Malignant peripheral nerve sheath tumours in neurofibromatosis type 1: MRI supports the diagnosis of malignant plexiform neurofibroma

Mautner, Victor‐F.; Friedrich, Reinhard E; Deimling, Andreas von; Hagel, Christian; Korf, Bruce R.; Knöfel, M. T.; Wenzel, Ralph; Fünsterer, C.

doi:10.1007/s00234-003-0964-6

Cited by 99 publications

(47 citation statements)

References 9 publications

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“…MPNSTs classically lack the target sign that is commonly seen in benign neurofibromas. Findings on MRI that are suggestive of malignancy include: increase in the size of previously stable neurofibromas [38], large size [38], inhomogeneity [35], ill-defined margins, invasion of fat planes [33], and perilesional edema [33]. Accurate grading of MPNSTs by MRI criteria is not possible [38].…”

Section: Radiology Of Mpnstmentioning

confidence: 99%

Malignant peripheral nerve sheath tumor: Molecular pathogenesis and current management considerations

Grobmyer¹,

Reith²,

Shahlaee³

et al. 2008

Journal of Surgical Oncology

182

164

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Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are rare tumors that often occur in patients with neurofibromatosis 1. Surgical resection represents the mainstay of treatment. Radiation and chemotherapy have a role in selected patients with MPNST. Accurate pathologic diagnosis remains a challenge in many cases of MPNST. There are many recent advances in the understanding of the molecular pathogenesis of MPNST which represent the best opportunities to develop new strategies for management of patients with MPNST.

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Section: Radiology Of Mpnstmentioning

confidence: 99%

Malignant peripheral nerve sheath tumor: Molecular pathogenesis and current management considerations

Grobmyer¹,

Reith²,

Shahlaee³

et al. 2008

Journal of Surgical Oncology

182

164

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“…Further, MRI has been suggested as a potentially useful tool in detecting progression to malignancy in NF1 neurofibromas. 44 We are currently exploring the use of MRI in studying the malignant progression of neurofibromas, using NF1 xenograft models of both MPNST and plexiform-like neurofibroma.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA Inhibitors as Anticancer Therapies

Hammond¹

2007

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. (From -To) REPORT DATE (DD-MM-YYYY) 01-04-2007 REPORT TYPE Revised Final DATES COVERED PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERUniversity of Florida Gainesville, FL 32610 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACTThe goal of this project is to specify how anti-angiogenic approaches can be effectively applied to NF1 tumors. Invivo and in vitro models were used to firmly conclude that Nf1 haploinsufficiency in endothelial cells results inexaggerated proliferation and angiogenesis in response to key pro-angiogenic factors. Results implicate these growthfactor pathways as potential targets for therapeutic agents. In addition, endostatin was found to be a potent inhibitorof Nf1+/-endothelial cell migration in vitro, suggesting endostatin may be an effective antiangiogenic agent forreducing NF1 tumor growth. Two intraneural xenograft models of NF1 peripheral nerve sheath tumors weredeveloped and characterized. Tumor growth and vascularity of NF1 tumor xenografts was quantified by advancedMRI, gadolinium permeability and dynamic contrast enhancement that match results obtained by conventionalhistological measurements. Several methods to deliver endostatin in vivo were tested and several difficulties wereencountered. Finally, cell factories made by alginate-encapsulation of 293 cells transfected with AAV-endostatinwere developed and are being refined to deliver consistent, high-dose systemic levels of endostatin. The effects ofsystemic endostatin on NF1 xenograft tumor growth will be completed in a no-cost extension of this project. SUBJECT TERMSCancer biology, angiogenesis, xenograft, gene therapy, anti-angiogenic therapy, MRI INTRODUCTIONNeurofibromatosis type 1 (NF1) is a common genetic disease with a wide variety of features which primarily involve the nervous system and related tissues. NF...

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“…Isolated Plexiform Neurofibroma of Arm with Unusual Presentation -A Rare Case Report changes [2,3]. While it is a matter of debate amongst literature, that what is proper time and proper extent of PNF resection.…”

Section: Orthopaedics Sectionmentioning

confidence: 99%

Isolated Plexiform Neurofibroma of Arm with Unusual Presentation - A Rare Case Report

Mishra

Dwivedi

Shrivastava

et al. 2015

JCDR

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Plexiform neurofibroma (PNF) arises as a diffuse mass from nerve trunk and leads to overgrowth of cutis and subcutis structure. This is a case report of 20-year-old male, presented to our hospital with a giant ulcerated swelling over his left arm. Differential diagnosis of sarcoma, neurofibroma, hemangioma and angiolipoma was made but biopsy confirmed the diagnosis of plexiform neurofibroma. Isolated PNF with ulceration of overlying skin over arm is a rare presentation and here we are presenting it as a perusal of rare entity.[Table/ Fig-1

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Malignant peripheral nerve sheath tumours in neurofibromatosis type 1: MRI supports the diagnosis of malignant plexiform neurofibroma

Cited by 99 publications

References 9 publications

Malignant peripheral nerve sheath tumor: Molecular pathogenesis and current management considerations

Malignant peripheral nerve sheath tumor: Molecular pathogenesis and current management considerations

MicroRNA Inhibitors as Anticancer Therapies

Isolated Plexiform Neurofibroma of Arm with Unusual Presentation - A Rare Case Report

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