Malignant transformation and new primary tumours after therapeutic radiation for benign disease: substantial risks in certain tumour prone syndromes

Evans, D. Gareth

doi:10.1136/jmg.2005.036319

Cited by 255 publications

(177 citation statements)

References 79 publications

Supporting

Mentioning

172

Contrasting

Unclassified

Order By: Relevance

“…35,36 It has also been reported that radiation-induced tumors can be easily mistaken for de novo tumors in the context of NF2. 37 Conversely, Rowe et al 38 reported that the risk of secondary malignancy in NF2 patients is not as formidable as previously considered. Because the follow-up period in this study was not long, and many young patients were included, careful observation and reevaluation of the risks are required.…”

Section: Discussionmentioning

confidence: 93%

Radiosurgical treatment of vestibular schwannomas in patients with neurofibromatosis type 2

Phi¹,

Kim²,

Chung³

et al. 2009

Cancer

View full text Add to dashboard Cite

BACKGROUND:The radiosurgical treatment of vestibular schwannomas in patients with neurofibromatosis type 2 (NF2) is controversial. The authors investigated the radiologically proven tumor control rate after gamma knife radiosurgery. The factors that affect tumor control and serviceable hearing preservation were analyzed.METHODS:Thirty‐six lesions in 30 patients were included. The median lengths of the clinical and radiologic follow‐ups were 48.5 months and 36.5 months, respectively. The median tumor volume was 3.2 cm3. The mean marginal dose was 12.1 grays (Gy) (range, 8–14 Gy) at an isodose line of 50%±0.6%. The Kaplan‐Meier method and Cox proportional hazards model were used for the statistical analyses.RESULTS:The actuarial tumor control rate was 81%, 74%, and 66%, respectively, in the first, second, and fifth years. Five tumors required a salvage surgery because of tumor control failure. A low marginal dose and a young age at radiosurgery were associated with poor tumor control. Of the 16 tumors with which ipsilateral hearing was serviceable, the actuarial serviceable hearing preservation rates were 50%, 45%, and 33%, respectively, in the first, second, and fifth years. Better ipsilateral hearing (Gardner‐Robertson grade 1, compared with grade 2) at the time of radiosurgery was associated with significantly greater serviceable hearing preservation.CONCLUSIONS:Gamma knife radiosurgery for vestibular schwannomas in NF2 patients provided 5‐year tumor control in approximately two‐thirds of patients and preserved serviceable hearing in approximately one‐third. The rates of other cranial nerve deficits were low, and no secondary malignancy was observed. Radiosurgery should be included in treatment options for NF2 patients. Cancer 2009. © 2009 American Cancer Society.

show abstract

Section: Discussionmentioning

confidence: 93%

Radiosurgical treatment of vestibular schwannomas in patients with neurofibromatosis type 2

Phi¹,

Kim²,

Chung³

et al. 2009

Cancer

View full text Add to dashboard Cite

show abstract

“…4 Second, malignant transformations have also been re ported, especially in patients with neurofibromatosis Type 2. 8,23 Third, radiotherapy can induce delayed cognitive disorders, especially in elderly patients, resulting in loss of autonomy. 25 As there is still no consensus regarding the ideal management of such tumors, the morbidity resulting from these 2 treatment methods should be taken into ac count during the management of Grade 2 meningiomas.…”

Section: Natural History Of Grade 2 Meningiomamentioning

confidence: 99%

Grade 2 meningioma and radiosurgery

Aboukaïs¹,

Zaïri²,

Lejeune³

et al. 2015

JNS

View full text Add to dashboard Cite

OBJECT World Health Organization Grade 2 meningiomas are aggressive tumors associated with a high recurrence rate leading to repeated surgical procedures, which can seriously worsen a patient's neurological status. Although radiosurgery is an increasingly popular technique, its role in the management of Grade 2 meningiomas has yet to be defined. In this study the authors aimed to evaluate radiosurgery in achieving control of proven tumor progression occurring after resection of Grade 2 meningioma. METHODS This retrospective study included consecutive patients who, between 2000 and 2012, had undergone radiosurgery for radiologically proven progression of a previously surgically treated Grade 2 meningioma. RESULTS Twenty-seven patients were eligible for analysis. There were 9 men and 18 women with a mean age of 59 years. The mean radiation dose was 15.2 Gy (range 12–21 Gy), and the mean target volume was 5.4 cm3 (range 0.194–14.2 cm3). Thirty-four radiosurgical procedures were performed in the 27 patients. The mean progression-free survival after radiosurgery was 32.4 months among those with progression in a target irradiated volume and 26.4 months among those with progression in any intracranial meninges. With a mean follow-up of 56.4 months (range 12–108 months), the 12-, 24-, and 36-month actuarial local control rates for all patients were 75%, 52%, and 40%, respectively, and the regional control rates were 75%, 48%, and 33%. A single case of transient hemiparesis completely resolved without sequelae. CONCLUSIONS Radiosurgery appears to be a safe and effective treatment for the local control of delayed progression after resection of a Grade 2 meningioma. Higher radiation doses similar to those applied for malignant tumors should be recommended when possible.

show abstract

“…4) Malignant transformation of acoustic neurinoma and meningeal melanocytoma after gamma knife surgery have been reported, 7,21,24) but not malignant transformation of chordoma. The malignant transformation in the present case exhibited unique characteristics, and could have been caused by the gamma knife surgery.…”

Section: Discussionmentioning

confidence: 99%

Malignant Transformation of Clival Chordoma After Gamma Knife Surgery -Case Report-

Tsuboi

Hayashi

Kurimoto

et al. 2007

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

A 54-year-old woman presented a midline clival tumor manifesting as right abducens palsy in May 1997. Magnetic resonance (MR) imaging revealed a midline clival tumor. She underwent surgery twice with the transsphenoidal approach and gamma knife surgery for residual tumor. The histological diagnosis was chordoma. MR imaging revealed that the tumor had extended to the right cerebellopontine angle, with spinal seeding in February 2002. She underwent partial removal of the right cerebellopontine angle tumor. The histological diagnosis was chordoma with slight nuclear atypism. She died 5 years and 5 months after the first gamma knife surgery. Autopsy revealed multiple areas of spinal seeding. Histological examination confirmed malignant transformation with unique epithelial characteristics, possibly caused by gamma knife surgery.

show abstract

Malignant transformation and new primary tumours after therapeutic radiation for benign disease: substantial risks in certain tumour prone syndromes

Cited by 255 publications

References 79 publications

Radiosurgical treatment of vestibular schwannomas in patients with neurofibromatosis type 2

Radiosurgical treatment of vestibular schwannomas in patients with neurofibromatosis type 2

Grade 2 meningioma and radiosurgery

Malignant Transformation of Clival Chordoma After Gamma Knife Surgery -Case Report-

Contact Info

Product

Resources

About