Malignant myoepithelioma of soft tissue: a case report with cytogenetic findings

Balogh, Zsuzsanna; Deák, Linda; Szepes, Zoltán

doi:10.1016/j.cancergencyto.2008.02.013

Cited by 18 publications

(12 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However in contrast to chondroid lipoma, myoepithelioma lacks adipocytes and lipoblasts and features significantly stronger immunoreactivity to antibodies for epithelial differentiation. Cytogenetic or array comparative genomic hybridization studies of soft tissue myoepitheliomas are rare, however, EWSR1 rearrangements or deletion within 19p13 have been identified as recurrent anomalies in subsets of these neoplasms (van den Berg et al, 2004; Balogh et al, 2008; Brandal et al, 2008; Hallor et al, 2008; Brandal et al, 2009). …”

Section: Discussionmentioning

confidence: 99%

C11orf95‐MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma

Huang

Sümegi

Cin

et al. 2010

Genes Chromosomes & Cancer

View full text Add to dashboard Cite

Chondroid lipoma, a rare benign adipose tissue tumor, may histologically resemble myxoid liposarcoma or extraskeletal myxoid chondrosarcoma, but is genetically distinct. In the current study, an identical reciprocal translocation, t(11;16)(q13;p13) was identified in three chondroid lipomas, a finding consistent with previous isolated reports. A fluorescence in situ hybridization (FISH)-based positional cloning strategy using a series of bacterial artificial chromosome (BAC) probe combinations designed to narrow the 16p13 breakpoint revealed MKL2 as the candidate gene. Subsequent 5′ RACE studies demonstrated C11orf95 as the MKL2 fusion gene partner. MKL/myocardin-like 2 (MKL2) encodes myocardin-related transcription factor B (MRTF-B) in a megakaryoblastic leukemia gene family, and C11orf95 (chromosome 11 open reading frame 95) is a hypothetical protein. Sequencing analysis of RT-PCR generated transcripts from all three chondroid lipomas defined the fusion as occurring between exons 5 and 9 of C11orf95 and MKL2, respectively. Dual-color breakpoint spanning probe sets custom-designed for recognition of the translocation event in interphase cells confirmed the anticipated rearrangements of the C11orf95 and MKL2 loci in all cases. The FISH and RT-PCR assays developed in this study can serve as diagnostic adjuncts for identification of this novel C11orf95-MKL2 fusion oncogene in chondroid lipoma.

show abstract

Section: Discussionmentioning

confidence: 99%

C11orf95‐MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma

Huang

Sümegi

Cin

et al. 2010

Genes Chromosomes & Cancer

View full text Add to dashboard Cite

show abstract

“…The EWSR1-ATF1 fusion detected by RT-PCR comprised an in-frame fusion of EWSR1 exon 8 with ATF1 exon 4. 39 Although EWSR1 gene arrangement is found in a significant proportion of both benign and malignant myoepithelial tumors of soft tissue, bone, lung, 8,[12][13][14] and skin, 40 the partner genes described have not previously included ATF1. It remains to be seen whether this remains an isolated case or if, as might be likely, EWSR1-ATF1 fusions will be increasingly noted in other myoepithelial tumors.…”

Section: Myoepithelial Tumor Of Soft Tissuementioning

confidence: 96%

“…These are lobulated tumors composed of cords and clusters of predominantly bland, ovoid, polygonal, or spindle cells within lightly basophilic myxoid stroma [12][13][14], morphologically resembling EMC, although some cases show at least a focal solid pattern; however, PPMS lacks the characteristic translocations of EMC that fuse NR4A3 on chromosome 9q22 with a range of partners. 11,22,52,70,82,85,86,88 There may be variable focal atypia, but no frank anaplasia.…”

Section: Clear Cell Sarcoma-like Tumor Of the Gastrointestinal Tractmentioning

confidence: 97%

Tumors With EWSR1-CREB1 and EWSR1-ATF1 Fusions

Thway

Fisher

2012

American Journal of Surgical Pathology

215

165

View full text Add to dashboard Cite

EWSR1-CREB1 and EWSR1-ATF1 are gene fusions of which one or both have now been consistently described in 5 histopathologically and behaviorally diverse neoplasms: angiomatoid fibrous histiocytoma, conventional clear cell sarcoma (of tendons and aponeuroses), clear cell sarcoma-like tumor of the gastrointestinal tract, hyalinizing clear cell carcinoma of the salivary gland, and primary pulmonary myxoid sarcoma. Some of the tumors in this group have been described only recently, and others have been the subject of recent genetic insights contributing to their characterization. These neoplasms are all rare; yet, the increasing frequency with which EWSR1-CREB1 and EWSR1-ATF1 fusions are being described in separate entities is noteworthy. The additional molecular mechanisms by which tumors with such variable morphologic, immunohistochemical, and clinical phenotypes are generated are yet to be understood. We review the clinicopathologic and molecular features of this group of neoplasms unified by the presence of EWSR1-CREB1 and EWSR1-ATF1 genetic fusions.

show abstract

“…We did not include any lesions that involved both dermal and soft tissue, as these are better classified as cutaneous lesions. With these criteria, we identified a total of 58 cases of soft tissue myoepithelial carcinoma (Table ) …”

Section: Discussionmentioning

confidence: 99%

Neoadjuvant radiation therapy for the management of myoepithelial carcinoma of the upper extremity

Kabarriti

Quinn

Ewart

et al. 2017

Intl Journal of Cancer

View full text Add to dashboard Cite

Myoepithelial tumors of the soft tissue are a rare tumor displaying myoepithelial elements and lacking obvious ductal differentiation. The rarity of these precludes any evidence-based consensus regarding optimal management. Nevertheless, the current approach to these lesions begins with amputation or complete excision. The efficacy of neoadjuvant or adjuvant radiation therapy or chemotherapy has not been established. Here, we present the first report to the authors’ knowledge of neoadjuvant radiation therapy for the treatment of this rare soft tissue neoplasm and review the management and outcomes of published cases of myoepithelial carcinoma. A patient with a soft tissue myoepithelial carcinoma that declined both amputation and chemotherapy was treated with neoadjuvant radiation therapy and wide surgical excision followed by a brachytherapy boost to the resected tumor bed. Neoadjuvant radiation therapy resulted in an excellent response with extensive treatment-related changes consisting predominantly of fibrosis, hyalinization and hemorrhage and only 10% residual viable myoepithelial carcinoma present in the surgical specimen.

show abstract

Malignant myoepithelioma of soft tissue: a case report with cytogenetic findings

Cited by 18 publications

References 15 publications

C11orf95‐MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma

C11orf95‐MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma

Tumors With EWSR1-CREB1 and EWSR1-ATF1 Fusions

Neoadjuvant radiation therapy for the management of myoepithelial carcinoma of the upper extremity

Contact Info

Product

Resources

About