Malignant change in trichilemmal cysts: a study of cell proliferation and DNA content

Abstract

We have examined proliferative activity in a series of pilar and trichilemmal cysts using an antibody to proliferating cell nuclear antigen. In benign lesions proliferative activity was confined to the basal layers of the squamous epithelium. Lesions showing malignant change showed increased proliferative activity and were not confined to the basal layer. These findings were correlated with studies on DNA content using flow cytometry.

Trichilemmal cyst of the bulbar conjunctiva: A rare presentation

“…[910] In our case, the cyst showed basal cell hyperplasia without cell atypia or mitosis. There are a few reported cases of trichilemmal cyst and malignant trichilemmal tumor of the eyelid.…”

Cytodiagnosis of Simple and Proliferating Trichilemmal Cysts

“…Pilar tumors also show aggressive proliferation that may progress to malignancy. 10,11 The aim of this report is to describe hithertoundescribed fine needle aspiration cytologic (FNAC) findings in 12 pilar cysts and 3 pilar tumors.…”

Metastatic trichilemmal carcinoma in a patient with breast cancer

“…Histologically, one observes increased mitotic activity, increased proliferative index and activity beyond the basal layer of the skin 12. Other features include characteristic trabeculae with peripheral palisading of cells extending to the level of the dermis 7.…”