Malignant lymphoma with splenic rupture presenting as acute hepatic failure

Acute liver failure associated with diffuse large B-cell lymphoma: an autopsy case report

“…Of note, ALF due to diffuse large B-cell lymphoma is reported to account for only 0.26% (5/1910) [1]; to date, only ten cases of ALF due to diffuse large B-cell lymphoma have been reported (Table 1) [6][7][8][9][10][11][12][13][14][15], with the time to death following admission in six reported cases being 5 days [12,13], 8 days [7,9], 14 days [14], and 19 days [6], in contrast to only 3 days in the present case. It has been reported that the deaths were caused by multi-organ failure involving cardiovascular collapse, acute lung injury, and renal failure, in addition to hepatic failure [5].…”

“…It has been reported that the deaths were caused by multi-organ failure involving cardiovascular collapse, acute lung injury, and renal failure, in addition to hepatic failure [5]. Recently, Sakae et al reported an autopsy report demonstrating the spread of malignant lymphoma to multiple lymph nodes, as well as the spleen, liver, lung, epicardium, adrenal glands, prostate, and bone marrow [12].…”

“…5 [10] 2014 71 M US: fatty liver, mild splenomegaly, and mild distended gallbladder CT: multiple hypodense splenic lesions, a confluent non-compressing circum-aortic mass, multiple para-aortic and pelvic lymph nodes, and bilateral pulmonary nodules Lymph node biopsy Chemotherapy Dead 6 [11] 2016 60 M CT: hepatosplenomegaly BM biopsy Chemotherapy Alive 7 [12] 2016 66 M US: splenomegaly and a hyperechoic mass in the spleen CT: hepatosplenomegaly and a mass with fluid-fluid levels in the spleen Autopsy (-) Dead (day 5)…”