Malignant hyperthermia

Takimoto, Toru; Satō, Hiroshi; Ogura, Hisashi; Tanaka, Saichiro; Masuda, Koh; Ishikawa, Shigeru; Umeda, Ryozo

doi:10.1288/00005537-198910000-00016

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…Type 1 is dominant in the Western hemisphere and Southeast Asia, whereas types 1 and 2 are equally prevalent in Africa (169,224). These isolates are distinguished by their restriction endonuclease digestion patterns and exhibit different transforming capabilities (1,170,199) and the ability to spontaneously enter the lytic cycle (31).…”

Section: Biology Of Ebvmentioning

confidence: 99%

Progress and Problems in Understanding and Managing Primary Epstein-Barr Virus Infections

2011

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SUMMARY Epstein-Barr virus (EBV) is a gammaherpesvirus that infects a large fraction of the human population. Primary infection is often asymptomatic but results in lifelong infection, which is kept in check by the host immune system. In some cases, primary infection can result in infectious mononucleosis. Furthermore, when host-virus balance is not achieved, the virus can drive potentially lethal lymphoproliferation and lymphomagenesis. In this review, we describe the biology of EBV and the host immune response. We review the diagnosis of EBV infection and discuss the characteristics and pathogenesis of infectious mononucleosis. These topics are approached in the context of developing therapeutic and preventative strategies.

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Section: Biology Of Ebvmentioning

confidence: 99%

Progress and Problems in Understanding and Managing Primary Epstein-Barr Virus Infections

2011

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“…To investigate whether LMP1 alone can induce SATB1 expression, we transiently transfected LMP1 into two EBVnegative human NP cell lines, Ad-AH (Takimoto et al, 1988) and NP69 (Tsao et al, 2002b) and observed significant increases in levels of SATB1 protein and RNA in both sets of cell lines (Fig. 1c).…”

mentioning

confidence: 99%

Upregulation of special AT-rich-binding protein 1 by Epstein–Barr virus latent membrane protein 1 in human nasopharyngeal cells and nasopharyngeal cancer

Endo

Shackelford

Aga

et al. 2013

Journal of General Virology

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A global regulator of chromatin remodelling and gene expression, special AT-rich-binding protein 1 (SATB1) has been implicated in promotion of growth and metastasis of a number of cancers. Here, we demonstrate that the principal oncogene of Epstein-Barr virus (EBV), latent membrane protein 1 (LMP1) upregulates SATB1 RNA and protein expression in human nasopharyngeal cell lines. Silencing of endogenously expressed SATB1 with specific short hairpin RNA decreases cell proliferation and resistance to apoptosis induced by growth factor withdrawal. Additionally, we provide evidence that LMP1-mediated expression of Survivin, a multifunctional protein involved in promoting cell growth and survival, is mediated at least in part by SATB1 in human nasopharyngeal cells. Finally, we show that SATB1 protein levels are elevated in tissue samples from patients with nasopharyngeal carcinoma (NPC), and are directly correlated with the expression of LMP1. Taken together, our results suggest that SATB1 functions as a prometastatic effector of LMP1 signalling in EBV-positive NPC.Special AT-rich sequence-binding protein 1 (SATB1) was originally identified as protein binding to matrix attachment regions (MARs) of unpaired DNA (Dickinson et al., 1992;Sun et al., 2006). SATB1 was shown to regulate distant genes by selectively tethering MARs to the nuclear matrix, resulting in the formation of a characteristic 'cagelike' network that circumscribes heterochromatin (Cai et al., 2003). Furthermore, SATB1 acts as a 'docking site' for several chromatin modifiers (Kumar et al., 2005;Yasui et al., 2002), and these chromatin modifiers were suggested to suppress gene expression through histone deacetylation and nucleosome remodelling at SATB1-bound MARs (Yasui et al., 2002). Phosphorylation of SATB1 might act as a molecular switch in determining whether the protein acts as a transcriptional activator or repressor (Pavan Kumar et al., 2006). Recently, SATB1 has attracted considerable attention due to its elevated expression in advanced stages of various types of malignant tumours, such as breast, gastric, colorectal and laryngeal carcinomas, which suggests a crucial role in promoting tumour invasion and metastasis (Cheng et al., 2010;Han et al., 2008;Iorns et al., 2010;Lu et al., 2011;Meng et al., 2012;Patani et al., 2009;Shushan et al., 2009;Zhao et al., 2010;Zheng, 2008). However, although there are reports that SATB1 regulates transcription of genes that have direct impact on cellular proliferation and apoptosis (Alvarez et al., 2000;Kumar et al., 2007), the mechanism by which SATB1 regulates these phenomena is still unclear and even controversial (Iorns et al., 2010;Li et al., 2007). Nasopharyngeal carcinoma (NPC) is the most common Epstein-Barr virus (EBV)-associated tumour, and it is noteworthy for its proclivity to early invasion and metastasis (Burgos, 2005;Pagano, 2009;Wakisaka & Pagano, 2003;Zheng et al., 2007). The principal EBV oncoprotein LMP1, a member of the tumour necrosis factor receptor superfamily, is detected in at least 70 % o...

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Lipid bands of approx. 1740 cm−1 as spectral biomarkers and image of tissue oxidative stress

Pielesz

Biniaś²,

Waksmańska³

et al. 2023

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Malignant hyperthermia

Cited by 5 publications

References 13 publications

Progress and Problems in Understanding and Managing Primary Epstein-Barr Virus Infections

Progress and Problems in Understanding and Managing Primary Epstein-Barr Virus Infections

Upregulation of special AT-rich-binding protein 1 by Epstein–Barr virus latent membrane protein 1 in human nasopharyngeal cells and nasopharyngeal cancer

Lipid bands of approx. 1740 cm−1 as spectral biomarkers and image of tissue oxidative stress

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