Male sexual dysfunction: A review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention

Practical Approaches to Treat ED in PDE5i Nonresponders

“…Many diseases are likely associated with ED, causing refractory ED and a poor prognosis. Males who have metabolic syndrome, diabetes, hypertension, coronary heart disease, and hypogonadism, among other conditions, are particularly susceptible to ED [79]. Moreover, the comorbidities of ED are reasons why patients with ED might not respond to PDE5is, although the potential mechanisms differ.…”

“…Therefore, it is necessary to consider the characteristics of the comorbidities during ED treatment with PDE5is, and more suitable PDE5is should be selected for treating ED. Fortunately, an integrated analysis of 11 double-blind, placebo-controlled studies showed that on-demand tadalafil (10 mg or 20 mg) significantly improved the IIEF-EF, SEP-3 and GAQ scores of ED patients with different comorbidities, such as diabetes mellitus, hypertension, cardiovascular disease, hyperlipidemia, depression, and BPH [79]. Therefore, it is believed that tadalafil, a long-acting PDE5i, can significantly improve the erectile function of patients with ED and different comorbidities.…”

Preventive role of Crataegus monogyna on sperm quality and testis oxidative stress against copper-induced toxicity

“…Previous studies showed that human spermatogenesis has decreased by up to 60% after 40 years [5]. In addition, many couples today are infertile [6]; this male sexual disorder may be related to pollutants [7]. The discharge of heavy metals into the environment has led to a harmful deterioration of the ecosystems [8].…”

Psychosexual peculiarities of female partners of men with sexual dysfunctions

“…Она вызвана различными биологическими и психологическими факторами. В мире около 15 % пар страдают от сексуальной дисгармонии, в 40-50 % случаев причиной ее является мужской фактор [1]. Мужская репродуктивная система чувствительна к воздействию многочисленных факторов, таких как хронические заболевания, загрязнение окружающей среды, лекарственная токсичность, нездоровый образ жизни и т. д.…”

“…Так, N. O. Rosen и соавт. из Университета Далхаузи (Dalhousie University, Канада) исследовали 206 пар, в 97 из которых женщины страдали расстройством сексуального интереса и возбуждения 1 . Исследование имело целью установить, влияют ли эти нарушения на партнеров пациенток и сексуальные отношения в паре.…”