Malignant priapism as the initial clinical manifestation of metastatic renal cell carcinoma with invasion of both corpora cavernosum and spongiosum

Nezu, Frank M; Dhir, Rajiv; Logan, Theodore F.; Lavelle, John P.; Becich, Michael J.; Chancellor, Michael B.

doi:10.1038/sj.ijir.3900342

Cited by 12 publications

(9 citation statements)

References 2 publications

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“…Priapism, the so-called malignant priapism, 11 , 16 , 20 , 24 , 34 , 44 , 46 , 111 , 123 , 150 is reported with varying frequencies of from 20 to 53%. It is usually associated with a mass or induration of the penis.…”

Section: Discussionmentioning

confidence: 99%

A review of penile metastasis

et al. 2012

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Penile cancer as primary disease is relatively rare in developed countries. The penis is a rare site of metastases in spite of its rich vascularization. Approximately 500 cases have been reported in the literature; almost 70% of primary lesions are of pelvic origin (from genitourinary or recto-sigmoid primary tumors). We describe a case of penile metastasis from lung cancer. The rarity of the event prompted us to also explore related reviews and discuss the incidence, physiopathology, diagnosis and therapy of penile secondary cancer.

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Section: Discussionmentioning

confidence: 99%

A review of penile metastasis

et al. 2012

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“… 2 It has been explained that RCC metastasizing to penis via retrograde venous flow seems a likely etiology despite the spermatic vein do not normally anastomose with the dorsal venous system. 2 , 3 In addition, the primary RCC of this Case contained two components, clear cell RCC and papillary RCC. However, the clear cell RCC, not papillary RCC, metastasized to penis.…”

Section: Discussionmentioning

confidence: 83%

Malignant priapism as the initial presentation induced by the metastasis of renal clear cell carcinoma after radical nephrectomy

Luo

Yang

Cai

et al. 2021

Urology Case Reports

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The priapism secondary to the tumor metastasis to penis is rare. We described a case of a patient with priapism caused by the metastasis of renal cell carcinoma after radical nephrectomy. The previous reported cases found in the literature were reviewed. The pathophysiology, diagnosis, management and prognosis were discussed. Renal cell carcinoma metastasis to penis usually represents a more advanced stage of disease and carries a poor prognosis. The therapy is only palliative.

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“…Synchronous or metachronous RCC metastases typically occur to the brain, lungs, bones, liver, adrenals; atypical location appears to be rare and may involve numerous distant sites [4]. Corpus carvernosum is intended to be an atypical site and is usually synchronous with the primary renal lesion [7], while if it is presented as metachronous, the onset is temporally close to the renal cancer diagnosis [8,9]. mogeneous solid expansive lesion with polylobate profiles of 52 × 58 mm, that originated from the crus of right corpus cavernosum: The mass was placed posteriorly to the base of the penis and strictly related to the internal profile of the right ischiopubic branch with partial compression and dislocation to the left of the anal canal and of the corpus spongiosum of the urethra (Figure 1a and Figure 1b).…”

Section: Discussionmentioning

confidence: 99%

Corpus Cavernosum Atypical Metastasis of Renal Cell Carcinoma: Presurgical Therapy and Complete Surgical Resection. Case Report and Review of the Literature

Saccà¹,

Roscigno²,

Nicolaï³

et al. 2018

Clin Med Rev Case Rep

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Renal-Cell Carcinoma (RCC) accounts for 2% of all cancers. Metastases are present in up to 30% of patients at diagnosis or appeared during follow up [1]. Atypical RCC metastases are sites, other than chest, liver, bone, adrenal, brain, and nodes, and their presentation is very rare. We describe the case of a 71-years-old male, who was submitted to a left laparoscopic radical nephrectomy for Clear Renal Cell Carcinoma (CRCC). After a 14-year follow-up, MRI scan showed a 5-cm solid lesion of the perineum, that originates from the right corpus cavernosum. A percutaneous trans-perineal biopsy revealed an atypical metastasis of CRCC. To reduce surgical risk during the exeresis of the mass, the patient received 4 cycles of pazopanib as presurgical treatment, with a shrinking of the lesion at follow-up MRI scan. He underwent a complete resection of the residual mass. Histopathology confirmed the diagnosis of atypical corpus cavernosum metastasis of CRCC. Presurgical therapy with Target Molecular Therapy (TMT) is feasible and might have several potential advantages for patients in case of complex metastasectomy.

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Malignant priapism as the initial clinical manifestation of metastatic renal cell carcinoma with invasion of both corpora cavernosum and spongiosum

Cited by 12 publications

References 2 publications

A review of penile metastasis

A review of penile metastasis

Malignant priapism as the initial presentation induced by the metastasis of renal clear cell carcinoma after radical nephrectomy

Corpus Cavernosum Atypical Metastasis of Renal Cell Carcinoma: Presurgical Therapy and Complete Surgical Resection. Case Report and Review of the Literature

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