Male Sexual Behavior

Siegel, Harold I.

doi:10.1007/978-1-4757-0815-8_9

Cited by 16 publications

(9 citation statements)

References 34 publications

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“…Furthermore, the dysfunction of endocrinological system in B[␣]P-treated mice cannot rule out in view of the evident role of this system in sexual behaviour and aggressiveness [48][49][50][51]. The negative effects of prolonged exposure to B[␣]P on sexual function and aggressiveness in B[␣]P-treated mice may be specific, since B[␣]P (0.02-0.2 mg/kg) does not affect anxiety levels as we have revealed it by using the light/dark choice test (results not shown).…”

Section: Discussionmentioning

confidence: 99%

Subacute oral exposure to benzo[α]pyrene (B[α]P) increases aggressiveness and affects consummatory aspects of sexual behaviour in male mice

Bouayed

Desor

Soulimani

2009

Journal of Hazardous Materials

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Section: Discussionmentioning

confidence: 99%

Subacute oral exposure to benzo[α]pyrene (B[α]P) increases aggressiveness and affects consummatory aspects of sexual behaviour in male mice

Bouayed

Desor

Soulimani

2009

Journal of Hazardous Materials

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“…Rather, mating behavior declines slowly after castration with the complete elimination of sexual behavior occurring 7-10 weeks later (Park, Takasu, Alvarez, Clark, Aimaq, and Zucker, 2004; Siegel, 1985). Conversely, testosterone administration to long-term castrates results in the full recovery of mating after 8 weeks (Sachs and Meisel, 1988; Siegel, 1985; Wood and Newman, 1995a). In the olfactory bulb, the maturation and subsequent activation of newly-proliferated cells occurs across a similar time frame.…”

Section: Discussionmentioning

confidence: 99%

“…Three weeks prior to BrdU injections, half of the animals were castrated. Castration causes a profound loss in circulating androgens, and is accompanied by the elimination of sexual behavior (reviewed in Siegel, 1985; Wood and Newman, 1995a). The other half remained gonad intact.…”

Section: Methodsmentioning

confidence: 99%

Cell proliferation and survival in the mating circuit of adult male hamsters: Effects of testosterone and sexual behavior

Antzoulatos¹,

Magorien²,

Wood³

2008

Hormones and Behavior

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The transient actions of gonadal steroids on the adult brain facilitate social behaviors, including reproduction. In male rodents, testosterone acts in the posterior medial amygdala (MeP) and medial preoptic area (MPOA) to promote mating. Adult neurogenesis occurs in both regions. The current study determined if testosterone and/or sexual behavior promote cell proliferation and survival in MeP and MPOA. Two experiments were conducted using the thymidine analog BrdU. First, gonadintact and castrated male hamsters (n=6/group) were compared 24 hours or 7 weeks after BrdU. In MeP, testosterone stimulated cell proliferation 24 hours after BrdU (intact: 22.8±3.9 cells/mm 2 , castrate: 13.2±1.4cells/mm 2 ). Testosterone did not promote cell proliferation in MPOA. Seven weeks after BrdU, cell survival was sparse in both regions (MeP: 2.5±0.6 and MPOA: 1.7±0.2 cells/mm 2 ), and was not enhanced by testosterone. In Experiment 2, gonad-intact sexually-experienced animals were mated weekly to determine if regular neural activation enhances cell survival 7 weeks after BrdU in MeP and MPOA. Weekly mating failed to increase cell survival in MeP (8.1±1.6 vs. 9.9 ±3.2 cells/mm 2 ) or MPOA (3.9±0.7 vs. 3.4±0.3 cells/mm 2 ). Furthermore, mating at the time of BrdU injection did not stimulate cell proliferation in MeP (8.9±1.7 vs. 8.1±1.6 cells/mm 2 ) or MPOA (3.6 ±0.5 vs. 3.9±0.7 cells/mm 2 ). Taken together, our results demonstrate a limited capacity for neurogenesis in the mating circuitry. Specifically, cell proliferation in MeP and MPOA are differentially influenced by testosterone, and the birth and survival of new cells in either region are not enhanced by reproductive activity.

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“…1000-fold lower than circulating androgens in males [12,103]. Moreover, in gonadectomized male hamsters, mating behavior can be stimulated with only 1.0 µg of estradiol versus 300 µg of testosterone [28,158].…”

Section: • Can't Beat the Real Thing: Reinforcing Effects Of Aas Vs Tmentioning

confidence: 97%

Anabolic–androgenic steroid dependence? Insights from animals and humans

Wood

2008

Frontiers in Neuroendocrinology

136

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Anabolic-androgenic steroids (AAS) are drugs of abuse. They are taken in large quantities by athletes and others to increase performance, with negative health consequences. As a result, in 1991 testosterone and related AAS were declared controlled substances. However, the relative abuse and dependence liability of AAS have not been fully characterized. In humans, it is difficult to separate the direct psychoactive effects of AAS from reinforcement due to their systemic anabolic effects. However, using conditioned place preference and self-administration, studies in animals have demonstrated that AAS are reinforcing in a context where athletic performance is irrelevant. Furthermore, AAS share brain sites of action and neurotransmitter systems in common with other drugs of abuse. In particular, recent evidence links AAS with opioids. In humans, AAS abuse is associated with prescription opioid use. In animals, AAS overdose produces symptoms resembling opioid overdose, and AAS modify the activity of the endogenous opioid system. KeywordsAnabolic agents; Testosterone; self-administration; hamsters; drug dependence • Breakfast of champions: Recent history and prevalence of AAS useAnabolic-androgenic steroids (AAS) are a hot topic. A search of the Google news archive in March 2007 reveals 47,500 news stories on "steroids" in 2006, a 400% increase since their debut in the archive in 2002. In 2006, "steroids" even surpassed trend-setters such as "Paris Hilton" (38,500 stories) or "spinach" (42,700 stories). Current media attention on AAS abuse has been driven by accusations of steroid use among professional athletes in baseball, track, and cycling. However, public recognition of AAS use in sports dates back nearly 20 years, when Ben Johnson tested positive for stanozolol at the Seoul Olympics in 1988 [77]. Eastern Block athletes had been using steroids since the 1950's, and the International Olympic Committee banned steroid use from Olympic competition in 1976. However, the ability to reliably detect androgen metabolites in urine samples was limited until the advent of gas chromatography-mass spectroscopy [89]. Johnson's drug test spurred the United States Congress to pass the Anabolic Steroid Control Act of 1991 which declared steroids as Address all reprint requests and correspondence to Ruth I. Wood, Department of Cell and Neurobiology, Keck School of Medicine at the University of Southern California, 1333 San Pablo St., BMT 401, Los Angeles, CA 90033. Telephone (323) 442-1980, Fax: (323) 442-3466, e-mail: riw@usc.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain....

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Male Sexual Behavior

Cited by 16 publications

References 34 publications

Subacute oral exposure to benzo[α]pyrene (B[α]P) increases aggressiveness and affects consummatory aspects of sexual behaviour in male mice

Subacute oral exposure to benzo[α]pyrene (B[α]P) increases aggressiveness and affects consummatory aspects of sexual behaviour in male mice

Cell proliferation and survival in the mating circuit of adult male hamsters: Effects of testosterone and sexual behavior

Anabolic–androgenic steroid dependence? Insights from animals and humans

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