 years enrolled in the Physicians' Health Study. Of these, 19 112 were free of CHD at baseline and completed a questionnaire at the 11-year follow-up concerning their pattern of hair loss at age 45 years. Response options included no hair loss, frontal baldness only, or frontal baldness with mild, moderate, or severe vertex baldness. Main Outcome Measures:Coronary heart disease events defined as nonfatal myocardial infarction (MI), angina pectoris, and/or coronary revascularization.Results: During 11 years of follow-up, we documented 1446 CHD events in this cohort. Compared with men with no hair loss, those with frontal baldness had an ageadjusted relative risk (RR) of CHD of 1.09 (95% confidence interval [CI], 0.94-1.25), while those with mild, moderate, or severe vertex baldness had RRs of 1.23 (95% CI, 1.05-1.43), 1.32 (95% CI, 1.10-1.59), and 1.36 (95% CI, 1.11-1.67), respectively (P for trend, Ͻ.001). Multivariate adjustment for age, parental history of MI, height, body mass index (weight in kilograms divided by the square of the height in meters as a continuous variable), smoking, history of hypertension, diabetes, high cholesterol level, physical activity, and alcohol intake did not materially alter these associations. Results were similar when nonfatal MI, angina, and coronary revascularization were examined separately, and when events were analyzed among men older and younger than 55 years at baseline. Vertex baldness was more strongly associated with CHD risk among men with hypertension (multivariate RR, 1.79; 95% CI, 1.31-2.44) or high cholesterol levels (multivariate RR, 2.78; 95% CI, 1.09-7.12). Conclusion:Vertex pattern baldness appears to be a marker for increased risk of CHD events, especially among men with hypertension or high cholesterol levels.

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Male Pattern Baldness: classification and Incidence

Cited by 744 publications

References 0 publications

Prediction of male-pattern baldness from genotypes

Prediction of male-pattern baldness from genotypes

Association of Androgenetic Alopecia With Smoking and Its Prevalence Among Asian Men

Male Pattern Baldness and Coronary Heart Disease

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