MALT Lymphoma : Recent Advances in Aetiology and Molecular Genetics

Du, Ming‐Qing

doi:10.3960/jslrt.47.31

Cited by 126 publications

(102 citation statements)

References 91 publications

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“…psittaci elementary bodies in the PBMCs were found viable and infectious and capable to grow in vitro and to be isolated from patients with OAMZL [79]. Taken together, the fact that C. psittaci can be isolated and grown in vitro from biological samples of OAL patients, improves the evidence level supporting this bacte-ria-lymphoma association and fulfills the second Koch's postulate hitherto reserved for H. pylori for gastric lymphoma [81].…”

Section: The Role Ofsupporting

confidence: 53%

Role of Chlamydia in the Development of Ocular Adnexal Lymphoma

Contini¹,

Seraceni²,

Maritati³

et al. 2013

JCT

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The aetiology of OAL is undefined, although much attention has been recently focused on determining whether OAL is caused by an autoimmune disorder, chronic antigenic stimulation or both. It is becoming evident that infectious agents underlying chronic eye infection, as Chlamydia, may play a role in ocular lymphomagenesis. The high prevalence of Chlamydophila psittaci in patients with OAL has suggested a potential oncogenic role for its tendency to cause chronic and persistent infections, although it has been documented an evident geographical variability and response to antibiotic treatment. For C. pneumoniae, the findings so far obtained are very limited not only for identification in OAL but also for the specific treatment with antibiotics. The recent molecular and cultural evidence of C. trachomatis in patients with OAL, seems to suggest that also this pathogen may contribute to pathogenesis of such lymphoma. The potential application of bacteria-eradicating therapy at local and systemic level may ultimately result in safer and more efficient therapeutic option for patients affected by these malignancies. Moreover, a close collaboration between experts in ophthalmology, infectious diseases and hematology will help, in the future, to effectively manage this disease. This review attempts to weigh the currently available evidence regarding the role that Chlamydia play in development of OAL and focuses on patients with OAL observed at our Institution.

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Section: The Role Ofsupporting

confidence: 53%

Role of Chlamydia in the Development of Ocular Adnexal Lymphoma

Contini¹,

Seraceni²,

Maritati³

et al. 2013

JCT

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“…13,15 The optimal treatment approach for localized nongastric MALT lymphoma is still evolving. Micro-organisms have been implicated in the pathogenesis of MALT lymphoma arising from some locations, 16 with successful treatment by using antibiotics, most notably doxycycline for orbital MALT lymphomas. [17][18][19] However, the results are still premature to consider it as a primary modality of therapy because durable remission has only been documented in 48% in a cohort of 27 patients treated 19 and that a uniformly high response rate has not been reported by other investigators.…”

Section: Discussionmentioning

confidence: 99%

Long‐term outcome in localized extranodal mucosa‐associated lymphoid tissue lymphomas treated with radiotherapy

Goda

Gospodarowicz

Pintilie

et al. 2010

Cancer

188

126

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BACKGROUND: This study was conducted to evaluate the long-term outcomes in patients with stage IE and IIE mucosa-associated lymphoid tissue (MALT) lymphomas treated with involved field radiotherapy (RT). METHODS: Between 1989 and 2004, 192 patients with stage I and II MALT lymphomas were treated. The report focuses on 167 patients who received RT. The median age of patients was 58 years with a female predominance (2:1). Presenting sites were as follows: orbital adnexa in 71 patients, salivary glands in 28 patients, stomach in 25 patients, thyroid in 21 patients, and other sites in 22 patients. The median dose to nonorbital sites was 30 grays (Gy) (range, 17.5-35 Gy) and was 25 Gy for the orbit (range, 25-35 Gy). The median follow-up was 7.4 years (range, 0.67-16.20 years). RESULTS: Complete response and complete response, unconfirmed (CR/CRu) was noted in 166 (99%) patients. The 10-year recurrence-free rate (RFR) was 76%, the disease-free survival (DFS) rate was 68%, the overall survival (OS) rate was 87%, and the cause-specific survival rate was 98%. According to presenting site, the 10-year RFR was 95% for thyroid, 92% for stomach, 68% for salivary glands, and 67% for orbit. Patients with thyroid and gastric MALTs had better outcome compared with patients with MALTs diagnosed at other sites (P ¼.004). Among those patients who achieved CR, 19% developed disease recurrence (n ¼ 31), chiefly in distant sites or untreated contralateral-paired organs. At the time of disease recurrence, 7 patients (23%) had transformed to diffuse large B-cell lymphoma, 2 of whom died of lymphoma. The 5-year OS rate after treatment failure was 83%. CONCLUSIONS: Patients with localized MALT lymphomas are reported to have excellent clinical outcome after moderate-dose RT, and some are likely cured. In the current study, thyroid and gastric MALTs were found to have significantly less risk of distant recurrence. Despite disease recurrence, the overall survival remains excellent in these patients. Cancer 2010;116:3815-24.

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“…Malt1 gene is localized in a break point of chromosome 18q21 and t(11;18)(q21;q21) generates API2-MALT1 fusion protein, whereas t(14;18)(q32;q21) juxtaposes Malt1 gene to the immunoglobulin locus and upregulates its expression [41,43,44]. Although transient transfection of wild type MALT1 does not significantly activate NF-κB, overexpression of its oncogenic form potently activates NF-κB in vitro [42,45].…”

Section: Cbm Proteins In Antigen Receptor Signalingmentioning

confidence: 99%

NF-κB signaling pathways regulated by CARMA family of scaffold proteins

Blonska¹,

Lin²

2010

Cell Res

176

201

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The NF-κB family of transcription factors plays a crucial role in cell activation, survival and proliferation. Its aberrant activity results in cancer, immunodeficiency or autoimmune disorders. Over the past two decades, tremendous progress has been made in our understanding of the signals that regulate NF-κB activation, especially how scaffold proteins link different receptors to the NF-κB-activating complex, the IκB kinase complex. The growing number of these scaffolds underscores the complexity of the signaling networks in different cell types. In this review, we discuss the role of scaffold molecules in signaling cascades induced by stimulation of antigen receptors, G-protein-coupled receptors and C-type Lectin receptors, resulting in NF-κB activation. Especially, we focus on the family of Caspase recruitment domain (CARD)-containing proteins known as CARMA and their function in activation of NF-κB, as well as the link of these scaffolds to the development of various neoplastic diseases through regulation of NF-κB.

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MALT Lymphoma : Recent Advances in Aetiology and Molecular Genetics

Cited by 126 publications

References 91 publications

Role of Chlamydia in the Development of Ocular Adnexal Lymphoma

Role of Chlamydia in the Development of Ocular Adnexal Lymphoma

Long‐term outcome in localized extranodal mucosa‐associated lymphoid tissue lymphomas treated with radiotherapy

NF-κB signaling pathways regulated by CARMA family of scaffold proteins

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