Mammoth 2.0: will genome engineering resurrect extinct species?

Shapiro, Beth

doi:10.1186/s13059-015-0800-4

Cited by 58 publications

(32 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Eine Alternative ist, die ausgestorbene DNA mit der DNA ihrer nächsten lebenden Verwandten, im Beispiel des Mammuts die der Elefanten, zu verbinden und so beschädigte Elemente zu reparieren oder zu umgehen. Das Genom wird dann aber nicht mehr das gleiche sein, das es vor Millionen von Jahren war, und bisher weiß niemand, ob dieser Ansatz lebensfähige Organismen hervorbringen wird .…”

Section: Abbunclassified

“…Sollte es möglich sein, mehrere Individuen einer Art zu klonen, die auch fortpflanzungsfähig sind, so muss es zumindest zu Beginn eine sichere und nährstoffreiche Umgebung geben – also wahrscheinlich Gefangenschaft. Niemand weiß zudem, wie sich eine gesamte Spezies, die in Gefangenschaft künstlich geschaffen wurde, entwickeln wird und wie genau die natürlichen Verhaltensweisen dieser Tiere aussehen .…”

Section: Abbunclassified

See 1 more Smart Citation

Wird es möglich sein, ausgestorbene Arten wiederzubeleben?

Dänzer¹

2019

Chemie in nserer Zeit

View full text Add to dashboard Cite

show abstract

Section: Abbunclassified

Wird es möglich sein, ausgestorbene Arten wiederzubeleben?

Dänzer¹

2019

Chemie in nserer Zeit

View full text Add to dashboard Cite

show abstract

“…Even if cloning is managed properly, it may expand the genetic pool, can help us bring back genetic materials from dead animals, infertile animals, and even young animals that were too immature to breed [81]. For those extinct organisms for which no living cell exists, cloning is impossible; however, genome editing is the only means to bring extinct species or more accurately extinct traits back to life [82]. …”

Section: Future Hope From Advance Genomicsmentioning

confidence: 99%

Overview on the Role of Advance Genomics in Conservation Biology of Endangered Species

Khan

Nabi

Yousaf

et al. 2016

International Journal of Genomics

View full text Add to dashboard Cite

In the recent era, due to tremendous advancement in industrialization, pollution and other anthropogenic activities have created a serious scenario for biota survival. It has been reported that present biota is entering a “sixth” mass extinction, because of chronic exposure to anthropogenic activities. Various ex situ and in situ measures have been adopted for conservation of threatened and endangered plants and animal species; however, these have been limited due to various discrepancies associated with them. Current advancement in molecular technologies, especially, genomics, is playing a very crucial role in biodiversity conservation. Advance genomics helps in identifying the segments of genome responsible for adaptation. It can also improve our understanding about microevolution through a better understanding of selection, mutation, assertive matting, and recombination. Advance genomics helps in identifying genes that are essential for fitness and ultimately for developing modern and fast monitoring tools for endangered biodiversity. This review article focuses on the applications of advanced genomics mainly demographic, adaptive genetic variations, inbreeding, hybridization and introgression, and disease susceptibilities, in the conservation of threatened biota. In short, it provides the fundamentals for novice readers and advancement in genomics for the experts working for the conservation of endangered plant and animal species.

show abstract

“…Using CRISPR/Cas9 it is possible to make genome modifications in fertilized animal eggs or embryos altering the genetic makeup of every cell in an organism so that changes will be passed to following generations [5]. Another idea, which may encounter acceptation, is to recover extinct species [6]. Also, crops for human consumption may be improved with pest and disease resistant or better nutritional and other consumer qualities, with the advantage that by using CRISPR/Cas9 it is expected that the absence of foreign DNA in the final product and the introduction of genes derived from the same plant species should increase consumer acceptance [7].…”

Section: Introductionmentioning

confidence: 99%

Ethical Issues in Genome Editing for Non-Human Organisms Using CRISPR/ Cas9 System

Rodríguez¹

2017

J Clin Res Bioeth

View full text Add to dashboard Cite

Ethical issues in relation with genome editing for non-human organisms using CRISPR/Cas9 were reviewed. CRISPR/Cas9 system gives rise to significant ethical questions due to its accessibility; ability to make small, precise and specific edits of DNA in living cells; the ability of not leaving trace so that it is not possible to know whether the change has been introduced intentionally or through natural mutation; low cost; speed of use to produce results; and potential to achieve multiple simultaneous edits. The following issues were identified: risks of inducing mutations, the possibility of ecological disequilibrium for edited organisms release in the environment particularly in relation to gene drives, gaps in regulation, animal welfare, military or terrorist applications and the possibility of xenotransplantation between animals and humans. Bioethical issues are also discussed according to principles and about the relation with Nature. The following is recommended: public engagement and ethical reflection are needed to inform decision making; safety issues and environmental risk assessment must be enhanced to ensure efficacious regulation and preventions must be taken to oversee laboratories that use CRISPR technology.

show abstract

Mammoth 2.0: will genome engineering resurrect extinct species?

Abstract: It is impossible to ‘clone’ species for which no living cells exist. Genome editing may therefore provide the only means to bring extinct species — or, more accurately, extinct traits — back to life.

Cited by 58 publications

References 12 publications

Wird es möglich sein, ausgestorbene Arten wiederzubeleben?

Wird es möglich sein, ausgestorbene Arten wiederzubeleben?

Overview on the Role of Advance Genomics in Conservation Biology of Endangered Species

Ethical Issues in Genome Editing for Non-Human Organisms Using CRISPR/ Cas9 System

Contact Info

Product

Resources

About