Malignant peripheral nerve sheath tumors of the spine: A SEER database analysis

Stadler, James A.; Qadri, Usama; Tang, Jessica; Melkonian, Stephanie C.; Smith, Zachary A.; Lam, Sandi

doi:10.1016/j.jocn.2014.01.003

Cited by 9 publications

(11 citation statements)

References 27 publications

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“…In our cohort, the analysis of epidemiological feature of MPNST showed an obvious predilection of female (M: F=0.68:1) and the peak age ranged from 41 to 50 years. Our result showed the epidemiologic characteristic of age predilection was in concordance with the previous study in SEER database, but gender predilection of MPNST at the sacrum was not similar to the result of SEER database [14].…”

Section: Gender and Location Distribution Of Sacral Tumors And Tumor-supporting

confidence: 80%

“…Their mean age at diagnosis was 50.9 years with more patients in the higher age group and fty-six percent of patients were male. However, it had no description of the incidence at the sacrum [14]. In our cohort, the analysis of epidemiological feature of MPNST showed an obvious predilection of female (M: F=0.68:1) and the peak age ranged from 41 to 50 years.…”

Section: Gender and Location Distribution Of Sacral Tumors And Tumor-mentioning

confidence: 64%

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Epidemiological characteristics of 1385 sacral tumors and tumor-like lesions not including metastatic cancers in one institution in China

Wang¹,

Li²,

Yang³

et al. 2020

Preprint

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Background: Sacral tumors and tumor-like lesions are a rare group of lesions that can affect children and adults of all ages. Little is known about the epidemiological characteristics of them in China. Methods: 1385 patients with sacral tumors and tumor-like lesions, which had the clinical record at our bone tumor center from 2000 to November 2018 were analyzed. The metastatic cancers were not included in the present study. Results: 51.7% (716 cases) were malignant and 48.3 % (669 cases) were benign tumors or tumor-like lesions. Of malignant tumors, chordoma was the most common malignant tumor (316 cases, 22.8% of all tumors), followed by chondrosarcoma, myeloma and other histologic types. The most common histological type of benign tumors was giant cell tumor accounting for 14.8% (205 cases) of all tumors, followed by neurofibroma, schwannoma and other types. The most common age group affected by malignant bone tumors was the 51- to 60-year-old group, followed by the 41- to 50-year-old group. The most commonly affected age group for benign tumors and tumor-like lesions was the 31- to 50-year-old group, followed by the 21- to 30-year old group. Furthermore, the following histologic types had the gender predilection. Chordoma, chondrosarcoma, myeloma and osteosarcoma affected more frequently males than females. Malignant peripheral nerve sheath tumor, lymphoma, giant cell tumor, neurofibroma, tuberculosis, teratoma and epidermoid cyst more frequently affected females than males. Conclusions: The large cohort of sacral tumors and tumor-like lesions in our database may reveal their epidemiologic characteristics in China and epidemiological feature of sacral tumors and tumor-like lesions is fairly distinct from the mobile spine and extremities.

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Section: Gender and Location Distribution Of Sacral Tumors And Tumor-supporting

confidence: 80%

Section: Gender and Location Distribution Of Sacral Tumors And Tumor-mentioning

confidence: 64%

Epidemiological characteristics of 1385 sacral tumors and tumor-like lesions not including metastatic cancers in one institution in China

Wang¹,

Li²,

Yang³

et al. 2020

Preprint

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“…17 Malignant PNSTs have a worse prognosis than neurofibromas and schwannomas with an incidence of 1 case in 10,000 persons, but they are more common in patients with NF1, where over half of these tumors are found. 25 Spinal nerve sheath tumors are rare entities, and published studies are limited to single-institution case series. 3,6,8,11,14,[22][23][24] Studies focusing purely on surgical complications are limited.…”

mentioning

confidence: 99%

Neurological outcomes and surgical complications in 221 spinal nerve sheath tumors

