Man in the Ocean Environment: Physiological Factors

Shilling, Charles W.; Werts, Margaret F.; Schandelmeier, Nancy R.

doi:10.1007/978-1-4684-2154-5_4

The Underwater Handbook 1976

DOI: 10.1007/978-1-4684-2154-5_4

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Man in the Ocean Environment: Physiological Factors

Charles W. Shilling

Margaret F. Werts

Nancy R. Schandelmeier

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1983

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Tissue Distribution of Thiopental and Diazepam in Rats at 71 Atmospheres Pressure

Aanderud

Thoner

1983

Acta Anaesthesiol Scand

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35S-thiopental 15 mg/kg and 14C-diazepam 5 mg/kg were injected intravenously in separate groups of rats (n = 6) at 1 ATA air and at 71 ATA air-He. Total radioactivity was measured in the brain, liver, kidney, muscle and fat after 1, 3, 5 and 15 min. The thiopental content was significantly reduced at pressure in the brain at 3, 5 and 15 min. The diazepam content of the brain was significantly reduced at pressure at 1, 5 and 15 min. The liver, muscle and kidney tissue generally contained slightly less of either drug at pressure, particularly at the earliest sampling times.

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Tissue Distribution of Thiopental and Diazepam in Rats at 71 Atmospheres Pressure

Aanderud

Thoner

1983

Acta Anaesthesiol Scand

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show abstract

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Man in the Ocean Environment: Physiological Factors

Cited by 1 publication

References 132 publications

Tissue Distribution of Thiopental and Diazepam in Rats at 71 Atmospheres Pressure

Tissue Distribution of Thiopental and Diazepam in Rats at 71 Atmospheres Pressure

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