Malignant hyperthermia: A statistical review

Association of postanaesthetic hyperthermia with abnormal muscle characteristics: A case report

“…6'7 In contrast to the patient reported by Britt, 293 our patient's CK level was elevated following the episode suggesting the presence of skeletal muscle damage. 6 Laboratory studies measuring the in vitro contracture response to caffeine and halothane have been utilized to distinguish MH muscle from normal muscle. There is agreement that muscle from rigid MH patients does produce contractures at a lower caffeine concentration than muscle from normal individuals.…”

How Personalized Medicine Became Genetic, and Racial: Werner Kalow and the Formations of Pharmacogenetics

“…Studies in fourteen families at the Hospital for Sick Children in Toronto found a frequency of 1:14,000, "All three major racial groups --Oriental, Negro, and Caucasian --were involved." 110 Research in rabbits, rats, dogs, chickens, and pigs revealed a similar syndrome in pigs, but with a different underlying pathophysiology. 111 Second, Kalow continued to publish review articles that emphasized the relevance of pharmacogenetics.…”

Hipertermia maligna: ¿cómo estar preparados?

“…Con respecto a la inci-dencia de la enfermedad se estima en 1 en 15.000 anestesias en niños y adolescentes y 1 en 50.000 a 150.000 anestesias en adultos 4 . Sin embargo, existen grandes variaciones en las tasas de incidencias publicadas, probablemente debidas tanto a la diversidad geográfica, a los diferentes métodos diagnósticos utilizados, a la falta de reporte como a los diferentes denominadores usados en los diversos estudios [5][6][7][8][9] . En un estudio reciente Brady y cols 9 , reportaron una prevalencia de 0,96 por cada 100.000 procedimientos quirúrgicos.…”