Malignancy and Interstitial Pneumonitis as Fatal Complications in Dermatomyositis

Hidano, Akira; Torikai, Sayori; Uemura, Tomoko; Shimizu, Satoru

doi:10.1111/j.1346-8138.1992.tb03199.x

Cited by 39 publications

(10 citation statements)

References 31 publications

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“…An increased incidence of cancer in patients with dermatomyositis (DM) (Hidano et al, 1992;Sigurgeirsson et al, 1992;Rose et al, 1994;Selvaag et al, 1994;Zantos et al, 1994;Airio et al, 1995;Chow et al, 1995;Maos et al, 1998) and polymyositis (PM) (Sigurgeirsson et al, 1992;Zantos et al, 1994;Chow et al, 1995;Maos et al, 1998) has been reported in many studies, though with wide variations in the estimated risks. A few studies did not find an excess risk of cancer (Lakhanpal et al, 1986;Manchul et al, 1998) although these were hospital-based case-control studies of limited size.…”

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confidence: 99%

Risk of cancer in patients with dermatomyositis or polymyositis and follow-up implications: a Scottish population-based cohort study

Stockton¹,

2001

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SummaryWe conducted a national, retrospective population-based cohort study of 705 patients hospitalized with a first diagnosis of dermatomyositis (DM) or polymyositis (PM) during 1982-1996 based on linkage of hospital discharge, cancer registration, and death records in Scotland. Risks of cancer were assessed by calculating standardized incidence ratios (SIR). A first malignancy was diagnosed concurrently or subsequently in 50 patients with DM (SIR 7.7, 95% CI 5.7-10.1), and 40 patients with PM (2.1, 1.5-2.9). Significantly elevated risks were observed for lung, cervix uteri, and ovarian cancer in patients with DM, and for Hodgkin's disease in patients with PM. The excess risk of cancer was highest around the time of diagnosis, and for patients with DM remained high for at least 2 years. Risks were elevated for both sexes but only significantly so for females, and were highest in patients aged 45-74 years at the time of diagnosis for DM and 15-44 for PM.

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Risk of cancer in patients with dermatomyositis or polymyositis and follow-up implications: a Scottish population-based cohort study

Stockton¹,

2001

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“…A strong association of dermatomyositis (DM) with malignancies has often been suggested (1, 2, 5, 6), although the reported frequency varies greatly. Among these complications, cancers of the stomach, lung, breast, uterus and colon are most frequently reported (2,5). Lymphoma accounted for 3.3-6% of the malignancies associated with dermatomyositis (1,2,7).…”

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Dermatomyositis Associated with Primary Intramuscular B Cell Lymphoma

Anzai¹,

Katagiri²,

Sato³

et al. 1997

The Journal of Dermatology

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A rare case of dermatomyositis associated with primary intramuscular malignant lymphoma is described. A 40-year-old Japanese woman noticed swelling of the right thigh during the treatment of dermatomyositis with prednisolone, azathioprine and cyclophosphamide. A biopsy specimen taken from the right quadriceps muscle revealed infiltration of lymphoma cells which were positive for CD20. We reviewed 12 cases of dermatomyositis associated with malignant lymphoma reported in Japanese literature between 1984 and 1996.

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“…It has been reported that those autoantibodies are markers for PMpatients with ILD ( 1-4). In Japan, however, there are some reports in which a rapidly progressive ILD was related to DMpatients without antiJo-1 antibody (6,7,17,18). Takizawa and Ito (19) reported that these patients often showed intractable respiratory failure even if when treated with a high dose or pulse therapy of corticosteroids and survive less than one year after onset.…”

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confidence: 99%

Rapidly Progressive Interstitial Lung Disease in a Dermatomyositis Patient with High Levels of Creatine Phosphokinase, Severe Muscle Symptoms and Positive Anti-Jo-1 Antibody.

Kashiwabara¹,

Ota²

2002

Intern. Med.

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It has been reported that there is a subgroup of dermatomyositis (DM) patients with rapidly progressive interstitial lung disease (ILD) who have mild muscle symptoms, slightly increased levels of muscle enzymes, and absence of anti-Jo-1 antibody. A 51-year-old womanwith DMwas intubated requiring mechanical ventilation because of a rapidly progressing ILD in spite of the absence of the typical poor prognostic factors. A high dose or pulse therapy of corticosteroids was not effective, but additional treatment of cyclosporine gradually improved her respiratory condition. It is not clear whya rapidly progressive ILD occurred in this case lacking poor prognostic factors. However, if corticosteroid treatment is not effective, additional administration of cyclosporine in the early period of rapidly progressive ILD may rescue deteriorating cases. (Intrenal Medicine 41: 584-588, 2002)

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Malignancy and Interstitial Pneumonitis as Fatal Complications in Dermatomyositis

Cited by 39 publications

References 31 publications

Risk of cancer in patients with dermatomyositis or polymyositis and follow-up implications: a Scottish population-based cohort study

Risk of cancer in patients with dermatomyositis or polymyositis and follow-up implications: a Scottish population-based cohort study

Dermatomyositis Associated with Primary Intramuscular B Cell Lymphoma

Rapidly Progressive Interstitial Lung Disease in a Dermatomyositis Patient with High Levels of Creatine Phosphokinase, Severe Muscle Symptoms and Positive Anti-Jo-1 Antibody.

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