Malignant ameloblastomas from 1953 to 1966

Ameloblastic carcinoma: a Brazilian collaborative study of 17 cases

“…A diagnosis of AMECA is made when a malignant OT presents as a combination of histological features of AME and anaplasia . Various types of anaplasia have been described in AMECA, such as hypercellularity, basaloid and/or pseudosarcomatous differentiation of the stellate reticulum, loss of ameloblastic differentiation, cell and nuclear pleomorphism, an increased nucleus/cytoplasm ratio, nuclear hyperchromatism, and a high mitotic rate . Moreover, an infiltrative growth pattern, neural and vascular/lymphatic invasion and necrosis have also been utilized to identify the AMECA malignant phenotype …”

“…A diagnosis of AMECA is made when a malignant OT presents as a combination of histological features of AME and anaplasia. 1,12,20,21 Various types of anaplasia have been described in AMECA, such as hypercellularity, basaloid and/or pseudosarcomatous differentiation of the stellate reticulum, loss of ameloblastic differentiation, cell and nuclear pleomorphism, an increased [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][20][21][22][23][24] Moreover, an infiltrative growth pattern, neural and vascular/lymphatic invasion and necrosis have also been utilized to identify the AMECA malignant phenotype. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][20][21][22][23][24] However, as many of these features are not observed in the same tumour, and no single pathological feature ca...…”

“…Malignant counterparts of ameloblastoma (AME) have been recognized for more than 100 years . However, the terminology, classification and histological aspects of malignant odontogenic tumours (OTs) showing ameloblastic differentiation remains an area of uncertainty.…”

Clinicostatistical Study of Ameloblastoma Treatment.

“…Kasahara et al 6) described a repetition marsupialization method for ameloblastoma as a way of removing scar tissue repeatedly after having removed the tumor; they claimed that method was very effective because it not only promoted bone revitalization but also prevented recurrence. However, ameloblastoma does recur, and there are many reports suggesting that malignant transformation can be caused by the added stress of multiple surgery 1,16,23,24) . In this study, one mandibular case died; enucleation was performed as the pri-mary treatment, and the tumor recurred repeatedly and finally underwent malignant transformation.…”

Das Ameloblastom der Nasenhaupthöhle: Eine elektronenmikroskopische Studie

“…Die bekannten Malignitatsmerkmale wie vermehrte Mitosen und Hyperchromasie und Fernmetastasen sind selten bet den malignen Formen des Ameloblastoms anzutreffen. Die lichtmikroskopische Erkennung dieser malignen Varianten 1st somit sehr problematisch, Diagnosen wie adenoidzystische Plattenepithelkarzinome, epitheloide Tumoren aber auch Melanome wurden bisher beobachtet [6,9]. Eine elektronenmikroskopische Untersuchung ist hier daher wegweisend und erganzend [25].…”