Maltodextrin-modified graphene oxide for improved enantiomeric separation of six basic chiral drugs by open-tubular capillary electrochromatography

Ma, Mingxuan; Xi, Ying; Du, Yingxiang; Yang, Jiangxia; Ma, Xiaofei; Cheng, Chen

doi:10.1007/s00604-019-4037-x

Cited by 23 publications

(12 citation statements)

References 37 publications

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“…used maltodextrin to modify GO and the chiral product was used as chiral stationary phase in open‐tubular capillary electrochromatography for chiral separation of six chiral drugs, i.e., nefopam, amlodipine, citalopram hydrobromide, econazole, ketoconazole, and cetirizine hydrochloride. [ 123 ] Compared with the pristine silica capillary, the resolution outcomes using the silica capillary after chiral modification were markedly improved. In order to bioimage prostate cancer cells, Mirabello and co‐workers prepared GO/chiral naphthalenediimide chiral nanohybrids, which showed promising applications in biosensing and bioimaging fields.…”

Section: Construction Of Chiral Graphene Hybrid Materialsmentioning

confidence: 99%

“…Maltodextrin‐modified GO was coated on electrochromatographic capillary, on which chiral drugs including nefopam, amlodipine, citalopram hydrobromide, econazole, ketoconazole, and cetirizine hydrochloride were separated. [ 123 ] Compared with the pristine column, the modified one significantly improved the enantiomeric separation of the six racemic drugs. Separation experiments showed that the concentration of chiral selector, concentration of GO, buffer pH, applied voltage, and concentration of buffer all exerted influence on separation process.…”

Section: Chiral Applications Of Chiral Graphene Hybrid Materialsmentioning

confidence: 99%

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Chiral Graphene Hybrid Materials: Structures, Properties, and Chiral Applications

et al. 2021

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Chirality has become an important research subject. The research areas associated with chirality are under substantial development. Meanwhile, graphene is a rapidly growing star material and has hard‐wired into diverse disciplines. Rational combination of graphene and chirality undoubtedly creates unprecedented functional materials and may also lead to great findings. This hypothesis has been clearly justified by the sizable number of studies. Unfortunately, there has not been any previous review paper summarizing the scattered studies and advancements on this topic so far. This overview paper attempts to review the progress made in chiral materials developed from graphene and their derivatives, with the hope of providing a systemic knowledge about the construction of chiral graphenes and chiral applications thereof. Recently emerging directions, existing challenges, and future perspectives are also presented. It is hoped this paper will arouse more interest and promote further faster progress in these significant research areas.

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Section: Construction Of Chiral Graphene Hybrid Materialsmentioning

confidence: 99%

Section: Chiral Applications Of Chiral Graphene Hybrid Materialsmentioning

confidence: 99%

Chiral Graphene Hybrid Materials: Structures, Properties, and Chiral Applications

et al. 2021

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“…Hence, chiral selectors play an important role in chiral separation. At present, several types of compounds have been exploited as chiral selectors, including cyclodextrins and their derivatives, [4][5][6] antibiotics, proteins, 7,8 oligosaccharides [9][10][11] and polysaccharides, [12][13][14] crown ethers, 15,16 surfactants 17 and so on. Since the first antibiotic chiral selector (vancomycin) 18 was utilized for chiral separation in 1994, a variety of antibiotics have been successively reported, including glycopeptides, 19,20 ansamycins, 21,22 macrolides, 23,24 aminoglycosides, 25,26 tetra-cyclines, 27 lincosamides, 28,29 β-lactams 30 and steroid antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of kasugamycin as a chiral selector in capillary electrophoresis

Yi-feng

Cai

2023

Analyst

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“…However, due to the limited amount of stationary phase coating, the OT-CEC also suffers from some problems of relatively poor phase ratio and sample capacity, which results in the low separation capability of OT-CEC. To solve these problems and improve the separation effectiveness of the OT-CEC, some materials have been developed to increase the surface area of OT columns, such as metal-organic frameworks [10,11], carbon nanomaterial [12][13][14], gold nanoparticles [15,16] and covalent organic frameworks (COFs) [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

β‐Cyclodextrin covalent organic framework supported by polydopamine as stationary phases for electrochromatographic enantioseparation

Guan

Huang

et al. 2022

Electrophoresis

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In this work, a new open‐tubular capillary electrochromatography (OT‐CEC) column was prepared using β‐cyclodextrin covalent organic framework (β‐CD COF) as a stationary phase. Polydopamine was used to assist fabrication of β‐CD COF on an inner wall of a fused‐silica capillary. The coating layer on the capillary was characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). Electroosmotic flow (EOF) was also studied to evaluate the variation of the inner wall of immobilized columns. Furthermore, the chiral separation effectiveness of the fabricated capillary column was evaluated by CEC using enantiomers of several related proton pump inhibitors as model analytes, including omeprazole, lansoprazole, pantoprazole and tenatoprazole. The effects of bonding time and concentration of β‐CD COF, the type, concentration and pH of buffer, applied voltage were investigated to obtain satisfactory enantioselectivity. In the optimum conditions, the enantiomers of four analytes were resolved within 15 min with resolutions of 1.63–2.62. The relative standard deviation values for migration times and resolutions of the analytes representing intraday and interday were less than 6.75% and 4.24%, respectively. The results reveal that β‐CD COF has great potential as chiral‐stationary phases for enantioseparation in CEC.

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Maltodextrin-modified graphene oxide for improved enantiomeric separation of six basic chiral drugs by open-tubular capillary electrochromatography

Cited by 23 publications

References 37 publications

Chiral Graphene Hybrid Materials: Structures, Properties, and Chiral Applications

Chiral Graphene Hybrid Materials: Structures, Properties, and Chiral Applications

Evaluation of kasugamycin as a chiral selector in capillary electrophoresis

β‐Cyclodextrin covalent organic framework supported by polydopamine as stationary phases for electrochromatographic enantioseparation

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