Malnutrition is a prognostic factor in patients with hepatocellular carcinoma (HCC)

Schütte, Kerstin; Tippelt, Bernadett; Schulz, Christian; Röhl, Friedrich-Wilhelm; Feneberg, Anja C.; Seidensticker, Ricarda; Arend, Jörg; Malfertheiner, Peter

doi:10.1016/j.clnu.2014.11.007

Cited by 109 publications

(84 citation statements)

References 48 publications

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“…In that study, the results applied to a general population with advanced cancer (breast, gastrointestinal, genitourinary gynecologic, head-and-neck, hematologic, lung, and others). Those authors and the authors of other publications 43 reported about various types of cancer; only a few studies have reported detailed data for single cancer types [30][31][32][33]37,43 : breast cancer, advanced non-small-cell lung cancer, colorectal cancer, hepatocellular carcinoma, and finally, in our study, hnc. In the present prospective study of a homogeneous population with advanced hnc, pa was observed to be as significant a reference test as the sga with respect to overall survival.…”

Section: Discussionmentioning

confidence: 69%

Bioelectrical Impedance Phase Angle as a Prognostic Indicator of Survival in Head-and-Neck Cancer

Wladysiuk

Mlak²,

Morshed

et al. 2016

Current Oncology

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Section: Discussionmentioning

confidence: 69%

Bioelectrical Impedance Phase Angle as a Prognostic Indicator of Survival in Head-and-Neck Cancer

Wladysiuk

Mlak²,

Morshed

et al. 2016

Current Oncology

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“…Albumin also has a variety of well-studied effects, in addition to regulation of plasma colloid osmotic pressure. These include transportation of hormones, fatty acids and drugs, and also antiinflammatory, antioxidant activity and protection against ischemic damage (34)(35)(36)(37)(38)(39)(40)(41)(42), and it may even be involved in TGFβ-mediated growth control (43). Low albumin is associated with enhanced inflammation, whereas albumin therapy in cirrhotic patients can suppress hepatic inflammation (44,45).…”

Section: Discussionmentioning

confidence: 99%

Serum Albumin Levels in Relation to Tumor Parameters in Hepatocellular Carcinoma Patients

Carr

Guerra

2017

Int J Biol Markers

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ORIGINAL RESEARCH ARTICLEFurthermore, albumin values have been used in the 2-parameter albumin-bilirubin (ALBI) quantitative grading system for liver function in HCC, which has in turn been incorporated into several staging systems (21-25). There is thus much recent interest in serum albumin levels in prognostication, mainly as a reflection of liver function in HCC. However, there is also some direct experimental evidence that increased albumin levels can actually suppress HCC cell growth (26,27). Viewed this way, albumin levels may influence prognosis as much by their actions on HCC biology as by their reflection of impaired liver function.In this study, we examined the clinical correlations of serum albumin levels in a large HCC patient cohort with parameters of HCC behavior, and found an inverse relationship between serum albumin levels and HCC aggressiveness. Methods Patient dataWe retrospectively analyzed a prospectively collected database of 4,139 HCC patients, as previously reported (28,29), who had full baseline tumor parameter data, including computed axial tomography (CT) scan information on HCC size, number of tumor nodules and presence of PVT and plasma AFP levels; complete blood counts; routine blood liver function tests (total bilirubin, γ-glutamyl transpeptidase [GGT] and albumin); and patient demographics. Database management conformed to legislation on privacy, and this study conformed to the ethical guidelines of the Declaration of Helsinki. Approval for this retrospective study

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“…31 The study correlated subjective assessment scores as well as phase angle and other BIA measures to the development of malnourishment and determined a cutoff value of 4.8°for the phase angle to be a reliable independent predictor for malnourishment in this patient population. However, the limitations were a small sample size and a lack of correlation with cancer stand age.…”

Section: Evaluation Of Nutritional Status Using Bia Measuresmentioning

confidence: 99%

The value of bioelectrical impedance analysis and phase angle in the evaluation of malnutrition and quality of life in cancer patients—a comprehensive review

Grundmann

Yoon

Williams³

2015

Eur J Clin Nutr

142

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Bioelectrical impedance analysis (BIA) and especially its derived parameter phase angle have been widely used in different populations. The variability of BIA measures has often been cited as a major limitation for its clinical use in evaluating nutritional status and overall health of patients. Cancer patients often present with malnourishment and cachexia, which complicate the course of treatment and affect outcomes. PubMed, CINAHL, EBSCO and Cochrane Library have been searched for relevant publications in English for BIA in cancer patients. Out of 197 total results, 27 original research articles related to BIA measures in cancer patients were included in this review. Studies indicate that the use of BIA and phase angle measures can benefit in the clinical management of cancer patients in multiple ways: in the prevention; diagnosis; prognosis; and outcomes related to treatments that affect nutritional and overall health status. Phase angle and fat-free mass measures were most commonly evaluated and correlated with nutritional status and survival rate. One limitation of BIA measures is the high interpatient variability which requires careful interpretation of results in the context of the individual patient rather than comparison with population data. The BIA and phase angle provide practitioners for the evaluation of nutritional and overall health status in cancer patients with a convenient and non-invasive technique and should be encouraged.

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Malnutrition is a prognostic factor in patients with hepatocellular carcinoma (HCC)

Cited by 109 publications

References 48 publications

Bioelectrical Impedance Phase Angle as a Prognostic Indicator of Survival in Head-and-Neck Cancer

Bioelectrical Impedance Phase Angle as a Prognostic Indicator of Survival in Head-and-Neck Cancer

Serum Albumin Levels in Relation to Tumor Parameters in Hepatocellular Carcinoma Patients

The value of bioelectrical impedance analysis and phase angle in the evaluation of malnutrition and quality of life in cancer patients—a comprehensive review

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