Malversation in hair analyses

Flynn, Arthur; Rb, Fratianne; Oa, Hill; Wj, Pories; Wh, Strain

doi:10.1093/ajcn/24.8.893-a

Cited by 14 publications

(8 citation statements)

References 5 publications

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“…Zinc levels in human hair had been the subject of several reports [3,23,28,35,42,46] and comments [8,22,53] since the first documentation of low levels of zinc in hair of humans who were zinc deficient [48]; the potential advantages of this tissue as an index of the nutritional status of zinc have been re-emphasized recently [53], together with some of the problems in interpretation. The possible contribution of the external environment to zinc in hair content after adequate sample washing procedures has been controversial [2,22,35,53].…”

Section: Discussionmentioning

confidence: 99%

Low Levels of Zinc in Hair, Anorexia, Poor Growth, and Hypogeusia in Children

Km¹,

Hambidge²,

Jacobs³

et al. 1972

Pediatr Res

579

168

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ExtractConcentrations of zinc in hair were determined for 338 apparently normal subjects living in Denver with ages ranging from 0-40 years. Mean concentrations of zinc in hair were: neonates (25) 174 db 8 (1 SEM); 3 months^-years (93) 88 ± 5; 4-17 years (132) 153 ± 5, and 17^0 years (88) 180 ±4. Ten children more than 4 years of age had levels of zinc in hair of less than 70 ppm. Seven of these ten children had a history of poor appetite and eight had heights on or below the 10th percentile; the high incidence of low growth percentiles was not explicable on a familial basis. Taste acuity was tested in six of these children, and five had evidence of obj ective hypogeusia. After supplementing the diet with small quantities of zinc, taste acuity was normalized in each of these children and levels of zinc in hair increased. Speculation

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Section: Discussionmentioning

confidence: 99%

Low Levels of Zinc in Hair, Anorexia, Poor Growth, and Hypogeusia in Children

Km¹,

Hambidge²,

Jacobs³

et al. 1972

Pediatr Res

579

168

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“…The use of scalp hair has the advantage of non -invasiveness, ease of collection, preservation (needing no refrigeration) and transport (including air mail postage to distant specialised laboratories), ease of samples once the correct reagent is used, and lack of matrix effect when standard solutions are also prepared in the solubilising fluid (19). Besides, zinc hair determination does not suffer from haemolysis, as happens in serum zinc determinations.…”

Section: N=20mentioning

confidence: 99%

“…The disadvantage of using hair zinc has been attributed to its contamination with greasy products that are normally applied to head hair, and the care that is needed in sampling hair samples. Hair samples must be taken nearer the scalp to reflect the true chronic status of zinc and must be washed repeatedly with different types of solvents to get rid of all possible contaminants (19). These precautions were taken in the present work.…”

Section: N=20mentioning

confidence: 99%

Hair zinc status and its correlation with height indicator in pre-school and school children from a mixed income, low density (mild) community in southern Ghana

Takyi¹

2004

E Af Med Jrnl

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stainless steel stadiometer. The socioeconomic status of the children was also assessed using pretested, weighted and structured questionnaires. Results: The chronic zinc nutritional status was generally good. Out of 344 pupils, 72% (248/344) had adequate status, while 11% were zinc deficient and 9.5% marginally deficient. Excess zinc status was found in 7.5% (26/344) of the children. It appears that growth stunting was not associated with zinc deficiency neither was zinc status affected by the socioeconomic status of the children's families. Conclusion: Nutritional education should be mounted to families of children with deficient, marginally-deficient and excess zinc status and to encourage those with adequate status to maintain their zinc status.

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“…Scalp hair has been increasingly used as a bio-monitor for many elements, both toxic and essential, towards assessing environmental exposures and body nutritional status, as well as diagnosis of diseases (Hammer et al, 1971;Flynn et al, 1971;Krishna et al, 1987;Klevay et al, 1987;Ohmori et al, 1989;Ahmed et al, 1990;Wang et al, 1990;Ashraf et al, 1995a;MacPherson and Basco, 2000;Hintz, 2001). Hair trace metal analysis has many advantages over the more conventional kinds of biological matrices such as blood and urine, primarily because of the ease of sample collection, transport and storage.…”

Section: Introductionmentioning

confidence: 99%

Comparative Metal Distribution in Hair of Pakistani and Libyan Population and Source Identification by Multivariate Analysis

Shah

Shaheen

Khalique

et al. 2006

Environ Monit Assess

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Using nitric acid-perchloric acid wet digestion based FAAS method ten selected metals (Cd, Co, Cr, Fe, K, Mn, Na, Ni, Pb and Zn) were determined in the scalp hair of male Pakistani and Libyan donors (n = 62), between 3-54 years age and residing in typical urban areas. The study was taken up to identify sources of metal distribution in two diverse population segments exposed to different environments. Sodium emerged with the highest mean hair concentration of 511.0 microg/g and 496.9 mug/g for Libyan and Pakistani donors respectively, followed by K, at 266.2 microg/g and 242.4 microg/g for the two donor categories. Cadmium showed the lowest mean hair concentration for both Pakistani (0.380 microg/g) and Libyan (0.530 microg/g) donors. Levels of Na, K, Pb, Cr and Cd were higher in hair of Libyan donors compared with Pakistani counterparts which showed higher comparative levels of Zn, Fe, Co, Ni and Mn. Strong metal-to-metal correlations were found between Na-K (r = 0.638) and Cd-Co (r = 0.574) for Pakistani donors, while for Libyan donors, Na-K (r = 0.680) and Fe-Mn (r = 0.624) correlations emerged as strongly significant. Only K was found to have a strong positive correlation (r = 0.611) with age for Pakistani donors while this correlation was significantly negative (r = -0.500) for Libyan donors, probably arising from individual food habits. Other metals showed no viable relationship with age. Principal Component Analysis (PCA) and Cluster Analysis (CA) of the data evidenced food, industrial emissions and automobile emissions as possible sources of metal distribution. The results of the present study are compared with those reported for subjects from other regions of the world.

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Malversation in hair analyses

Cited by 14 publications

References 5 publications

Low Levels of Zinc in Hair, Anorexia, Poor Growth, and Hypogeusia in Children

Low Levels of Zinc in Hair, Anorexia, Poor Growth, and Hypogeusia in Children

Hair zinc status and its correlation with height indicator in pre-school and school children from a mixed income, low density (mild) community in southern Ghana

Comparative Metal Distribution in Hair of Pakistani and Libyan Population and Source Identification by Multivariate Analysis

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