Maltodextrin: A Novel Excipient Used in Sugar-Based Orally Disintegrating Tablets and Phase Transition Process

Abstract

Abstract. The recent challenge in orally disintegrating tablets (ODT) manufacturing encompasses the compromise between instantaneous disintegration, sufficient hardness, and standard processing equipment. The current investigation constitutes one attempt to fulfill this challenge. Maltodextrin, in the present work, was utilized as a novel excipient to prepare ODT of meclizine. Tablets were prepared by both direct compression and wet granulation techniques. The effect of maltodextrin concentrations on ODT characteristics-manifested as hardness and disintegration time-was studied. The effect of conditioning (40°C and 75% relative humidity) as a post-compression treatment on ODT characteristics was also assessed. Furthermore, maltodextrin-pronounced hardening effect was investigated using differential scanning calorimetry (DSC) and X-ray analysis. Results revealed that in both techniques, rapid disintegration (30-40 s) would be achieved on the cost of tablet hardness (about 1 kg). Postcompression conditioning of tablets resulted in an increase in hardness (3 kg), while keeping rapid disintegration (30-40 s) according to guidance of the FDA for ODT. However, direct compressionconditioning technique exhibited drawbacks of long conditioning time and appearance of the so-called patch effect. These problems were, yet, absent in wet granulation-conditioning technique. DSC and X-ray analysis suggested involvement of glass-elastic deformation in maltodextrin hardening effect. Highperformance liquid chromatography analysis of meclizine ODT suggested no degradation of the drug by the applied conditions of temperature and humidity. Overall results proposed that maltodextrin is a promising saccharide for production of ODT with accepted hardness-disintegration time compromise, utilizing standard processing equipment and phenomena of phase transition.

The Use of D‐Optimal Mixture Design in Optimizing Development of Okara Tablet Formulation as a Dietary Supplement

“…Maltodextrin, which is usually used as binder in tableting, has also a large effect on the hardness of the tablet. Maltodextrin can absorb and desorb moisture easily from the humidity due to its natural behavior as an amorphous sugar [18]. That explains how the binder provides cohesiveness within the powders in tablet formulation [19].…”

Polycaprolactone/maltodextrin nanocarrier for intracellular drug delivery: formulation, uptake mechanism, internalization kinetics, and subcellular localization

“…This peak was absent in the lyophilized nanoformulation due to the loss of bound water upon drying, as suggested by previous studies. 18,[46][47][48] Nanocarrier internalization and subsequent release of encapsulated product presents a major advantage in the delivery of small molecules where low solubility tends to limit …”

Effect of Combination of Superdisintegrants on the Dissolution Rate: Meclizine Hydrochloride Fast Dissolving Tablets

“…In the present study, fast dissolving tablets were prepared by direct compression method and studied the effect of v superdisintegrants and their concentration on the dissolution rate of MCZ. Some of the recent research examples on MCZ dosage forms are Meclizine hydro chloride mouth dissolving tablets (Nimisha Cyclodextrin-meclizine HCl Inclusion Co and Vasudevan, 2012), Metabolism and pharmacokinetics of meclizine suspension (Wang HCl orally disintegrating tablets (Mahrous Meclazine-maltodextrin oro-dissolving tablets (Elnaggar al., 2010).…”