Malignant Struma Ovarii with Thyrotoxicosis

Matsuda, Kyoko; Maehama, Toshiyuki; Kanazawa, Kazuki

doi:10.1006/gyno.2001.6315

Cited by 69 publications

(67 citation statements)

References 8 publications

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“…In literature, most of the data about this condition is collected from individual case reports, case series [1,2,4]. As presented in this case, the majority of cases are incidentally diagnosed [5,[6][7][8][9].…”

Section: Discussionmentioning

confidence: 96%

“…Malignant transformation of struma ovarii is an extremely rare condition [1]. In literature, most of the data about this condition is collected from individual case reports, case series [1,2,4].…”

Section: Discussionmentioning

confidence: 99%

“…Several patients presented with menstrual irregularities (9%), hyperthyroidism (5-8%), ascites (17%), deep vein thrombosis (4%) [2,4]. Only 5-8% of the patients with malignant struma ovarii present with clinical hyperthyroidism [1,3,4]. Intra-operative frozen section samples usually reveal a mature cyctic teratoma or benign thyroid tissue [6].…”

Section: Discussionmentioning

confidence: 99%

“…When thyroid tissue comprises more than 50% of the ovarian teratoma, it is termed ''struma ovarii''. The exact incidence of malignancy in struma ovarii is hard to evaluate, because of its uncommon nature [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…Thyrotoxicosis appears in 5-15% of cases. Ascites (17%) and Meigs' syndrome (5%) can be seen [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

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Follicular Variant of Papillary Thyroid Carcinoma Arising in a Mature Cystic Teratoma of the Ovary

Özay¹,

Özay²,

Acar³

et al. 2016

J Gynecol Res Obstet

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Mature cystic teratomas form approximately 20% of all ovarian tumours. Of these, approximately 15% include benign thyroid tissue. When thyroid tissue comprises more than 50% of the ovarian teratoma, it is termed ''struma ovarii''. The exact incidence of malignancy in struma ovarii is hard to evaluate, because of its uncommon nature. The aim of this study is to report a rare case of follicular variant of papillary thyroid carcinoma arising in mature cystic teratoma of the right ovary. A 43-year-old premenopausal female, gravida 3, para 2 was admitted to Dokuz Eylul University Hospital with an incidental ultrasonographic fi nding of a complex solid echogenic right ovarian mass during her annual gynecological examination. The preoperative diagnosis was dermoid cyst. The patient underwent laparoscopic surgery. At exploration, the left ovary, the left fallopian tube, and the uterus were normal. The right ovary was enlarged, white and smooth ovarian semisolid mass was noted. Histopathologic evalutation revealed a tumor of follicular variant of papillary thyroid carcinoma arising in a mature cystic teratoma. The case was discussed at the multidisciplinary oncology meeting. Postoperatively, the thyroid function tests, thyroid gland sonogram were requested. The results were normal. A total body scanning with I 131 was done. The test revealed no residual intrabdominal/pelvic carcinoma. Total abdominal hysterectomy, bilateral salpingooophorectomy, peritoneal washings, bilateral pelvic-paraaortic lymphadenectomy, partial omentectomy and peritoneal biopsies were performed. In conclusion, the treatment modalities for malignancy in struma ovarii or mature cystic teratoma depend on the stage of the disease and fertility desire.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Thyrotoxicosis appears in 5-15% of cases. Ascites (17%) and Meigs' syndrome (5%) can be seen [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Follicular Variant of Papillary Thyroid Carcinoma Arising in a Mature Cystic Teratoma of the Ovary

Özay¹,

Özay²,

Acar³

et al. 2016

J Gynecol Res Obstet

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A case report of malignant struma ovarii with papillary thyroid carcinoma

Rahimi,

Rabizadeh,

Seifouri

et al. 2024

Clinical Case Reports

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Key clinical messageStruma ovarii (SO), is a rare and specialized ovarian teratoma. The treatment is controversial depending on the risk of recurrence and metastasis. Here a SO with papillary thyroid carcinoma is reported and the approach is thoroughly discussed.AbstractStruma ovarii (SO) is a highly specialized ovarian teratoma primarily composed of thyroid tissue. Clinical features associated with SO include lower abdominal discomfort, unusual vaginal bleeding, ascites, and hyperthyroidism. While SO rarely transforms into malignancy, the optimal degree of treatment remains controversial due to the varying risks of recurrence and metastasis. In this report, we present the case of a 64‐year‐old woman experiencing abdominal pain and diagnosed with SO, accompanied by papillary thyroid carcinoma. We thoroughly discuss the evaluation and management of this rare condition.

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