Malignant Hyperpyrexia and Sudden Infant Death

Denborough, M. A.; Galloway, Graham J.; Hopkinson, K.C.

doi:10.1016/s0140-6736(82)90005-8

Cited by 69 publications

(23 citation statements)

References 13 publications

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“…It has been suggested that the rare autosomal dominant disorder of malignant hyperthermia (MH) is associated with SIDS, but a relationship has not been established 12 , 112 . One study showed 6 out of 16 parents of infants who died of SIDS had the underlying muscle membrane disorder which predisposes to MH 113 . This inherited disorder is usually triggered by anaesthesia, but humans with the disorder are also predisposed to heatstroke.…”

Section: Individual Risk Factorsmentioning

confidence: 99%

“…12,112 One study showed 6 out of 16 parents of infants who died of SIDS had the underlying muscle membrane disorder which predisposes to MH. 113 This inherited disorder is usually triggered by anaesthesia, but humans with the disorder are also predisposed to heatstroke. Studies in pigs with the same muscle disorder have shown that overheating alone can trigger fatal MH.…”

Section: Hyperthermiamentioning

confidence: 99%

See 1 more Smart Citation

Review of risk factors for Sudden Infant Death Syndrome

Sullivan

Barlow²

2001

Paediatric Perinatal Epid

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Sudden infant death syndrome (SIDS) accounts for the largest number of deaths during the first year of life in developed countries. The possible causes of SIDS are numerous and, to date, there is no adequate unifying pathological explanation for SIDS. Epidemiological studies have played a key role in identifying risk factors, knowledge of which has underpinned successful preventive programmes. This review critically assesses information on the main risk factors and causal hypotheses put forward for SIDS, focusing on research published since 1994. The overall picture that emerges from this review is that affected infants are not completely normal in development, but possess some inherent weakness, which may only become obvious when the infant is subjected to stress. Initially there may be some minor impairment or delay in development of respiratory, cardiovascular or neuromuscular function. None of these is likely to be sufficient, in isolation, to cause death and, provided the infant survives the first year of life, may no longer be of any significance. However, when a compromised infant is confronted with one or more stressful situations, several of which are now clearly identified as risk factors, and from which the majority of infants would normally escape, the combination may prove fatal.

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Section: Individual Risk Factorsmentioning

confidence: 99%

Section: Hyperthermiamentioning

confidence: 99%

Review of risk factors for Sudden Infant Death Syndrome

Sullivan

Barlow²

2001

Paediatric Perinatal Epid

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show abstract

“…Whether "stress" in humans plays the same important role as in pigs is not clear at the present time. 24 Besides the possible or probable importance of physical or psychological stress, there might be a number of so far unknown factors, which could trigger MH in individuals genetically prone to the syndrome. The only conclusion at the time is, that MH probably is not confined to the state of anaesthesia.…”

Section: Discussionmentioning

confidence: 99%

Postoperative malignant hyper-thermia and dantrolene therapy

1983

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“…These include malignant hyperthermia, familial Alzheimer's disease, oligodendrogliomas, and myotonic dystrophy [7]. It is of interest that malignant hyperthermia has also been reported in families with SIDS cases [8,9]. More extensive study, however, has failed to reveal a significant association [10,11].…”

Section: Lelter To the Editormentioning

confidence: 99%

Letter to the Editor

1994

Pediatric Pathology

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Malignant Hyperpyrexia and Sudden Infant Death

Cited by 69 publications

References 13 publications

Review of risk factors for Sudden Infant Death Syndrome

Review of risk factors for Sudden Infant Death Syndrome

Postoperative malignant hyper-thermia and dantrolene therapy

Letter to the Editor

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