Malignant Eyelid Tumors in India: A Study of 536 Asian Indian Patients

Abstract

Purpose: To study the proportion of eyelid malignant tumors in an Asian Indian population and to review their clinical features and outcomes. Methods: This is a retrospective study of 536 patients. Results: The mean age at presentation with eyelid malignancy was 58 years. Histopathology-proven diagnoses of these patients included sebaceous gland carcinoma (SGC) (n = 285, 53%), basal cell carcinoma (BCC) (n = 128, 24%), squamous cell carcinoma (SCC) (n = 99, 18%), and miscellaneous tumors (n = 24, 4%). The statistically significant differences between eyelid malignant tumors included age at presentation, tumor location, and tumor extent. The clinicopathological correlation of SGC, BCC, SCC, and miscellaneous tumors was 91, 86, 46, and 38% (p = 0.001), respectively. Comparing SGC with BCC, SCC, and miscellaneous tumors, SGC was more commonly associated with tumor recurrence (21 vs. 3, 8, and 13%; p = 0.001), systemic metastasis (13 vs. 0, 4, and 13%; p = 0.001), and death (9 vs. 0, 4, and 0%; p = 0.004). Compared to SGC, BCC, and SCC, locoregional lymph node metastasis was more common with miscellaneous tumors (26 vs. 16, < 1, and 8%; p = 0.001) over a mean follow-up period of 19 months. Conclusion: In Asian Indians, SGC is twice as common as BCC and 3 times more common than SCC. SGC is associated with poorer prognosis compared to other eyelid malignant tumors.

Clinico-pathological Analysis of Malignant Eyelid and Adnexal Tumors Presenting to a Tertiary Eye Hospital Of Eastern Nepal

“…No case of melanoma was seen in this study.When we see gender predilec on of these tumours, our study shows that SCC is more common in male than in female (7 cases and 1 case respec vely). Whereas a study done by Kaliki S. et.al showed slight female12…”

Epidemiology of Eyelid Malignancies in Indian Asians: The Importance of Being Earnest

“…Indeed, the first reports on malignant eyelid tumors were only published as recently as 1996, albeit small institution-based reports. Kaliki et al [1] from Hyderabad, India, have gone some way in rectifying this deficiency: they have compiled an important analysis of 536 malignant eyelid tumors seen at their institution over a 22-year period. Histopathology-proven diagnoses of these patients included sebaceous gland carcinoma (SGC; n = 285, 53%), basal cell carcinoma (BCC; n = 128, 24%), squamous cell carcinoma (SCC; n = 99, 18%), and miscellaneous tumors ( n = 24, 4%).…”

“…The authors [1] recognize that referral bias to their tertiary care referral institution may play a role in the observed difference of eyelid tumor proportions. The referral of BCCs would be much lower compared to other tumors since these tumors may have been more easily managed by referring physicians.…”

“…What was not discussed in this paper [1] (understandably) is the variation in skin types in the Indian subcontinent. What are the relative Fitzpatrick skin types in the Indian subcontinent?…”

Primitive Ocular Cancers in the University Hospital of Brazzaville

“…Primitive ocular cancer pathology affects all age groups. It is present in both men and women in similar proportions [1,2,14]. In Brazzaville these cancers develop mainly at the expense of three structures, the conjunctiva, the retina and the eyelids.…”