Safaee

Lyon

Barbaro

et al. 2017

SPI

114

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OBJECTIVE Among all primary spinal neoplasms, approximately two-thirds are intradural extramedullary lesions; nerve sheath tumors, mainly neurofibromas and schwannomas, comprise approximately half of them. Given the rarity of these lesions, reports of surgical complications are limited. The aim of this study was to identify the rates of new or worsening neurological deficits and surgical complications associated with the resection of spinal nerve sheath tumors and the potential factors related to these outcomes. METHODS Patients were identified through a search of an institutional neuropathology database and a separate review of current procedural terminology (CPT) codes. Age, sex, clinical presentation, presence of neurofibromatosis (NF), tumor type, tumor location, extent of resection characterized as gross total or subtotal, use of intraoperative neuromonitoring, surgical complications, presence of neurological deficit, and clinical follow-up were recorded. RESULTS Two hundred twenty-one tumors in 199 patients with a mean age of 45 years were identified. Fifty-three tumors were neurofibromas; 163, schwannomas; and 5, malignant peripheral nerve sheath tumors (MPNSTs). There were 70 complications in 221 cases, a rate of 32%, which included 34 new or worsening sensory symptoms (15%), 12 new or worsening motor deficits (5%), 10 CSF leaks or pseudomeningoceles (4%), 11 wound infections (5%), 5 cases of spinal deformity (2%), and 6 others (2 spinal epidural hematomas, 1 nonoperative cranial subdural hematoma, 1 deep venous thrombosis, 1 case of urinary retention, and 1 recurrent laryngeal nerve injury). Complications were more common in cervical (36%) and lumbosacral (38%) tumors than in thoracic (18%) lesions (p = 0.021). Intradural and dumbbell lesions were associated with higher rates of CSF leakage, pseudomeningocele, and wound infection. Complications were present in 18 neurofibromas (34%), 50 schwannomas (31%), and 2 MPNSTs (40%); the differences in frequency were not significant (p = 0.834). Higher complication rates were observed in patients with NF than in patients without (38% vs 30%, p = 0.189), although rates were higher in NF Type 2 than in Type 1 (64% vs 31%). There was no difference in the use of intraoperative neuromonitoring when comparing cases with surgical complications and those without (67% vs 69%, p = 0.797). However, the use of neuromonitoring was associated with a significantly higher rate of gross-total resection (79% vs 66%, p = 0.022). CONCLUSIONS Resection is a safe and effective treatment for spinal nerve sheath tumors. Approximately 30% of patients developed a postoperative complication, most commonly new or worsening sensory deficits. This rate probably represents an inevitable complication of nerve sheath tumor surgery given the intimacy of these lesions with functional neural elements.

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“…Their mean age at diagnosis was 50.9 years with more patients in the higher age group and fty-six percent of patients were male. However, it had no description of the incidence at the sacrum [14]. In our cohort, the analysis of clinical feature of MPNST showed an obvious predilection of female (M: F=0.68:1) and the peak age ranged from 41 to 50 years.…”

Section: Location Distribution Of Sacral Tumors and Tumor-like Lesionsmentioning

confidence: 65%

Clinical characteristics of 1385 sacral tumors and tumor-like lesions not including metastatic cancers in one institution in China

Wang

Yang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Sacral tumors and tumor-like lesions are a rare group of lesions that can affect children and adults of all ages. Little is known about clinical characteristics of age, gender, histologic type and anatomic site in China.Methods: 1385 patients with sacral tumors and tumor-like lesions, which had the clinical record at our bone tumor center from January 2000 to November 2018 were analyzed. The metastatic cancers were not included in the present study.Results: 51.7% (716 cases) were malignant and 48.3 % (669 cases) were benign tumors or tumor-like lesions. Of malignant tumors, chordoma was the most common malignant tumor (316 cases, 22.8% of all tumors), followed by chondrosarcoma, myeloma and other histologic types. The most common histological type of benign tumors was giant cell tumor accounting for 14.8% (205 cases) of all tumors, followed by neurofibroma, schwannoma and other types. The most common age group affected by malignant bone tumors was the 51- to 60-year-old group, followed by the 41- to 50-year-old group. The most commonly affected age group for benign tumors and tumor-like lesions was the 31- to 50-year-old group, followed by the 21- to 30-year old group. Furthermore, the following histologic types had the gender predilection. Chordoma, chondrosarcoma, myeloma and osteosarcoma affected more frequently males than females. Malignant peripheral nerve sheath tumor, lymphoma, giant cell tumor, neurofibroma, tuberculosis, teratoma and epidermoid cyst more frequently affected females than males.Conclusions: The large cohort of sacral tumors and tumor-like lesions in our database may reveal their clinical characteristics of age, gender, histologic type and anatomic site in China and features of sacral tumors and tumor-like lesions is fairly distinct from the mobile spine and extremities.

show abstract

Malignant peripheral nerve sheath tumors of the spine: A SEER database analysis

Cited by 9 publications

References 27 publications

Epidemiological characteristics of 1385 sacral tumors and tumor-like lesions not including metastatic cancers in one institution in China

Epidemiological characteristics of 1385 sacral tumors and tumor-like lesions not including metastatic cancers in one institution in China

Neurological outcomes and surgical complications in 221 spinal nerve sheath tumors

Clinical characteristics of 1385 sacral tumors and tumor-like lesions not including metastatic cancers in one institution in China

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