Malignant Interstitial Cell Tumor of the Testis: Case Report and Review

Silverberg, Steven G.; Thompson, J. Will; Higashi, Gene I.; Baskin, Arnold M.

doi:10.1016/s0022-5347(17)63268-3

Cited by 27 publications

(2 citation statements)

References 10 publications

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“…Metastatic disease frequently involves the lymph nodes (70%), particularly the retroperitoneal and inguinal lymph nodes. Other frequent metastatic regions are the liver (45%), lung (40%), and bones (25%) [ 1 , 6 ]. In the present case, RPLN metastasis was observed at the first visit itself.…”

Section: Discussionmentioning

confidence: 99%

“…5 The Division of Hospital and Clinic Coordination, Japan Community Health Care Organization, Kani Tono Hospital, 1221-5 Dota, Kani, Gifu 509-0206, Japan. 6 The Division of Radiology, Japan Community Health Care Organization, Kani Tono Hospital, 1221-5 Dota, Kani, Gifu 509-0206, Japan. Morinaga et al Journal of Medical Case Reports (2022) 16:406…”

Section: Abbreviationsmentioning

confidence: 99%

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Malignant testicular unclassified sex cord stromal tumor: a case report

et al. 2022

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Background Most testicular tumors are germ cell tumors; sex cord stromal tumors are infrequent, accounting for only 3–5% of testicular tumors. Unclassified sex cord stromal tumors are extremely rare. Generally, 10% of sex cord stromal tumors are malignant. We report a case of malignant unclassified sex cord stromal tumor with retroperitoneal lymph node metastasis at first visit and a corresponding literature review. Case presentation A 72-year-old Japanese man visited our department primarily for indolent right scrotum enlargement in September 2020. Blood biochemistry examination, urinalysis, and tumor markers (alpha-fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase) showed no abnormal findings. Contrast-enhanced computed tomography showed enlarged para-aortic lymph node (18 × 16 and 10 × 102 mm); a 50 × 452 mm mass with uneven contents was found in the right testicle. The patient underwent inguinal orchiectomy in September 2020. As per immunohistochemistry, the tumor cells were diffusely positive for SF-1 and Ki-67, partially positive for inhibin, and negative for CAM5.2, CK7, CK20, C-KIT, CD30, LCA, GATA-3, TTF-1, and PAX8. Calretinin was expressed in approximately 5% of tumor cells; thus, sex cord/gonadal stroma components were considered to be involved. The final pathological diagnosis was unclassified malignant sex cord stromal tumor. The patient was diagnosed with pT1, N1, M0, S0, and tumor–node–metastasis stage IIA disease. The patient received postoperative chemotherapy with four courses of etoposide and cisplatin therapy from November 2020. Post-chemotherapeutic computed tomography showed new metastatic lesions including lung, liver, pancreas, and para-aortic lymphadenopathy, which increased in size. Disease progression was observed. Cancer genome research was performed using the OncoGuide National Cancer Center oncopanel system; however, no gene mutation for which the drug could be expected to be effective was found. The patient opted for best supportive care at a nearby hospital and died from cancer progression in January 2022. Conclusion We encountered a case of malignant testicular unclassified sex cord stromal tumor pathologically diagnosed as testicular tumor with retroperitoneal lymph node metastasis in a patient who underwent inguinal orchiectomy. Future data collection is necessary to establish multimodality therapy for malignant testicular unclassified sex cord stromal tumor.

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Section: Discussionmentioning

confidence: 99%

Section: Abbreviationsmentioning

confidence: 99%

Malignant testicular unclassified sex cord stromal tumor: a case report

et al. 2022

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Malignant interstitial cell testicular tumor

Mahon

Gosset

Trinity

et al. 1973

Cancer

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The 13th case of malignant interstitial cell tumor of the testicle is reported, and review of the literature made. Six cases of malignant interstitial cell tumor were associated with hydroceles. Absence of urinary chorionic gonadotropin levels does not indicate a more favorable prognosis. The average age at discovery of malignant interstitial cell tumor is 60 years. Retroperitoneal lymph nodes, lung, liver, and bones are the most frequent sites of metastatic involvement. The best treatment appears to be radical orchiectomy and surgical resection of metastases. Chemotherapy may offer remission when surgical resection of metastases is not possible.

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Malignant interstitial cell carcinoma of the testis: Report of two cases with steroid synthetic profiles, response to therapy, and review of the literature

Davis

Martino²,

Schneider³

1981

Cancer

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Two cases of malignant interstitial cell carcinoma of the testis are reported. The first patient had no evidence of a virilizing syndrome. Basal plasma testosterone (T) was decreased, whereas plasma luteinizing hormone, estrone (E1), and androstenedione were elevated. These findings were diagnostic of a defect in T secretion as a result of a partial 17‐hydroxysteroid dehydrogenase deficiency as seen in male pseudohermaphroditism. In the second patient, showing gynecomastia and atrophic testis, endocrine studies revealed high plasma T and estradiol (E2); all measured Δ4 and Δ5 precursors of T were elevated resembling the pattern seen in virilizing adrenal carcinomas. Both patients were treated with radiotherapy without demonstrable effect. Chemotherapy—consisting of a combination of cis‐platinum, vinblastine, and bleomycin; then cyclophosphamide, doxorubicin, and vincristine; and finally o, p′‐DDD—was unsuccessful in reducing tumor bulk. Since malignant Leydig cell carcinomas are rare, this paper reviews the literature and makes recommendations concerning treatment.

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Malignant Interstitial Cell Tumor of the Testis: Case Report and Review

Cited by 27 publications

References 10 publications

Malignant testicular unclassified sex cord stromal tumor: a case report

Malignant testicular unclassified sex cord stromal tumor: a case report

Malignant interstitial cell testicular tumor

Malignant interstitial cell carcinoma of the testis: Report of two cases with steroid synthetic profiles, response to therapy, and review of the literature

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