Malignant lymphoma presenting with a high eosinophilia, eosinophilic pleurisy, and pericarditis

High Eo-CSF activity in T-cell non-Hodgkin's lymphoma with eosinophilia

“…Eosinophilia is known to associate with a variety of diseases. In recent years, investigators have described the presence of eosinophilia in NHL (Catovsky et al 1980;Henderson et al 1969;Ishii et al 1987;Jacobs et al 1982;Keidan et al 1985;Krawietz et al 1984;Manthorpe et al 1977;Reddy et al 1984;Vukelja et al 1988;Watanabe et al 1989). But the mechanism of eosinophilia remains obscure.…”

“…It is only rarely encountered in the patient with non-Hodgkin's lymphoma (NHL). There are a number of reports of NHL patients with eosinophilia (Catovsky et al 1980;Henderson et al 1969;Ishii et al 1987;Jacobs et al 1982;Keidan et al 1985;Krawietz et al 1984;Manthorpe et al 1977;Reddy et al 1984;Vukelja et al 1988;Watanabe et al 1989), but the mechanism of these cases has not been demonstrated yet. We report on a patient with hypereosinophilia and T-cell-type NHL, and its association in particular with the activity of interleukin-5 (IL-5) is analysed.…”

Malignant lymphoma associated with marked eosinophilia

“…Eosinophilia may be a component of the myeloproliferative disorderspolycythemia Vera, myelofibrosis with myeloid metaplasia, and chronic myelocytic leukemia. Eosinophilia may also be associated with many types of neoplasms including lung and brain tumors, melanoma and epithelial tumors [8] , and hematologic neoplasms, such as mycosis fungoides, Hodgkin disease [5, , and non-Hodgkin lymphomas [ l , 5,…”

“…Since the marrow aspirates of rats with lymphoma do not show increased eosinophil precursors, and since no excess tissue eosinophils are found, it is concluded that the eosinophilia is most likely due to inhibition of leukocyte emigration. By contrast, lymphomas in humans often respond dramatically by reductions in peripheral blood eosinophilia following therapy with prednisolone [5] .…”

Hodgkin’s Lymphoma as an Unusual Cause of Eosinophilic Pleural Effusion

“…Here, we present a rare case of eosinophilic pleural effusion caused by a specific histological type of Hodgkin's lymphoma. To our best knowledge, eosinophilic pleural effusion is rarely associated with Hodgkin's lymphoma, with very few available case reports [2,3].…”