Malignancy in Relation to Autoimmune Blistering Dermatoses: Molecular and Clinical Aspects

Pietkiewicz, Paweł; Gornowicz‐Porowska, Justyna; Dmochowska, Monika Bowszyc; Dmochowski, Marian

doi:10.5772/55240

Cited by 7 publications

(5 citation statements)

References 180 publications

(199 reference statements)

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“…[ 4 7 ] The pathogenetic connection between ABD and malignancies remains unclear, however, proinflammatory molecules may lead to tissue damage, chronic inflammation and increased risk of carcinogenesis. [ 8 ] The time-onset relation between ABD and malignancy is as well uncertain. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

Localized Linear IgA Bullous Dermatosis and a Recurrent Cicatricial Ectropion of the Eyelid

Drnovšek-Olup

Matović

2022

Indian Journal of Dermatology

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Cicatrizing ectropion of the eyelid is an uncommon condition, possibly resulting in significant ocular morbidity. A potential cause can be a systemic disease, including autoimmune blistering disease (ABD). We herein report a case with a sixteen-year follow-up of a patient with a chronic cicatrizing unilateral ectropion caused by linear IgA bullous dermatosis (LABD). LABD is an ABD, characterized by the accumulation of IgA anti-basement membrane autoantibodies. It has a varied presentation; however, localized or ophthalmic manifestations have been infrequently described. The case demonstrates the benefits of immunohistochemistry in obtaining the correct diagnosis, and difficulties in the medical and surgical management of a recurrent cicatricial ectropion caused by chronic systemic disease.

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Section: Discussionmentioning

confidence: 99%

Localized Linear IgA Bullous Dermatosis and a Recurrent Cicatricial Ectropion of the Eyelid

Drnovšek-Olup

Matović

2022

Indian Journal of Dermatology

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“…Thus, nail apparatus lesions can be misleading when practicing dermatologists examine just periungual body areas that bother patients most, overlook, and/or misinterpret other lesions. Conversely, nail apparatus involvement, although embarrassing for the patient, can be an invaluable hint as to PV diagnosis when meticulously analyzed in the clinical context, such as symptoms evolution, medical histories including family history, concomitant malignancies ( 59 ), culprit medications ( 60 ), radiation ( 61 ), trauma ( 42 ) and airborne and topical chemical compounds exposure ( 61 – 63 ). Proper treatment, including cessation of triggering factors, can facilitate good control, and faster recovery, reduce the burden of aggressive treatment and prevent aggravation of PV, possibly the lethal disease.…”

Section: Discussionmentioning

confidence: 99%

Involvement of Nail Apparatus in Pemphigus Vulgaris in Ethnic Poles Is Infrequent

et al. 2018

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Pemphigus vulgaris lesions have a tendency to localize around natural body orifices. The aim here was to analyze the involvement of nail apparatus in pemphigus vulgaris. Sixty seven ethnic Poles suffering from pemphigus vulgaris on photographic files archiving initial presentation were retrospectively evaluated. Pemphigus vulgaris was diagnosed using combination of clinical data, H+E histology, direct immunofluorescence of plucked scalp hair and/or perilesional tissue also for IgG1 and IgG4 deposits evaluation, indirect immunofluorescence on mosaic substrate and/or monkey esophagus, mono-analyte ELISA with desmoglein 1/3 or multi-analyte ELISA. The nail apparatus involvement was found in 9 of 67 patients (13.4%; 3 females and 6 males). Periungual fingernail lesions were found in 6 patients (2 females, 4 males), whereas periungual toenail lesions in just 3 patients (1 female, 2 males). Our patients nail apparatus changes included, by order of frequency, paronychia, nail discoloration, onychorrhexis, Beau lines, periungual hemorrhages, onychomadesis, cross-ridging, onycholysis, and trachyonychia. The average time between the onset, as recalled by patients, and the diagnosis of pemphigus vulgaris with direct immunofluorescence was not statistically different in PV patients with and without nail apparatus lesions. In this article the molecular and immunological rationale for of periungual involvement is discussed. Our single-center study suggests that nail apparatus involvement is infrequent in pemphigus vulgaris in ethnic Poles. Due to the fact that nail apparatus lesions in pemphigus vulgaris may clinically resemble onychomycosis, giving the proper diagnosis can be difficult particularly when other lesions are overlooked or misinterpreted.

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“…In a patient with diabetes mellitus treated using metformin and empagliflozin, bullous pemphigoid (BP) developed within the atrophic centres of DSP [225]. It has been speculated that diabetes mellitus or/and empagliflozin could be linked to the emergence of BP [225]; nevertheless, this phenomenon could relate to central scar-like atrophy, as BP has been reported to affect surgical scars [142,226], Wolf's isotopic response [227] or anti-neoplastic immunity in DSP, inducing pathological autoimmune responses to hemidesmosomal components due to the bystander effect [228].…”

Section: Disseminated Superficial Porokeratosis (Dsp) 41 Clinical Pre...mentioning

confidence: 99%

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

Pietkiewicz,

Korecka,

Salwowska

et al. 2023

Metabolites

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Porokeratosis is a heterogeneous group of keratinising disorders characterised by the presence of particular microscopic structural changes, namely the presence of the cornoid lamella. This structure develops as a consequence of a defective isoprenoid pathway, critical for cholesterol synthesis. Commonly recognised variants include disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, porokeratosis of Mibelli, palmoplantar porokeratosis (including porokeratosis palmaris et plantaris disseminata and punctate porokeratosis), linear porokeratosis, verrucous porokeratosis (also known as genitogluteal porokeratosis), follicular porokeratosis and porokeratoma. Apart from the clinical presentation and epidemiology of each variant listed, this review aims at providing up-to-date information on the precise genetic background, introduces imaging methods facilitating the diagnosis (conventional and ultraviolet-induced fluorescence dermatoscopy, reflectance confocal microscopy and pathology), discusses their oncogenic potential and reviews the literature data on the efficacy of the treatment used, including the drugs directly targeting the isoprenoid–mevalonate pathway.

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Malignancy in Relation to Autoimmune Blistering Dermatoses: Molecular and Clinical Aspects

Cited by 7 publications

References 180 publications

Localized Linear IgA Bullous Dermatosis and a Recurrent Cicatricial Ectropion of the Eyelid

Localized Linear IgA Bullous Dermatosis and a Recurrent Cicatricial Ectropion of the Eyelid

Involvement of Nail Apparatus in Pemphigus Vulgaris in Ethnic Poles Is Infrequent

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

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