Mammalian Cell Surface Imaging with Nitrile-Functionalized Nanoprobes:  Biophysical Characterization of Aggregation and Polarization Anisotropy in SERS Imaging

Hu, Qingyan; Tay, Li‐Lin; Noestheden, Matthew; Pezacki, John Paul

doi:10.1021/ja0670005

Cited by 117 publications

(82 citation statements)

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“…SERS is actually sensitive enough to detect even a single biological Brought to you by | MIT Libraries Authenticated Download Date | 5/9/18 6:58 PM molecule without labeling [23,24,83]. There are several geometries to obtain active "surfaces" for SERS, such as the surface of a thin metal film [78], patterned surfaces with nanometer-sized roughness [84,85], metal-coated tip of an atomic force microscopy (AFM) probe [86,87], or nanoparticles [88][89][90][91].…”

Section: Enhancement Of Far-field Raman Scatteringmentioning

confidence: 99%

“…On the contrary, nanoparticles have the ability not only to target cell membrane but also to penetrate through it or get endocytose in intracellular vacuoles. SERS has been reportedly used in imaging cells by targeting cell surfaces with Raman-active molecules conjugated with metal nanoparticles [89] and also to detect cancer cell markers, such as Her2, at cell surface [90]. It has also been used in intracellular imaging of live cell cytosol using gold nanoparticle conjugated with SERS reporter [91].…”

Section: Enhancement Of Far-field Raman Scatteringmentioning

confidence: 99%

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Nonlinear plasmonic imaging techniques and their biological applications

et al. 2016

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Nonlinear optics, when combined with microscopy, is known to provide advantages including novel contrast, deep tissue observation, and minimal invasiveness. In addition, special nonlinearities, such as switch on/off and saturation, can enhance the spatial resolution below the diffraction limit, revolutionizing the field of optical microscopy. These nonlinear imaging techniques are extremely useful for biological studies on various scales from molecules to cells to tissues. Nevertheless, in most cases, nonlinear optical interaction requires strong illumination, typically at least gigawatts per square centimeter intensity. Such strong illumination can cause significant phototoxicity or even photodamage to fragile biological samples. Therefore, it is highly desirable to find mechanisms that allow the reduction of illumination intensity. Surface plasmon, which is the collective oscillation of electrons in metal under light excitation, is capable of significantly enhancing the local field around the metal nanostructures and thus boosting up the efficiency of nonlinear optical interactions of the surrounding materials or of the metal itself. In this mini-review, we discuss the recent progress of plasmonics in nonlinear optical microscopy with a special focus on biological applications. The advancement of nonlinear imaging modalities (including incoherent/ coherent Raman scattering, two/three-photon luminescence, and second/third harmonic generations that have been amalgamated with plasmonics), as well as the novel subdiffraction limit imaging techniques based on nonlinear behaviors of plasmonic scattering, is addressed.

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Section: Enhancement Of Far-field Raman Scatteringmentioning

confidence: 99%

Section: Enhancement Of Far-field Raman Scatteringmentioning

confidence: 99%

Nonlinear plasmonic imaging techniques and their biological applications

et al. 2016

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“…Amino acid functionalized NPs tend to be water-soluble and stable, [21][22][23] and short chain peptides can be used to target a wide range of biological markers. 24 A single molecule monolayer approach has been reported recently 25 and the use of DTSP functionalized NPs as biosensors has also been explored.…”

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confidence: 99%

Development of nanoparticle probes for multiplex SERS imaging of cell surface proteins

et al. 2010

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“…4 Surface plasmon resonances of noble metal nanoparticles produce intense electromagnetic fields particularly at the interstitial sites of the nanostructures, enhancing the Raman scattering of molecules residing at the place. 5 Therefore, arranging nanostructures in close distances in a controlled fashion is a key to producing SERS.…”

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confidence: 99%

Influence of Surface Funcitionalities of Self-Assembled Monolayers on the Adsorption of Gold Nanoparticles

2009

Bulletin of the Korean Chemical Society

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Mammalian Cell Surface Imaging with Nitrile-Functionalized Nanoprobes: Biophysical Characterization of Aggregation and Polarization Anisotropy in SERS Imaging

Cited by 117 publications

References 19 publications

Nonlinear plasmonic imaging techniques and their biological applications

Nonlinear plasmonic imaging techniques and their biological applications

Development of nanoparticle probes for multiplex SERS imaging of cell surface proteins

Influence of Surface Funcitionalities of Self-Assembled Monolayers on the Adsorption of Gold Nanoparticles

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