Mammographic changes in postmenopausal women on hormonal replacement therapy

Abstract

Abstract.the extent was to investigate the effects of hormonal replacement on in postmenopausal women. In a hospital-based study examinations of 81 women were evaluated retrospectively, before and af ter 1-2 years of treatment with oestrogens or a com bination of oestrogens and progestagens. Each indi vidual mammographie film was examined separately, and the glandular tissue was classified according to a a screening-centrebased study two consecutive mammograms, with a 2-year interval, of 645 women, of whom 70 were using some kind of hormone therapy, were evaluated retro spectively. In the hospital-based study 31 % of pa tients treated with combination H R T showed an increase m tibroglandular tissue 8.7 % in the group treated with oestrogens alone.was statistically significant {p = 0.046). In the screening-based study 14.3 % of the wo men using hormonal therapy showed an increase, whereas in the non-users no increase was found (p = 1.24 x 10~l°). After beginning H R T many women (between 14 and 25 % in our experience) can be exincrease in be aware of the aetiology of such changes, and can obtain information on H R T most conveniently by

Changes in magnetic resonance mammography due to hormone replacement therapy

“…Even the specificity of mammography seems to be reduced with postmenopausal HRT [11]. There are differences between women using combination HRT compared with women treated with estrogens alone [12]. …”

Breast density in women with premature ovarian failure or postmenopausal women using hormone therapy: analytical cross-sectional study

“…This study does not enable conclusions to be reached regarding the causes of this finding, but one hypothesis may be that the hypoestrogenism following gonad failure, which would cause regression of fibroglandular tissue and its progressive replacement by fatty tissue, 18,20 may have greater repercussions in reducing breast density when present at a younger age.…”

“…8 Hormone therapy is known to increase the density of the breast parenchyma. However, this does not occur in the majority of women, 18,20,22,28 and this stimulus is also known to vary according to the type of hormone therapy used. In view of these factors, the groups were matched for duration of HT use and for the type of hormone used (CEE + MPA), Nonetheless, matching for exclusively cyclic or continuous use was not possible, since younger women with POF often want to menstruate, whereas postmenopausal women prefer continuous regimes in order to avoid bleeding.…”

“…[13][14][15][16][17] Much information linking HT and breast density in postmenopausal women has been published in the literature. 7,[18][19][20][21][22][23] However, to the best of our knowledge, no papers evaluating the breast density of women with POF have been published, even though these women are frequently treated with HT in the same way as postmenopausal women.…”

Postmenopausal Hormone Replacement Therapy: Endometrial and Breast Effects

“…46 Human studies are sparse, 47,48 and the evidence of increased glandular tissue is mostly indirect, using increased mammographic density as an indicator. [49][50][51] Mammographic density is increased in 11% to 73% of HRT users compared with nonusers or with pretreatment films of users. Increases in density mostly occurred within the first year and were higher with the use of CHRT than with ERT.…”