Management and outcomes of severe childhood tuberculosis in the pediatric intensive care setting: can we identify best practices?

Velizarova, Svetlana; Gabrovska, Natalia; Spasova, Albena; Marais, Ben J; Harausz, Elizabeth; Tiberi, Simon; Migliori, Giovanni Battista; Manissero, Davide

doi:10.1590/1806-3713/e20190043

Cited by 5 publications

(4 citation statements)

References 19 publications

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“…6 Currently, in areas with high numbers of new cases, TB is among the top ten diseases responsible for the death of children under five years old. 7 In most cases, a child suspected of having TB is when they have a recurrent respiratory illness. A study carried out in 2018 indicated that approximately 32,000 children worldwidely has MDR-TB every year, and these cases are even more neglected in terms of diagnosis and treatment.…”

Section: Introductionmentioning

confidence: 99%

Obstacles in combating multidrug resistant tuberculosis in pediatric patients: a scope review

Sobreira,

Freitas,

Nascimento

et al. 2024

Rev. Bras. Saude Mater. Infant.

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Objectives: to identify the scientific evidence on excessively resistant and multidrug resistant tuberculosis in pediatric patients. Methods: this is a scope review of the literature, with a guiding question: “What is the scientific evidence on multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis in pediatric patients?”. The research used the descriptors: “extensively drug-resistant tuberculosis” OR “multidrug-resistant tuberculosis” AND “pediatrics”. The research was carried out in a double-blind manner in the following databases of the Medical Literature Analysis and Retrieval System Online, Regional Office for the Western Pacific’s Institutional Repository for Information Sharing, Embase/Elsevier and International Clinical Trials Registry Platform, with a temporal cut-off from 2011 to 2021, sending a final synthesized sample of 18 articles, which evaluated the methodological content through the level of evidence. Results: the results show the lack of research with a high level of evidence related to MDR-TB in children, the lack of adequate dosage of second-line drugs for the pediatric population and the importance of drug sensitivity testing for the cases of treatment Conclusions: it was identified that the obstacles to MDR-TB treatment were concentrated in the lack of detailed protocols, safe drug dosages with a low side effect, and mainly in the social health determinants and disease process involving MDR-TB.

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Section: Introductionmentioning

confidence: 99%

Obstacles in combating multidrug resistant tuberculosis in pediatric patients: a scope review

Sobreira,

Freitas,

Nascimento

et al. 2024

Rev. Bras. Saude Mater. Infant.

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“…6 Atualmente, em áreas com elevados números de novos casos, a TB está entre as dez principais doenças responsáveis pelo óbito de menores de cinco anos. 7 Suspeita-se que uma criança está com tuberculose, na maioria dos casos, quando ela apresenta uma doença respiratória de repetição. Estudo realizado em 2018 aponta que aproximadamente 32.000 crianças adoecem anualmente em todo o mundo por TB-MDR, sendo esses casos ainda mais negligenciados no que se refere ao diagnóstico e tratamento.…”

Section: Introductionunclassified

Obstáculos no combate à tuberculose multidroga resistente em pacientes pediátricos: uma revisão de escopo

Sobreira,

Freitas,

Nascimento

et al. 2024

Rev. Bras. Saude Mater. Infant.

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Resumo Objetivos: identificar as evidências científicas sobre tuberculose excessivamente resistente e multidroga resistente em pacientes pediátricos. Métodos: trata-se de uma revisão de escopo da literatura, tendo como questão norteadora: “Quais as evidências científicas sobre tuberculose multidroga-resistente (TB-MDR) e tuberculose extensivamente resistente em pacientes pediátricos?” A pesquisa usou os descritores: “tuberculose extensivamente resistente a medicamentos” OR “tuberculose resistente a múltiplos medicamentos” AND “pediatria”. A pesquisa foi realizada de modo duplo-cego nas bases de dados Medical Literature Analysis and Retrieval System Online, Regional Office for the Western Pacific’s Institutional Repository for Information Sharing, Embase/Elsevier e International Clinical Trials Registry Platform, com um corte temporal de 2011 a 2021, sendo a amostra final sintetizada de 18 artigos, nos quais avaliou-se o conteúdo metodológico por meio do nível de evidência. Resultados: os resultados mostraram a escassez de pesquisas de alto nível de evidência relacionadas à TB-MDR em crianças, ausência de posologia adequada das drogas de segunda linha para o público pediátrico e a importância do teste de sensibilidade a drogas para o tratamento dos casos. Conclusões: identificou-se que os obstáculos do tratamento TB-MDR se concentraram na ausência de protocolos detalhados, de dosagens medicamentosas seguras e com menor efeito colateral, e, principalmente, nos determinantes sociais do processo saúde e doença que envolvem a TB-MDR.

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“…Thus, although childhood TB is frequent, it may be underreported due to difficulties in diagnosis, as the clinical picture and radiological tests cannot be specific for the presence of the bacillus in this group. In addition, children up to 10 years of age have difficulties in expectorating their sputum, compromising the results of sputum smear microscopy and making early screening for the disease difficult (4) .…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal pattern and factors related to childhood tuberculosis

Sousa

Lourenço

Mendes

et al. 2022

Rev. Gaúcha Enferm.

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Aim: To identify the spatiotemporal pattern of childhood tuberculosis and the sociodemographic factors related to it. Method: This is an ecological study, which used the municipalities of the state of Ceará as units of analysis. The Notifiable Diseases Information System was used as a data source from January 2001 to December 2017. It was conducted a descriptive analysis of the characteristics of the cases, the temporal and spatial pattern of the incidence of the disease and regression with sociodemographic indicators. Results: An average incidence of 3.48 cases/100 thousand inhabitants was identified, with a reduction of 5.7% during the period 2003-2017 (p<0.001). The following were related to childhood tuberculosis: proportion of the population in households with piped water (β=0.05), proportion of the population in households with density >2 (β=0.09) and number of female heads of household with children under 15 years of age (β=0.0003). Conclusion: Indicators of housing conditions and vulnerability were related to childhood tuberculosis.

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Management and outcomes of severe childhood tuberculosis in the pediatric intensive care setting: can we identify best practices?

Cited by 5 publications

References 19 publications

Obstacles in combating multidrug resistant tuberculosis in pediatric patients: a scope review

Obstacles in combating multidrug resistant tuberculosis in pediatric patients: a scope review

Obstáculos no combate à tuberculose multidroga resistente em pacientes pediátricos: uma revisão de escopo

Spatiotemporal pattern and factors related to childhood tuberculosis

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