Maligne epitheliale Tumoren des Ovars

Petru, Edgar; Moinfar, Farid; Lang, Peter; Winter, Raimund; Tamussino, Karl; Sehouli, Jalid

doi:10.1007/3-540-30015-5_5

Cited by 2 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies suggest that there are high incidence rates of OC in countries with high development index (HDI); similarly HDI countries demonstrate higher prevalence of known OC risk factors including nulliparity/low parity, advanced age, hormone replacement therapy and family predisposition . Increasing life expectancy and a more westernized lifestyle has led to rising numbers in countries with a low development index (LDI) .…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics and Survival of Patients with Malignant Ovarian Tumors in Addis Ababa, Ethiopia

et al. 2019

View full text Add to dashboard Cite

Background Ovarian cancer is the third leading cause of cancer death among women in Ethiopia, with about 2,550 diagnosed cases and 2,000 deaths each year. The incidence and mortality rates of this disease have been increasing in Ethiopia and other parts of sub‐Saharan Africa over the past decades because of changing lifestyle and reproductive factors. In this study, we describe the clinical characteristics, treatment patterns, and survival of patients with ovarian cancer in Ethiopia. Materials and Methods This retrospective cohort study included 485 patients diagnosed between January 2009 and October 2015 at Addis Ababa University Hospital, Zewditu Memorial Hospital, or registered in the Addis Ababa population‐based cancer registry. Follow‐up data were obtained via telephone. Primary endpoint was all‐cause mortality. Results The median age was 46 years (range, 11–95). The estimated 1‐ and 2‐year overall survival rates were 78% (95% confidence interval [CI] 0.741–0.82.5) and 59% (95% CI, 0.538–0.646), respectively. Of those patients with result available (n = 423), 73.0% had epithelial cancers. Almost half were classified as Federation of Gynecology and Oncology stage III or IV (48.2%; stage available n = 201) resulting in worse outcomes (hazard ratio [HR], 2.91 [CI 0.67–12.64] and 3.03 [0.69–15.79], respectively). Four out of five patients received some form of surgery (82%), three out of five received platinum‐containing chemotherapy. Patients with residual tumor after surgery (n = 83) showed worse survival outcome (HR, 2.23; 95% CI 1.08–4.49). Conclusion Our study revealed substantial treatment gaps with respect to surgery and adequate chemotherapy. Higher stage, residual tumor and lack of chemotherapy impaired the outcome. Access to higher standards of ovarian cancer treatment is urgently needed in Ethiopia. Implications for Practice Ovarian cancer is often a fatal disease in high resource settings; now it is also becoming important in Ethiopia. This study included 485 women with malignant ovarian tumors treated in Addis Ababa who had a mean age of only 46 years because of the young population structure. Three quarters had the typical epithelial cancer, with half presenting with advanced stage III and IV. Improved oncologic surgery and sufficient chemotherapy could possibly improve their outcome. The relatively high proportion of women with nonepithelial cancer need adequate treatment options to have good prognosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics and Survival of Patients with Malignant Ovarian Tumors in Addis Ababa, Ethiopia

et al. 2019

View full text Add to dashboard Cite

show abstract

“…When the disease is in its early stage, the mortality rate is much lower than it is as the disease progresses. According to the classification of the International Federation of Gynecology and Obstetrics (FIGO) [ 2 ], in the early stages (FIGO I), there is a relatively high 5-year survival rate of 80–85%, whereas patients diagnosed with very advanced stages (FIGO IIIC and FIGO IV) have a survival rate of just 25% or less [ 3 ]. However, when diagnosed, 75% of patients had advanced epithelial ovarian cancer (FIGO III and FIGO IV), explaining the dismal median 5-year survival rate [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

A Promising Approach for Primary Cytoreductive Surgery for Advanced Ovarian Cancer: Survival Outcomes and Step-by-Step Description of Total Retroperitoneal en-Bloc Resection of Multivisceral-Peritoneal Packet (TROMP)

Muallem

Kluge

Sayasneh

et al. 2022

JPM

View full text Add to dashboard Cite

(1) Background: A complete tumor resection during primary cytoreductive surgery has been reported to be the most important and perhaps the only independent prognostic factor in advanced ovarian cancers. The goal of complete cytoreduction needs to be weighed against the potential morbidities and long-term survival outcomes. (2) Methods: in this retrospective analysis of a prospectively obtained database, 208 consecutive patients with advanced ovarian cancer who underwent a conventional primary cytoreductive surgery (150 patients) or TROMP technique (58 patients) were included. Progression-free and overall survival rates were calculated using Kaplan–Meier analysis as well as the 95% confidence interval of the hazard ratio between treatment groups. (3) Results: After a median follow-up phase of more than 3 years (range 1–72 months), there are no statistically significant differences between both groups in progression-free and overall survival rates. Albeit, the TROMP group included statistically significant more advanced-stage cases compared to the conventional surgery group. (4) Conclusions: the TROMP technique is a promising tool for successful primary cytoreductive surgery in a selected group of patients with high tumor burdens in order to achieve optimal surgical results and survival outcomes without introducing any additional risks or complications.

show abstract

Maligne epitheliale Tumoren des Ovars

Cited by 2 publications

References 18 publications

Clinical Characteristics and Survival of Patients with Malignant Ovarian Tumors in Addis Ababa, Ethiopia

Clinical Characteristics and Survival of Patients with Malignant Ovarian Tumors in Addis Ababa, Ethiopia

A Promising Approach for Primary Cytoreductive Surgery for Advanced Ovarian Cancer: Survival Outcomes and Step-by-Step Description of Total Retroperitoneal en-Bloc Resection of Multivisceral-Peritoneal Packet (TROMP)

Contact Info

Product

Resources

About