Malignant Catarrhal Fever

Sood, Richa; Kumar, Naveen; Bhatia, Sandeep

doi:10.1007/978-3-319-47426-7_16

Cited by 9 publications

(8 citation statements)

References 32 publications

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“…Avoiding co‐farming of cattle with sheep would be the key measure. In the event that it is necessary to share personnel or machinery/equipment between both herds, emphasis should be placed on maintaining adequate protection measures to avoid indirect contagions (i.e., adequate protective clothing and fomites sterilisation) 5,15,26 …”

Section: Discussionmentioning

confidence: 99%

“…In the peracute form, the course is especially rapid, with fever, dysentery and death in 12–24 hours 14,15 …”

Section: Introductionmentioning

confidence: 99%

“…A mild form that occurs with transient fever and small mucosal erosions has also been described. This mild form can progress to a complete cure, convalescence with relapse or chronic MCF, in which persistent bilateral leukoma is the most characteristic sign 14,15 …”

Section: Introductionmentioning

confidence: 99%

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Malignant catarrhal fever in cattle in Spain

Iván¹,

María²,

Aduriz

et al. 2022

Vet Record Case Reports

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We report a case of malignant catarrhal fever in cattle in a mixed herd (ovine/bovine). The case occurred in the Basque Country (north of Spain) in April 2021. The infection was confirmed by polymerase chain reaction in a calf that had developed signs consistent with the 'head and eye' form of the disease. Just before its appearance, a group of five calves born at the farm (including the affected one), aged between 8 and 12 months, were temporarily housed in a pen adjacent to the sheep shed, and separated by a metallic fence that allowed direct contact. In Spain, there are no data on the incidence of malignant catarrhal fever, as there is no active surveillance programme in place. Furthermore, the disease is uncommonly considered in differential diagnoses.

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Section: Discussionmentioning

confidence: 99%

“…In the peracute form, the course is especially rapid, with fever, dysentery and death in 12–24 hours 14,15 …”

Section: Introductionmentioning

confidence: 99%

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Malignant catarrhal fever in cattle in Spain

Iván¹,

María²,

Aduriz

et al. 2022

Vet Record Case Reports

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“…In contrast, OvHV-2 is responsible for sheep-associated-MCF (SA-MCF) disease in susceptible hosts such as buffalo ( 3 ), cattle ( 4 ), deer ( 5 ), and rarely in pig ( 6 ), and foal ( 7 ). The typical clinical signs in the susceptible hosts include pyrexia, anorexia, bilateral corneal opacity, nasal and ocular discharge, ulceration on the mucosa, and neurological manifestations in terminal stages ( 8 ). The most common gross pathological changes in the SA-MCF affected animals are erosions of the tracheal and bronchial mucosa, erythema of the turbinate mucosa, congestion and edema of the lungs, and focal white lesions in the kidney.…”

Section: Introductionmentioning

confidence: 99%

“…Histopathologically, lymphocytic infiltrations and lymphocytic vasculitis are the usual findings in many tissues and organs. In particular, perivascular cuffing is considered as an important feature for the tentative diagnosis of SA-MCF disease ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

First Molecular Evidence and Genetic Characterization of Ovine Herpesvirus 2 in Multiple Animal Species in India

et al. 2021

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Ovine herpesvirus 2 (OvHV-2) is the causative agent of sheep-associated malignant catarrhal fever (SA-MCF), a highly fatal disease syndrome that predominantly affects susceptible hosts of the order Artiodactyla. In this study, an in-depth clinico-molecular investigation of SA-MCF disease in a morbid 50-days-old cattle calf (Bos taurus indicus) and asymptomatic infection in the in-contact reservoir hosts, sheep (Ovis aries), and goat (Capra hircus) housed on a farm located in the Southern India is reported. An OIE recommended SA-MCF type-specific PCR confirmed the etiological agent as OvHV-2. The genetic characterization and phylogenetic analyses based on the glycoprotein B (gB) gene indicate that three genetic variants of OvHV-2 had infected the animal cluster of this study. As the OvHV-2 infection eventually lead to the death of the cattle calf, and the fact that its gB sequence carried four unique amino acid substitutions (N169S, L594P, I645V, and V730A), an investigation of these substitutions impact on its stability and molecular flexibility was carried out. The mapping of these amino acid substitutions on the three-dimensional structure of gB coupled with supplementary investigations showed that these substitutions conveyed the molecular flexibility to the gB, at the cost of its stability. Future studies would be to investigate whether these gB substitutions have any impact on membrane fusion activity using a virus-free cell-to-cell membrane fusion assay. The study also highlights the importance of adopting stringent biosecurity measures where mixed animal farming is a common practice.

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